Tritab (ANTI-TUBERCULOSIS)
Tritab (ANTI-TUBERCULOSIS) Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tritab (ANTI-TUBERCULOSIS) is a brand name. Its generic name is Ethambutol + Isoniazid + Rifampicin.
Introduction
Ethambutol, Isoniazid, and Rifampicin is a combination medication used to treat tuberculosis. The three medications are bacteria-fighting agents that interfere with the growth of bacteria and kill them off. This medication is usually taken for at least 6 months to prevent the bacteria from growing again.Uses
Ethambutol, Isoniazid and Rifampicin are used to treat tuberculosis caused by Mycobacterium tuberculosis. It is usually used in combination with other medication.Mechanism of Action
Ethambutol, Isoniazid and Rifampicin work by interfering with the bacterial cell wall synthesis, thus preventing the bacteria from growing and reproducing. Ethambutol specifically prevents the bacteria from producing folic acid, while Isoniazid inhibits the biosynthesis of mycolic acids and Rifampicin increases the permeability of the cell wall, thus weakening the bacteria.How Long Does It Take To Work
It usually takes a few weeks to several months for the medications to take effect. The length of treatment and dosage may vary depending on the individual's response, as well as the type and severity of the infection.Absorption
Ethambutol, Isoniazid and Rifampicin are all well absorbed when taken orally.Route of Elimination
The drugs are eliminated primarily by the kidneys in the form of metabolites.Dosage and Administration
The dosage of Ethambutol, Isoniazid and Rifampicin will depend on the patient's response to the medication and the severity of the infection. It is best to follow the dosage and instructions provided by your doctor when taking this medication. The usual adult dose for Ethambutol is 800 mg per day, Isoniazid is 300 mg per day, and for Rifampicin is 600 mg per day.Side Effects
Common side effects of Ethambutol, Isoniazid and Rifampicin include nausea, vomiting, diarrhea, headache, weakness, dizziness, skin rash and changes in vision.Toxicity
Overdose of Ethambutol, Isoniazid and Rifampicin may lead to serious complications such as seizures, renal failure, liver failure, and death.Precautions
It is important to tell your doctor about any medical conditions that you may have or if you are pregnant/breastfeeding before taking this medication. If you experience any of the side effects listed above, stop taking this medication and contact your doctor immediately.Interaction
Ethambutol, Isoniazid and Rifampicin may interact with other medications, vitamins, or supplements you are taking, so it is important to tell your doctor about any other medications you are taking.Disease Interactions
Ethambutol, Isoniazid and Rifampicin may interact with diseases such as diabetes, liver/kidney disease, HIV, tuberculosis, and allergies.Drug Interactions
Ethambutol, Isoniazid and Rifampicin may interact with other drugs such as anti-seizure drugs, anticoagulants, antibiotics, anti-inflammatory drugs, anti-fungal drugs, and corticosteroids.Food Interactions
It is important to take Ethambutol, Isoniazid and Rifampicin with or after a meal to reduce the risk of nausea or vomiting. Do not take this medication with grapefruit juice as it may increase the risk of side effects.Pregnancy Use
Taking Ethambutol, Isoniazid and Rifampicin during pregnancy has not been studied and is not recommended.Lactation Use
It is not known if Ethambutol, Isoniazid and Rifampicin passes into breast milk, so it is not recommended to be taken by breastfeeding mothers.Acute Overdose
Symptoms of an acute overdose include seizures, loss of consciousness, vomiting, and coma. If an acute overdose happens, seek medical attention immediately.Contraindication
Ethambutol, Isoniazid and Rifampicin are contraindicated in patients with known hypersensitivity to any of its components.Use Direction
Take Ethambutol, Isoniazid and Rifampicin exactly as your doctor has prescribed and only for as long as your doctor has told you. Follow all the instructions on the prescription label. Do not change the dose or stop taking the medication unless your doctor has told you to do so.Storage Condition
Ethambutol, Isoniazid and Rifampicin should be stored at room temperature, away from direct sunlight or heat. Do not refrigerate or freeze the medication.Volume of Distribution
Ethambutol is distributed in a large volume due to its high solubility in lipids. Isoniazid is widely distributed throughout the body. Rifampicin is distributed in a small volume with significant protein binding.Half-Life
The half-life of Ethambutol is 10-15 hours, Isoniazid is 1-4 hours, and Rifampicin is 2-4 hours.Clearance
Ethambutol is cleared by the kidneys, Isoniazid is cleared by the kidneys and liver, and Rifampicin is cleared by the kidneys and liver.Here you find in details version of Tritab (ANTI-TUBERCULOSIS)