Ureativ
Ureativ Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ureativ is a brand name. Its generic name is Hydroxyurea.
Ureativ
Ureativ is a prescription medication used to treat certain types of cancer, such as chronic myelogenous leukemia (CML) and certain types of ovarian, head and neck, and skin cancer. It works by slowing down the growth of cancer cells and is also sometimes used to reduce the symptoms of sickle cell anemia.
Uses of Ureativ
Ureativ is used to treat certain types of cancer, including CML, ovarian cancer, head and neck cancer, and certain types of skin cancer. It can also be used to reduce the number of painful episodes of sickle cell anemia.
Mechanism of Action
Ureativ works by slowing down the growth of new cancer cells. It does this by inhibiting the enzyme ribonucleotide reductase, which is involved in the production of DNA. As a result, the growth of cancer cells is slowed down.
How Long Does It Take to Work?
The effects of hydroxyurea can be seen within 1-6 weeks. However, for some people, the benefits may not be seen until after 6-8 weeks of taking the medicine.
Absorption
Ureativ is well absorbed from the gastrointestinal tract. It has an absolute bioavailability of 97%.
Route of Elimination
Ureativ is metabolized in the liver and is primarily eliminated in the urine as unchanged drug and metabolites.
Dosage
The recommended dose of hydroxyurea depends on the type and severity of the medical condition being treated. Common doses range from 500mg to 2000mg per day.
Administration
Ureativ should be taken by mouth. It is usually taken with or without food. It is important to take it at the same time each day and to take it exactly as prescribed by your doctor.
Side Effects
Common side effects of hydroxyurea include nausea, vomiting, diarrhea, loss of appetite, and mouth sores. Other serious side effects include skin irritation, low white blood cell counts, and anemia.
Toxicity
Ureativ is generally well tolerated. However, it can become toxic when taken in high dosages for long periods of time. Toxicity symptoms include vomiting, diarrhea, decreased appetite, and mouth sores.
Precautions
Ureativ should be used with caution in people with anemia, kidney or liver disease, bone marrow suppression, and those taking certain medications such as anticoagulants.
Interactions
Ureativ may interact with certain medications such as anticoagulants, immune suppressants, and chemotherapy drugs. Always tell your doctor and pharmacist about any medications you are taking.
Disease Interactions
Ureativ should be used with caution in people with anemia, kidney or liver disease, or bone marrow suppression. It should also not be used in people who are pregnant or breastfeeding.
Drug Interactions
Ureativ may interact with certain medications, including anticoagulants, immune suppressants, and chemotherapy drugs. Always tell your doctor and pharmacist about any medications you are taking before starting hydroxyurea.
Food Interactions
Ureativ may interact with certain foods, such as dairy products and alcohol. It is important to discuss any potential food interactions with your doctor or pharmacist before taking hydroxyurea.
Pregnancy and Lactation Use
Ureativ should not be used during pregnancy or while breastfeeding. It can be harmful to a developing fetus or nursing baby. Talk to your doctor about the potential risks before taking this medication.
Acute Overdose
If an overdose occurs, seek immediate medical attention. Symptoms of an overdose may include nausea, vomiting, and stomach pain.
Contraindications
Ureativ should not be used in people who are pregnant or breastfeeding, or those who are hypersensitive to the drug.
Use Direction
Ureativ is usually taken by mouth with or without food at the same time every day. Follow the instructions given by your doctor or pharmacist. Do not take more or less than the recommended dose.
Storage Condition
Ureativ should be stored at room temperature in a dry, dark place away from heat and moisture. Keep out of reach of children.
Volume of Distribution
The volume of distribution of hydroxyurea ranges from 6 to 9 liters.
Half Life
The half-life of hydroxyurea ranges from 1 to 2 hours.
Clearance
The clearance of hydroxyurea is approximately 15 liters/hour.
Here you find in details version of Ureativ
Some Frequently Asked Questions About Ureativ
What is hydroxyurea?
Ureativ is a prescription medication used to treat certain types of cancer, sickle cell anemia, and polycythemia vera. It is a type of chemotherapy that works by slowing down the rate at which the cancer cells grow and divide.
What is hydroxyurea used for?
Ureativ is used to treat certain types of cancer, sickle cell anemia, and polycythemia vera. It is a type of chemotherapy that works by slowing down the rate at which the cancer cells grow and divide.
How does hydroxyurea work?
Ureativ works by blocking the production of certain proteins and enzymes that are needed for the growth and division of cells. This slows down the growth and division of cancer cells, which stops them from multiplying and spreading.
How is hydroxyurea taken?
Ureativ is taken as a capsule or liquid, usually once or twice a day. Follow your doctor's instructions carefully. Take it at the same time each day. Do not take a double dose. Take it until your doctor tells you to stop.
What are the side effects of hydroxyurea?
Common side effects of hydroxyurea include nausea, vomiting, diarrhea, loss of appetite, fatigue, and skin rash. Other side effects include mouth sores, hair loss, and changes in blood counts. Talk to your doctor about the side effects of hydroxyurea.
What should I do if I miss a dose of hydroxyurea?
If you miss a dose of hydroxyurea, take it as soon as you remember. If it is time for your next dose, skip the missed dose and take the next dose on the regularly scheduled time. Do not take a double dose.
How long does hydroxyurea take to work?
It may take several weeks for hydroxyurea to take effect. The response to the medication and how long it takes to work will vary depending on the condition being treated and how the individual responds to the medication. Talk to your doctor about questions about the time it takes for hydroxyurea to work.
