Wontra

Wontra Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Wontra is a brand name. Its generic name is Tramadol.

Wontra

Wontra, (generic name: tramadol hydrochloride), is an opioid medication used to treat moderate to severe pain. It is an opioid agonist, meaning it stimulates opioid receptors in the brain, activating them and producing an analgesic effect. Wontra also works on serotonin and norepinephrine receptors, further enhancing its pain-relieving effect. Wontra is available in both immediate-release and extended-release forms.

Uses For Wontra

Wontra is prescribed to treat moderate to severe pain in both adults and children, as well as in adolescents between the ages of 12 and 18. It is also used off-label to treat pain associated with fibromyalgia, painful neuropathy, and headaches. Because of its opiate-like effects, Wontra is sometimes prescribed for the treatment of opioid dependence.

Mechanism Of Action

Wontra works by binding to opioid receptors in the brain and spinal cord, and increasing the activity of serotonin (which helps reduce the pain signals sent to the brain). Wontra also binds to the norepinephrine receptor, which further enhances its pain-relieving effect. The combination of its opioid and monoamine agonism is responsible for its analgesic effects.

How Long Does It Take To Work?

Wontra typically begins to work within 30 minutes to an hour of being taken. The duration of its effects usually last about 4-6 hours. With extended-release tablets, effects may last up to 12 hours.

Absorption

Wontra is rapidly and completely absorbed from the gut into the blood stream, with peak blood levels occurring one to two hours after ingestion. It is highly soluble in water, and rapidly distributed throughout the body.

Route Of Elimination

Wontra is broken down and eliminated by the liver and kidneys. About 90% of an administered dose is eliminated via the kidneys, and 10% via the bile. It typically takes 4-6 hours for tramadol to be eliminated from the body.

Dosage

Dosage of Wontra depends on the task of its use. A starting dose of the medication is usually 25-50mg every four to six hours, for which the maximum dose should not exceed 400mg in a day. For treating breakthrough pain, the dose can be increased to 150-200mg per day. Extended release tablets should be taken once a day, with the maximum dose not exceeding 300mg in a day.

Administration

Wontra can be taken orally or administered through an IV. Oral tablets and capsules should be taken with food to reduce the risk of gastrointestinal adverse effects. Oral liquid preparations should be administered with a specifically designed measuring device, and not with a regular teaspoon.

Side Effect

Common side effects of Wontra include nausea, vomiting, drowsiness, dizziness, headache, constipation, and dry mouth. Other side effects may include difficulty urinating, loss of appetite, sweating, confusion, and itchy skin. In some cases, more serious side effects such as respiratory depression, hallucinations, and seizures can occur.

Toxicity

Wontra is generally considered safe and well-tolerated when used as prescribed. But at higher doses, especially when taken with other medications that also act on the central nervous system, it can be toxic, and may lead to serious respiratory depression, comas, and even death.

Precautions

Wontra should be taken with caution, especially in individuals with a history of alcohol abuse or addiction, mental illness, thyroid problems, kidney or liver disease, or a history of convulsions, seizures, or head injury. Wontra should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives or other narcotic medications.

Interaction

Wontra may interact with certain medications such as anticoagulants, antidepressants, monoamine oxidase inhibitors, drugs for high blood pressure, drugs for mental illness, antihistamines, muscle relaxants, and opioids, increasing the risk of toxicity and other side effects.

Disease Interaction

Wontra may interact with certain diseases such as seizure disorders, head injury, liver or kidney disease, and respiratory depression, increasing the risk of toxicity and other side effects. Patients with any of these diseases should talk to their doctor before starting tramadol therapy.

Drug Interaction

Wontra can interact with several drugs, including alcohol, Monoamine Oxidase inhibitors (MAOIs), anticoagulants, sedatives, muscle relaxants, and opioids. These interactions can increase the risk of toxicity and other side effects. Patients should check with their doctor before starting or stopping any medication while taking tramadol.

Food Interactions

Wontra should be taken with food to reduce the risk of gastrointestinal adverse effects. Grapefruit juice should be avoided when taking tramadol, as it can increase the absorption of the drug and potentially increase its toxicity. Certain foods such as aged cheese, red wine, and pickled or smoked meats can also interact with tramadol.

