tysabri
tysabri Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? tysabri is a brand name. Its generic name is Natalizumab.
tysabri Introduction
tysabri (also known as Tysabri) is an injectable prescription medication used to treat multiple sclerosis (MS) and Crohn's disease. It is administered via subcutaneous or intravenous injections. It is often used to treat people with relapsing forms of multiple sclerosis.
Uses for tysabri
tysabri is used to slow down the progression of MS and Crohn's disease and can even sometimes reduce the frequency of relapses with MS. It can reduce the number of inflammation-causing cells known as lymphocytes from entering the central nervous system and causing damage. In individuals with Crohn's disease, it helps to reduce inflammation caused by lymphocytes and improve symptoms.
Mechanism of Action
tysabri works by blocking the interaction of the protein α4-integrin with its receptor on other cells, thus preventing lymphocytes from entering the central nervous system or causing inflammation in the gut and thus reducing symptoms of MS and Crohn's disease.
How long does it take to work?
It can take up to six months for tysabri to reach its full potential effectiveness. It is important to keep up with the regular dosing schedule to ensure optimal benefits.
Absorption
tysabri is rapidly absorbed after subcutaneous injection. Peak concentrations are reached within an hour of injection and can achieve a maximal concentration within 5 hours.
Route of Elimination
tysabri is eliminated primarily through metabolism and renal excretion.
Dosage
tysabri is usually administered as a 0.5 ml dosage once every 4 weeks. The dosage may be different for each patient, so it is important to always follow the instructions from your healthcare provider. Instructions may also vary depending on which type of injection you are given.
Administration
tysabri is injected either subcutaneously or intravenously, depending on your doctor's recommendation. The injection should be administered by a healthcare provider.
Side Effects
The most common side effects of tysabri include headache, nausea, abdominal pain, and fatigue. Other serious side effects may include an increased risk of infection, weakness, depression, dizziness, and vision changes. Talk to your doctor about any side effects that are concerning.
Toxicity
There is a risk of serious toxicity and adverse reactions with the use of tysabri. The most serious is a condition known as progressive multifocal leukoencephalopathy (PML). While the risk of serious toxicity is low, it is important to talk to your doctor about any signs or symptoms of PML.
Precautions
tysabri should not be used if you are pregnant or breastfeeding, or if you have an active infection. Make sure to tell your doctor about any medications you are taking or if you have had any recent vaccinations before starting treatment with tysabri.
Interaction
tysabri may interact with certain medications, including immunosuppressive drugs and medications used to treat infections. Make sure to tell your doctor about any medications you are taking before starting treatment.
Disease Interaction
tysabri may interact with certain diseases, including active tuberculosis, HIV, and hepatitis B or C. Talk to your doctor about any diseases or conditions you have before starting treatment.
Drug Interaction
tysabri may interact with certain medications, including immunosuppressants and medications used to treat infections. Make sure to tell your doctor about any medications you are taking before starting treatment.
Food Interactions
tysabri does not interact with food, but speak to your doctor if you are having difficulty eating or drinking while taking tysabri.
Pregnancy Use
tysabri should not be used in pregnant women as there is a risk of harm to the baby. Talk to your doctor about the potential risks and benefits before using tysabri.
Lactation Use
It is not known if tysabri is passed through breastmilk. Talk to your doctor about the potential benefits and risks before taking tysabri.
Acute Overdose
There have been no reports of an acute overdose on tysabri. The most common symptom of an overdose is nausea. If you or someone around you experiences nausea after taking an overdose, immediately call a poison control center or seek medical attention.
Contraindication
tysabri should not be used if you are pregnant or breastfeeding, or if you have an active infection. Talk to your doctor about any medications you are taking or any diseases or conditions you have before starting treatment with tysabri.
Use Direction
tysabri should be injected either subcutaneously or intravenously. Always follow the directions from your healthcare provider and refer to the patient information leaflet before administering.
Storage Condition
tysabri should be stored in a refrigerator at 2-8°C or at room temperature below 25°C. It should not be frozen.
Volume of Distribution
The volume of distribution of tysabri is not known.
Half Life
The estimated half-life of natalizumab is roughly 7-11 days.
Clearance
tysabri is eliminated primarily through metabolism and renal excretion. The clearance of natalizumab is approximately 1 L/day.
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