Tramesh

Tramesh Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tramesh is a brand name. Its generic name is Tramadol.

Tramesh

Tramesh, (generic name: tramadol hydrochloride), is an opioid medication used to treat moderate to severe pain. It is an opioid agonist, meaning it stimulates opioid receptors in the brain, activating them and producing an analgesic effect. Tramesh also works on serotonin and norepinephrine receptors, further enhancing its pain-relieving effect. Tramesh is available in both immediate-release and extended-release forms.

Uses For Tramesh

Tramesh is prescribed to treat moderate to severe pain in both adults and children, as well as in adolescents between the ages of 12 and 18. It is also used off-label to treat pain associated with fibromyalgia, painful neuropathy, and headaches. Because of its opiate-like effects, Tramesh is sometimes prescribed for the treatment of opioid dependence.

Mechanism Of Action

Tramesh works by binding to opioid receptors in the brain and spinal cord, and increasing the activity of serotonin (which helps reduce the pain signals sent to the brain). Tramesh also binds to the norepinephrine receptor, which further enhances its pain-relieving effect. The combination of its opioid and monoamine agonism is responsible for its analgesic effects.

How Long Does It Take To Work?

Tramesh typically begins to work within 30 minutes to an hour of being taken. The duration of its effects usually last about 4-6 hours. With extended-release tablets, effects may last up to 12 hours.

Absorption

Tramesh is rapidly and completely absorbed from the gut into the blood stream, with peak blood levels occurring one to two hours after ingestion. It is highly soluble in water, and rapidly distributed throughout the body.

Route Of Elimination

Tramesh is broken down and eliminated by the liver and kidneys. About 90% of an administered dose is eliminated via the kidneys, and 10% via the bile. It typically takes 4-6 hours for tramadol to be eliminated from the body.

Dosage

Dosage of Tramesh depends on the task of its use. A starting dose of the medication is usually 25-50mg every four to six hours, for which the maximum dose should not exceed 400mg in a day. For treating breakthrough pain, the dose can be increased to 150-200mg per day. Extended release tablets should be taken once a day, with the maximum dose not exceeding 300mg in a day.

Administration

Tramesh can be taken orally or administered through an IV. Oral tablets and capsules should be taken with food to reduce the risk of gastrointestinal adverse effects. Oral liquid preparations should be administered with a specifically designed measuring device, and not with a regular teaspoon.

Side Effect

Common side effects of Tramesh include nausea, vomiting, drowsiness, dizziness, headache, constipation, and dry mouth. Other side effects may include difficulty urinating, loss of appetite, sweating, confusion, and itchy skin. In some cases, more serious side effects such as respiratory depression, hallucinations, and seizures can occur.

Toxicity

Tramesh is generally considered safe and well-tolerated when used as prescribed. But at higher doses, especially when taken with other medications that also act on the central nervous system, it can be toxic, and may lead to serious respiratory depression, comas, and even death.

Precautions

Tramesh should be taken with caution, especially in individuals with a history of alcohol abuse or addiction, mental illness, thyroid problems, kidney or liver disease, or a history of convulsions, seizures, or head injury. Tramesh should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives or other narcotic medications.

Interaction

Tramesh may interact with certain medications such as anticoagulants, antidepressants, monoamine oxidase inhibitors, drugs for high blood pressure, drugs for mental illness, antihistamines, muscle relaxants, and opioids, increasing the risk of toxicity and other side effects.

Disease Interaction

Tramesh may interact with certain diseases such as seizure disorders, head injury, liver or kidney disease, and respiratory depression, increasing the risk of toxicity and other side effects. Patients with any of these diseases should talk to their doctor before starting tramadol therapy.

Drug Interaction

Tramesh can interact with several drugs, including alcohol, Monoamine Oxidase inhibitors (MAOIs), anticoagulants, sedatives, muscle relaxants, and opioids. These interactions can increase the risk of toxicity and other side effects. Patients should check with their doctor before starting or stopping any medication while taking tramadol.

Food Interactions

Tramesh should be taken with food to reduce the risk of gastrointestinal adverse effects. Grapefruit juice should be avoided when taking tramadol, as it can increase the absorption of the drug and potentially increase its toxicity. Certain foods such as aged cheese, red wine, and pickled or smoked meats can also interact with tramadol.

