Treprostinil Tillomed
Treprostinil Tillomed Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Treprostinil Tillomed is a brand name. Its generic name is Treprostinil.
Treprostinil Tillomed
Treprostinil Tillomed, also known commercially as Orenitram is a type of prostacyclin analog, which is a drug that is used to treat pulmonary arterial hypertension in adults with World Health Organization group I pulmonary arterial hypertension. It works by improving the tolerance of oxygen, increasing blood supply, and widening the blood vessels, thus helping to keep blood pressure down.
Uses and Mechanism of Action
Treprostinil Tillomed is used to treat pulmonary arterial hypertension (PAH) in adult patients. It works by dilating the blood vessels, improving oxygen supply and tolerance, and reducing blood pressure. It is an effective long-term treatment that provides relief from symptoms such as shortness of breath, dizziness, and fatigue.
How Long Does it Take To Work?
Treprostinil Tillomed usually begins to have an effect within a few days after treatment starts. It is effective in reducing symptoms usually within one to two weeks. It may take several months to obtain a full benefit.
Absorption, Route of Elimination, and Dosage
Treprostinil Tillomed is absorbed rapidly from the gastrointestinal tract. It is eliminated primarily by the liver and kidney, with a minimum half-life of approximately 1 hour. Treprostinil Tillomed is available as an oral tablet in the dosage range of 1.25 to 34 mg twice per day. It is also available as an injectable solution for intravenous or subcutaneous use, with a recommended dosage of 5 to 30 ng/kg/minute.
Administration
Treprostinil Tillomed is typically taken twice a day, with equally spaced doses. It can be administered orally as a tablet or as an injectable solution, either intravenously or subcutaneously.
Side Effects, Toxicity, and Precautions
Treprostinil Tillomed is generally well-tolerated, however, common side effects associated with its use include headache, dizziness, nausea, vomiting, diarrhea, constipation, sweating, itching, rash, swelling in the hands and feet, and weight gain. Other potential side effects include chest pain, shortness of breath, muscle pain, palpitations, and abnormal heart rhythms. Treprostinil Tillomed is considered to be non-toxic, however, in rare cases it may cause severe reactions. It is important to carefully follow the dosage recommendations and to contact a health care provider if any signs of an adverse reaction occur.
Interaction
Treprostinil Tillomed may interact with other medications, so it is important to inform one's health care provider of any other medications being taken and to check with a pharmacist before taking any new medications. Treprostinil Tillomed may interact with other drugs known to prolong the QT interval, such as macrolide antibiotics, certain antibiotics, and antiarrhythmic agents.
Disease Interaction and Drug Interaction
In addition to potential interactions with other medications, Treprostinil Tillomed may interact with certain diseases or conditions such as advanced liver disease, low blood pressure, low potassium or magnesium levels, and heart rhythm disturbances. Patients with these conditions may need to be monitored more closely while taking Treprostinil Tillomed.
Food Interactions
Treprostinil Tillomed is not known to interact with food. However, it is always recommended to speak to a healthcare provider before taking any medication alongside meals or other food.
Pregnancy and Lactation Use
Treprostinil Tillomed is not recommended during pregnancy or lactation, as there is insufficient evidence to determine its safety. It is advised that pregnant women should discuss the risks and potential benefits with their doctor before taking Treprostinil Tillomed.
Acute Overdose
Acute overdose of Treprostinil Tillomed may result in nausea, vomiting, and hypotension. Supportive care should be given in the case of an overdose, and dialysis may be needed. Contact a poison control centre or a healthcare provider immediately if an overdose is suspected.
Contraindication
Treprostinil Tillomed is contraindicated in patients with known hypersensitivity to the drug. It should also not be used in patients who have known or suspected impaired liver function, or in patients with cardiac conditions, such as second- or third-degree atrioventricular block or ventricular tachycardia.
Use Direction
Treprostinil Tillomed should be taken exactly as prescribed by a physician. It should be taken twice daily as prescribed, with or without food. It is important that the dosage not be changed without consulting a healthcare provider.
Storage Condition
Treprostinil Tillomed should be stored at room temperature, away from light and moisture. It should not be stored in the bathroom or near a sink. Unused medication should be discarded appropriately in a trash can, not flushed down the toilet or poured down the sink.
Volume of Distribution, Half Life, and Clearance
The volume of distribution of Treprostinil Tillomed is 0.79 L/kg, and its half-life is approximately 1 hour. Its clearance is approximately 0.48 L/hr/kg. It is eliminated primarily by the liver and kidney.
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