Are there any foods or drinks I should limit or avoid while taking hydroxyurea?
You should avoid consuming large amounts of grapefruit while on hydroxyurea, as it may increase the levels of hydroxyurea in your body and cause side effects. Talk to your doctor about any foods or drinks you should limit or avoid while taking hydroxyurea.
Is there a generic version of hydroxyurea?
Yes, there is a generic version of hydroxyurea available. Talk to your doctor or pharmacist about generic or brand name hydroxyurea.
What should I do if I experience an allergic reaction to hydroxyurea?
If you experience an allergic reaction to hydroxyurea, stop taking the medication and contact your doctor or healthcare provider right away. Symptoms of an allergic reaction may include difficulty breathing, chest tightness, rash, itching, swelling, and hives.
Can I drink alcohol while taking hydroxyurea?
You should not drink alcohol while taking hydroxyurea. Alcohol can increase the side effects of hydroxyurea. Talk to your doctor about any questions or concerns regarding drinking alcohol and taking hydroxyurea.
What is the most important information I should know about hydroxyurea?
The most important information you should know about hydroxyurea is that it can cause serious side effects. It is important to tell your doctor if you are pregnant or breastfeeding or if you have any pre-existing medical conditions.
What is the usual dosage of hydroxyurea?
The usual dosage of hydroxyurea is one capsule or 10 mL per day orally, or as instructed by your doctor. The dosage may vary based on the condition being treated, your medical history, weight, and other factors. Follow your doctor’s instructions for taking hydroxyurea.
What should I tell my healthcare provider before taking hydroxyurea?
Before taking hydroxyurea, be sure to tell your healthcare provider if you are pregnant or breastfeeding, or if you have any pre-existing medical conditions. Also, let them know about any other medications or supplements you are taking, as they may interact with hydroxyurea.
What are the long-term effects of hydroxyurea use?
Long-term use of hydroxyurea may cause serious side effects, including bone marrow suppression and decreases in blood counts. It can also cause birth defects if taken during pregnancy. Talk to your healthcare provider about the long-term effects of hydroxyurea use.
How often should I get blood tests while taking hydroxyurea?
It is important to get regular blood tests while taking hydroxyurea, as it can cause decreases in your blood counts. Talk to your healthcare provider about how often you should get blood tests, as this may vary depending on a variety of factors.
Can hydroxyurea interact with other medications?
Yes, hydroxyurea can interact with other medications. Be sure to tell your healthcare provider about all of the medications and supplements you are taking, as some may interact with hydroxyurea.
What should I do if I develop an infection while taking hydroxyurea?
If you develop an infection while taking hydroxyurea, contact your healthcare provider right away. Ureativ can suppress the immune system and can make infections more difficult to fight. Your healthcare provider may prescribe an antibiotic to help treat the infection.
How do I store hydroxyurea?
Ureativ should be stored at room temperature, away from moisture and heat. Keep it out of the reach of children and pets. Do not store the liquid form of hydroxyurea in the refrigerator.
What should I do if I accidentally take an overdose of hydroxyurea?
If you accidentally take an overdose of hydroxyurea, contact your healthcare provider right away or call 911. Overdosing on hydroxyurea can cause serious side effects.
Can I get a flu shot or other vaccines while taking hydroxyurea?
You should talk to your healthcare provider before getting any vaccines while taking hydroxyurea. Ureativ can suppress the immune system and can make vaccines less effective.
Should I avoid any activities while taking hydroxyurea?
You should avoid activities that could put you at an increased risk of infection while taking hydroxyurea. Ureativ can suppress the immune system and can make fighting off infections more difficult. Talk to your doctor about activities to avoid while taking hydroxyurea.
Does hydroxyurea cause any skin changes?
Yes, hydroxyurea can cause skin changes. You should tell your doctor if you have any changes in skin color or texture while taking hydroxyurea. Other skin changes can include rashes, itching, swelling, and other allergic reactions.
Does hydroxyurea affect fertility?
Yes, hydroxyurea can affect fertility. Men taking hydroxyurea may have a decreased sperm count. Women taking hydroxyurea may have a decreased egg count. Talk to your healthcare provider about any questions you have regarding fertility while taking hydroxyurea.
Can hydroxyurea cause hair loss?
Yes, hydroxyurea can cause hair loss. This side effect is usually temporary and may improve with continued use of the medication. Talk to your doctor if your hair loss does not improve or if you have any questions or concerns about this side effect.
Can hydroxyurea cause nausea and vomiting?
Yes, hydroxyurea can cause nausea and vomiting. These side effects may improve with continued use of the medication. Talk to your doctor about ways to reduce nausea and vomiting while taking hydroxyurea.
Is hydroxyurea safe for long-term use?
Ureativ is generally safe for long-term use but it can cause serious side effects. Talk to your healthcare provider about any questions or concerns you have regarding the safety of long-term use of hydroxyurea.
What should I avoid while taking hydroxyurea?
You should avoid excessive exposure to the sun while taking hydroxyurea as it can increase the risk of skin changes. You should also avoid alcohol and large amounts of grapefruit juice while taking hydroxyurea. Talk to your healthcare provider about any activities or foods to avoid while taking hydroxyurea.
Is there anything else I should know about hydroxyurea?
You should also avoid smoking while taking hydroxyurea. Smoking can increase the side effects of the medication. Talk to your healthcare provider about any other questions or concerns you have regarding hydroxyurea.