Pregnancy Use

Tramesh is not recommended for use in pregnant women. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are pregnant or breastfeeding should talk to their doctor before taking tramadol.

Lactation Use

Tramesh should not be used during breastfeeding. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are breastfeeding should talk to their doctor before taking tramadol.

Acute Overdose

Overdose of tramadol can lead to respiratory depression, comas, and even death. Symptoms of an overdose can include pinpoint pupils, confusion, slowed breathing, seizure, and loss of consciousness. Treatment for an overdose may include administration of naloxone, an opioid antagonist, or other supportive care measures.

Contraindication

Tramesh is contraindicated in patients who are hypersensitive to it or any of its components. It is also contraindicated in patients who are taking MAO inhibitors, strong CYP3A4 inhibitors, and certain opioid drugs such as meperidine. Additionally, tramadol should not be taken in combination with alcohol or other CNS depressants.

Use Direction

Tramesh should be taken as directed by a physician. It should be taken with food to reduce the risk of gastrointestinal adverse effects. The dosage of tramadol should be adjusted based on patient’s response and symptoms. It should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives, or other narcotic medications.

Storage Condition

Tramesh should be stored at room temperature in a light-resistant, child-resistant container. It should be kept away from heat and moisture, and out of the reach of children and pets.

Volume Of Distribution

Tramesh has a volume of distribution of 0.4L/kg, meaning that 0.4L of the drug is distributed throughout the body for every kg of the patient’s weight.

Half Life

Tramesh has a half-life of 4-6 hours, meaning it takes 4-6 hours for half of the drug to be eliminated from the body.

Clearance

Tramesh has a clearance rate of 0.11L/kg/hour, meaning that 0.11L of the drug is eliminated from the body every hour for every kg of the patient’s weight.

Here you find in details version of Tramesh

Some Frequently Asked Questions About Tramesh

What is Tramesh?

Tramesh is an opioid-type pain reliever (analgesic) used to treat moderate to moderately severe pain. It is available in both immediate-release and extended-release formulations.

What is the generic name of Tramesh?

Tramesh's generic name is Ultram.

What is the mechanism of action of Tramesh?

Tramesh works by binding to and activating opioid receptors located in the brain, which helps reduce the perception of pain.

Is Tramesh a controlled substance?

Yes, Tramesh is classified as a Schedule IV controlled substance in the United States, suggesting that it has a low potential for abuse.

How fast does Tramesh work?

Tramesh works within 30 minutes of taking a dose and its effects can last up to 4-6 hours.

How should Tramesh be taken?

Tramesh should be taken exactly as prescribed by the doctor. It can be taken with or without food but should not be crushed, split, or chewed before taking.

What are the side effects of Tramesh?

The most common side effects of Tramesh include nausea, vomiting, constipation, headache, dizziness, drowsiness, and dry mouth.

Can I take acetaminophen and Tramesh together?

Yes, acetaminophen and Tramesh can be taken together as long as the total daily dose of acetaminophen does not exceed 4,000 milligrams.

What are the signs of an overdose of Tramesh?

Signs of an overdose of Tramesh include extreme drowsiness, confusion, shallow breathing, faster heart rate, nausea, vomiting, and fainting.

Can Tramesh be used for back pain?

Yes, Tramesh is often prescribed for the treatment of back pain.

Is Tramesh addictive?

Yes, Tramesh can be addictive when taken in large amounts or for long periods of time.

What should I do if I forget to take a dose of Tramesh?

If you forget to take a dose of Tramesh, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can Tramesh be taken with alcohol?

No, Tramesh should not be taken with alcohol as it can increase the risk of side effects such as extreme drowsiness and respiratory depression.

Should I avoid caffeine while taking Tramesh?

Yes, as caffeine can increase the risk of nervousness, difficulty sleeping, and fast or irregular heartbeat.

Is Tramesh safe for long-term use?

Tramesh is generally considered safe for short-term use, but its effects can diminish with long-term use, increasing the risk of addiction and overdose.

Can Tramesh be taken during pregnancy?

Tramesh should not be taken during pregnancy as it can cause harm to the fetus.

Can I take Tramesh if I have a history of drug abuse?

No, Tramesh should not be taken if you have a history of drug abuse as it can be addictive and could cause relapse.