Pregnancy Use

Wontra is not recommended for use in pregnant women. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are pregnant or breastfeeding should talk to their doctor before taking tramadol.

Lactation Use

Wontra should not be used during breastfeeding. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are breastfeeding should talk to their doctor before taking tramadol.

Acute Overdose

Overdose of tramadol can lead to respiratory depression, comas, and even death. Symptoms of an overdose can include pinpoint pupils, confusion, slowed breathing, seizure, and loss of consciousness. Treatment for an overdose may include administration of naloxone, an opioid antagonist, or other supportive care measures.

Contraindication

Wontra is contraindicated in patients who are hypersensitive to it or any of its components. It is also contraindicated in patients who are taking MAO inhibitors, strong CYP3A4 inhibitors, and certain opioid drugs such as meperidine. Additionally, tramadol should not be taken in combination with alcohol or other CNS depressants.

Use Direction

Wontra should be taken as directed by a physician. It should be taken with food to reduce the risk of gastrointestinal adverse effects. The dosage of tramadol should be adjusted based on patient’s response and symptoms. It should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives, or other narcotic medications.

Storage Condition

Wontra should be stored at room temperature in a light-resistant, child-resistant container. It should be kept away from heat and moisture, and out of the reach of children and pets.

Volume Of Distribution

Wontra has a volume of distribution of 0.4L/kg, meaning that 0.4L of the drug is distributed throughout the body for every kg of the patient’s weight.

Half Life

Wontra has a half-life of 4-6 hours, meaning it takes 4-6 hours for half of the drug to be eliminated from the body.

Clearance

Wontra has a clearance rate of 0.11L/kg/hour, meaning that 0.11L of the drug is eliminated from the body every hour for every kg of the patient’s weight.

Here you find in details version of Wontra

Some Frequently Asked Questions About Wontra

What is Wontra?

Wontra is an opioid-type pain reliever (analgesic) used to treat moderate to moderately severe pain. It is available in both immediate-release and extended-release formulations.

What is the generic name of Wontra?

Wontra's generic name is Ultram.

What is the mechanism of action of Wontra?

Wontra works by binding to and activating opioid receptors located in the brain, which helps reduce the perception of pain.

Is Wontra a controlled substance?

Yes, Wontra is classified as a Schedule IV controlled substance in the United States, suggesting that it has a low potential for abuse.

How fast does Wontra work?

Wontra works within 30 minutes of taking a dose and its effects can last up to 4-6 hours.

How should Wontra be taken?

Wontra should be taken exactly as prescribed by the doctor. It can be taken with or without food but should not be crushed, split, or chewed before taking.

What are the side effects of Wontra?

The most common side effects of Wontra include nausea, vomiting, constipation, headache, dizziness, drowsiness, and dry mouth.

Can I take acetaminophen and Wontra together?

Yes, acetaminophen and Wontra can be taken together as long as the total daily dose of acetaminophen does not exceed 4,000 milligrams.

What are the signs of an overdose of Wontra?

Signs of an overdose of Wontra include extreme drowsiness, confusion, shallow breathing, faster heart rate, nausea, vomiting, and fainting.

Can Wontra be used for back pain?

Yes, Wontra is often prescribed for the treatment of back pain.

Is Wontra addictive?

Yes, Wontra can be addictive when taken in large amounts or for long periods of time.

What should I do if I forget to take a dose of Wontra?

If you forget to take a dose of Wontra, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can Wontra be taken with alcohol?

No, Wontra should not be taken with alcohol as it can increase the risk of side effects such as extreme drowsiness and respiratory depression.

Should I avoid caffeine while taking Wontra?

Yes, as caffeine can increase the risk of nervousness, difficulty sleeping, and fast or irregular heartbeat.

Is Wontra safe for long-term use?

Wontra is generally considered safe for short-term use, but its effects can diminish with long-term use, increasing the risk of addiction and overdose.

Can Wontra be taken during pregnancy?

Wontra should not be taken during pregnancy as it can cause harm to the fetus.

Can I take Wontra if I have a history of drug abuse?

