Xtraderm
Xtraderm Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Xtraderm is a brand name. Its generic name is Betamethasone + Clotrimazole + Gentamicin.
Introduction
Xtraderm is a combination of three steroidal anti-inflammatory drugs and a topical antifungal agent, specifically developed as an ointment for treating skin infections. Betamethasone is a corticosteroid, Clotrimazole is an antifungal agent and Gentamicin is an antibiotic. This medication is used to treat bacterial skin infections such as bacterial folliculitis, impetigo, and secondary infections due to dermatitis.
Uses
Xtraderm is used to treat bacterial skin infections such as bacterial folliculitis, impetigo, and secondary infections due to dermatitis. This medication is usually applied twice daily, leaving at least 8 hours between applications.
Mechanism of Action
Betamethasone is a corticosteroid. It reduces inflammation by suppressing the migration of leukocytes and reversing increased capillary permeability. Clotrimazole is an antifungal agent and works by inhibiting the growth of fungi. Gentamicin is an antibiotic and works by interfering with the production of essential proteins needed by the bacteria for survival.
How Long Does it Take to Work?
Xtraderm usually starts to work in a few days, but it may take up to two weeks for the full effect to be noticed.
Absorption
Xtraderm is quickly and completely absorbed when applied topically to the affected area of the skin. The combination is then broken down into its individual components (clotrimazole, gentamicin, and betamethasone) before being absorbed.
Route of Elimination
Xtraderm is eliminated through the renal system.
Dosage
Xtraderm is available as an ointment or cream, usually in concentrations of 0.05% betamethasone, 1% clotrimazole, and 0.1% gentamicin. The ointment or cream should be applied to the affected area of the skin twice daily, leaving at least 8 hours between applications. It should only be applied to intact skin, and not on broken or damaged skin.
Administration
Xtraderm should be applied to the affected area of the skin twice daily, leaving at least 8 hours between applications. It should only be applied to intact skin, and not on broken or damaged skin. Make sure to thoroughly wash your hands and the affected area before applying the medication.
Side Effects
Common side effects of Xtraderm may include: itching, burning, or stinging at the application site; dry or cracked skin; skin discoloration; or rash. Rarely, the ointment or cream may cause an allergic reaction. If you experience a severe reaction, stop using Xtraderm immediately and seek medical advice.
Toxicity
Xtraderm is generally well-tolerated, although long-term use or use of higher concentrations may cause irritation, sensitization, or local infection. Prolonged or over-use of Xtraderm can also result in systemic absorption of the drug, increasing the risk of toxicity.
Precautions
Before using Xtraderm, tell your healthcare provider if you are taking any other medications. Additionally, tell your healthcare provider if you are pregnant or breastfeeding or if you have a weakened immune system. Also, make sure to follow the recommended dosage and application instructions carefully.
Interactions
Xtraderm may interact with certain drugs, such as other topical medications, antifungal medications, anticoagulants, or immunosuppressants. Be sure to tell your healthcare provider about all the medications you are taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements.
Disease Interaction
Xtraderm may interact with certain diseases, such as skin infections caused by bacteria, viruses, or fungi; dermatitis; eczema; or psoriasis. Make sure to tell your healthcare provider if you have any existing medical condition that may be affected by Xtraderm.
Drug Interactions
Xtraderm may interact with certain drugs, such as other topical medications, antifungal medications, anticoagulants, or immunosuppressants. Be sure to tell your healthcare provider about all the medications you are taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements.
Food Interactions
Xtraderm may interact with certain foods, such as dairy, alcohol, or spicy foods. It is important to check with your healthcare provider about any specific dietary or food restrictions before taking Xtraderm.
Pregnancy Use
Xtraderm is classified as a pregnancy Category C drug, which means that it has not been adequately studied for use during pregnancy. Therefore, Xtraderm should be used during pregnancy only if clearly needed and recommended by your healthcare provider.
Lactation Use
It is not known whether Xtraderm is excreted in human milk. Therefore, use of this medication during lactation is not recommended without medical advice.
Acute Overdose
There have not been any reports of acute overdose with Xtraderm. However, if overdose is suspected, seek medical attention immediately.
Contraindication
Xtraderm should not be used in patients with a history of hypersensitivity to any of the ingredients, as well as in patients with a weakened immune system, severe hepatic or renal impairment, or active tuberculosis. Consulting your healthcare provider can help you determine if Xtraderm is right for you.
Use Direction
Before use, make sure to thoroughly wash your hands and the affected area. Xtraderm should be applied to the affected area of the skin twice daily, leaving at least 8 hours between applications. Do not use this medication on broken, infected, or inflamed skin.
Storage Condition
Xtraderm should be stored at room temperature (15-30°C). Avoid exposing to extreme temperatures, direct sunlight, and humidity.
Volume of Distribution
This term refers to the amount of drug that reaches the systemic circulation following intravenous administration of the drug. The volume of distribution for Xtraderm is not known.
Half Life
The half-life of Xtraderm is not known.
Clearance
This term refers to the rate at which a drug is cleared from the body. The clearance of Xtraderm is not known.
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