Will Tramesh show up on a drug test?

Yes, Tramesh may show up on a drug test, though the results may vary depending on the type of test.

Can I take Tramesh if I have liver or kidney disease?

Tramesh should be used with caution in patients with a history of liver or kidney disease, as they may be more sensitive to its effects.

Can I take Tramesh with anti-anxiety medications?

No, Tramesh should not be taken with anti-anxiety medications, as it may increase the risk of adverse reactions.

What should I do if I experience any side effects from Tramesh?

If you experience any side effects from Tramesh, contact your doctor as soon as possible.

What other pain relievers can be taken with Tramesh?

Tramesh can be taken with other non-opioid pain relievers such as ibuprofen and acetaminophen.

What is the maximum daily dose of Tramesh?

The maximum daily dose of Tramesh is 400 milligrams per day for adults.

Does Tramesh cause constipation?

Yes, constipation is a common side effect of Tramesh.

Can I take Tramesh and Tramesh Plus together?

No, Tramesh and Tramesh Plus should not be taken together as it may increase the risk of adverse reactions.

Can Tramesh be taken for headaches?

Yes, Tramesh is often prescribed for the treatment of headaches.

Is Tramesh ever prescribed for arthritis?

Yes, Tramesh is sometimes prescribed for the treatment of arthritis.

Does Tramesh interact with other medications?

Yes, Tramesh may interact with other medications, so it is important to discuss any other medications you are taking with your doctor before taking Tramesh.

Can Tramesh be taken for menstrual cramps?

Yes, Tramesh can be prescribed for the treatment of menstrual cramps.

Can Tramesh be crushed for easier swallowing?

No, Tramesh should not be crushed before taking because the medication may be released too quickly, leading to increased risk of side effects.

What other conditions can Tramesh be used to treat?

Tramesh may be prescribed to treat chronic pain, fibromyalgia, and neuropathic pain, among other conditions.

Can I take Tramesh while breastfeeding?

No, Tramesh should not be taken while breastfeeding as it can be passed through breast milk and could cause harm to a nursing baby.

Can Tramesh be taken with anti-depressants?

Yes, Tramesh can be taken with certain types of anti-depressants, but should not be taken with monoamine oxidase inhibitors (MAOIs).

Can Tramesh be taken with vitamins or supplements?

Yes, Tramesh can be taken with certain vitamins and supplements, but it is important to discuss any medications you are taking with your doctor before taking Tramesh.

Can Tramesh be taken with antihistamines?

Yes, Tramesh can be taken with certain antihistamines, but it is important to check with your doctor before taking any medication.

Can I take Tramesh with other pain relievers?

No, Tramesh should not be taken with other opioid-type pain relievers as this increases the risk of adverse reactions and overdose.

Is Tramesh metabolized by the liver?

Yes, Tramesh is metabolized in the liver and it is important to discuss any history of liver or kidney disease with your doctor before taking Tramesh.

How long will Tramesh stay in my system?

Tramesh can stay in the system for up to 24 hours after the last dose.

What should I do if I miss a dose of Tramesh?

If you miss a dose of Tramesh, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.

Can I take Tramesh while taking other medications?

Yes, Tramesh can be taken with certain medications, but it is important to discuss any medications you are taking with your doctor before taking Tramesh.

Does Tramesh affect blood pressure?

Yes, Tramesh may cause an increase in blood pressure, so it is important to talk to your doctor if you have any concerns.

What is Tramesh HCL?

Tramesh HCL (hydrochloride) is a prescription medication used to treat pain. It is available in both immediate-release and extended-release formulations.

What are the withdrawal symptoms of Tramesh?

The withdrawal symptoms of Tramesh may include insomnia, agitation, anxiety, nausea, vomiting, sweating, and runny nose.

Can Tramesh cause hallucinations?

Yes, Tramesh can cause hallucinations, especially at higher doses.

Is Tramesh the same as Vicodin?

No, Tramesh and Vicodin are different medications. Tramesh is an opioid-type pain reliever while Vicodin is a combination of an opioid and acetaminophen.

Can Tramesh be taken with other medications for pain?

Yes, Tramesh can be taken with other medications for pain, but it is important to discuss any medications you are taking with your doctor before taking Tramesh.