No, Wontra should not be taken if you have a history of drug abuse as it can be addictive and could cause relapse.

Will Wontra show up on a drug test?

Yes, Wontra may show up on a drug test, though the results may vary depending on the type of test.

Can I take Wontra if I have liver or kidney disease?

Wontra should be used with caution in patients with a history of liver or kidney disease, as they may be more sensitive to its effects.

Can I take Wontra with anti-anxiety medications?

No, Wontra should not be taken with anti-anxiety medications, as it may increase the risk of adverse reactions.

What should I do if I experience any side effects from Wontra?

If you experience any side effects from Wontra, contact your doctor as soon as possible.

What other pain relievers can be taken with Wontra?

Wontra can be taken with other non-opioid pain relievers such as ibuprofen and acetaminophen.

What is the maximum daily dose of Wontra?

The maximum daily dose of Wontra is 400 milligrams per day for adults.

Does Wontra cause constipation?

Yes, constipation is a common side effect of Wontra.

Can I take Wontra and Wontra Plus together?

No, Wontra and Wontra Plus should not be taken together as it may increase the risk of adverse reactions.

Can Wontra be taken for headaches?

Yes, Wontra is often prescribed for the treatment of headaches.

Is Wontra ever prescribed for arthritis?

Yes, Wontra is sometimes prescribed for the treatment of arthritis.

Does Wontra interact with other medications?

Yes, Wontra may interact with other medications, so it is important to discuss any other medications you are taking with your doctor before taking Wontra.

Can Wontra be taken for menstrual cramps?

Yes, Wontra can be prescribed for the treatment of menstrual cramps.

Can Wontra be crushed for easier swallowing?

No, Wontra should not be crushed before taking because the medication may be released too quickly, leading to increased risk of side effects.

What other conditions can Wontra be used to treat?

Wontra may be prescribed to treat chronic pain, fibromyalgia, and neuropathic pain, among other conditions.

Can I take Wontra while breastfeeding?

No, Wontra should not be taken while breastfeeding as it can be passed through breast milk and could cause harm to a nursing baby.

Can Wontra be taken with anti-depressants?

Yes, Wontra can be taken with certain types of anti-depressants, but should not be taken with monoamine oxidase inhibitors (MAOIs).

Can Wontra be taken with vitamins or supplements?

Yes, Wontra can be taken with certain vitamins and supplements, but it is important to discuss any medications you are taking with your doctor before taking Wontra.

Can Wontra be taken with antihistamines?

Yes, Wontra can be taken with certain antihistamines, but it is important to check with your doctor before taking any medication.

Can I take Wontra with other pain relievers?

No, Wontra should not be taken with other opioid-type pain relievers as this increases the risk of adverse reactions and overdose.

Is Wontra metabolized by the liver?

Yes, Wontra is metabolized in the liver and it is important to discuss any history of liver or kidney disease with your doctor before taking Wontra.

How long will Wontra stay in my system?

Wontra can stay in the system for up to 24 hours after the last dose.

What should I do if I miss a dose of Wontra?

If you miss a dose of Wontra, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can I take Wontra while taking other medications?

Yes, Wontra can be taken with certain medications, but it is important to discuss any medications you are taking with your doctor before taking Wontra.

Does Wontra affect blood pressure?

Yes, Wontra may cause an increase in blood pressure, so it is important to talk to your doctor if you have any concerns.

What is Wontra HCL?

Wontra HCL (hydrochloride) is a prescription medication used to treat pain. It is available in both immediate-release and extended-release formulations.

What are the withdrawal symptoms of Wontra?

The withdrawal symptoms of Wontra may include insomnia, agitation, anxiety, nausea, vomiting, sweating, and runny nose.

Can Wontra cause hallucinations?

Yes, Wontra can cause hallucinations, especially at higher doses.

Is Wontra the same as Vicodin?

No, Wontra and Vicodin are different medications. Wontra is an opioid-type pain reliever while Vicodin is a combination of an opioid and acetaminophen.

Can Wontra be taken with other medications for pain?

Yes, Wontra can be taken with other medications for pain, but it is important to discuss any medications you are taking with your doctor before taking Wontra.