Yutopar
Yutopar Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Yutopar is a brand name. Its generic name is Ritodrine.
Yutopar Introduction
Yutopar is a synthetic beta-adrenergic agonist approved for preterm labor management. It is the first and only tocolytic primarily used to delay delivery in women with preterm labor.
Uses of Yutopar
Yutopar is primarily used to delay delivery in pregnant women with preterm labor, when delivery is judged to be inappropriate or inappropriately close.
Mechanism of Action
Yutopar acts as a partial agonist on β2-adrenoceptors to relax the uterine smooth muscle, which inhibits and delays preterm labor. In addition, it has direct vasodilator, indirect sympathomimetic, negative inotropic, and chronotropic effects.
How Long Does it Take to Work?
Yutopar takes 20-30 minutes to take effect if administered orally, with peak action occurring about one hour after administration.
Absorption
Yutopar is rapidly absorbed from the gastrointestinal tract with an onset of action of 20-30 minutes following oral administration.
Route of Elimination
Yutopar is metabolized in the liver and excreted by the kidneys in the form of metabolites.
Dosage
Yutopar is available as a tablet, an oral solution, and an intravenous solution. The recommended dosage for tablets is 10-30 mg orally every 6 hours. The recommended dosage for oral solution is 1-15 mg/5ml orally every 6 hours. The recommended dosage for intravenous solution is 500-1000 μg/ml intravenously every 6 hours.
Administration
Yutopar should be administered orally or intravenously every 6 hours. It is recommended to administer the drug with food and fluids to reduce the risk of gastrointestinal irritation and ulceration.
Side Effects
Common side effects of Yutopar are nausea, vomiting, headache, flushing, palpitations, chest pain, tachycardia, hypersensitivity reactions, thrombophlebitis, and hypotension.
Toxicity
The most common adverse effect associated with Yutopar is tachycardia. Side effects such as headache, nausea, vomiting, hypertension, hypotension, bradycardia, and pulmonary edema may occur with overdosage.
Precautions
Yutopar is not recommended for patients with a history of cardiovascular, liver, or kidney disease.
Patients taking Yutopar should be monitored closely for adverse effects and should report any symptoms immediately to their healthcare provider.
Interaction
Yutopar has potential interactions with other medications including beta-blockers, ACE inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), and certain antibiotics. It is highly recommended to check with a healthcare provider before taking any other medications while taking Yutopar.
Disease Interaction
Yutopar may cause worsening of heart and respiratory failure, arrhythmias, and physical and mental exhaustion in patients with pre-existing disease.
Drug Interaction
Yutopar may interact with other drugs, including beta-blockers, ACE inhibitors, NSAIDs, and certain antibiotics. It is important to consult with a healthcare provider before taking any other medications while taking Yutopar.
Food Interactions
Yutopar should be taken with food and fluids to reduce the risk of gastrointestinal irritation and ulceration.
Pregnancy Use
Yutopar is only recommended for use during pregnancy on the advice of a healthcare provider. Pregnant women should not take Yutopar unless it is prescribed by their doctor.
Lactation Use
Yutopar accumulates in breastmilk and is contraindicated in lactating women.
Acute Overdose
Acute overdose of Yutopar may result in nausea, vomiting, hypertension, hypotension, bradycardia, pulmonary edema, and death.
Contraindication
Yutopar is contraindicated in patients with uncontrolled or severe hypertension, asthma, cardiac failure, history of cardiac arrhythmias, CKD, severe renal impairment, and hypersensitivity to Yutopar.
Direction of Use
Yutopar should be taken with food and fluids to reduce the risk of gastrointestinal irritation and ulceration. It should be taken every 6 hours at the recommended dosage prescribed by the physician.
Storage Condition
Yutopar tablets should be stored at room temperature, away from heat, moisture, and direct sunlight.
Volume of Distribution
Yutopar has a volume of distribution of 4.5-6.5 liters/kg.
Half Life
The elimination half life of Yutopar is 1-4 hours.
Clearance
The clearance of Yutopar is 1.5-4.5 liters/hour/kg.
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