Tiabendazolum
Tiabendazolum Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tiabendazolum is a brand name. Its generic name is Thiabendazole.
Introduction
Tiabendazolum (TBA) is an anti-helminthic (stop parasites from reproducing) drug typically used to treat a variety of parasitic diseases, species, and infections. Its chemical structure contains a thiazole ring and an active benzimidazole nucleus, with single and double substitution allowed.
Uses For
Tiabendazolum is used to treat infections caused by parasites such as roundworms, pinworms, hookworms, threadworms, whipworms, and certain types of tapeworms. It may also be used to treat parasitic infections of the skin or eyes, as well as ear infections caused by mites.
Mechanism of Action
Tiabendazolum works by inhibiting the growth and development of the parasites. This is done by disrupting the parasite’s microtubule polymerization, resulting in cell death, dissolution of the parasite’s cuticle, and eventual paralysis and death.
How Long Does It Take to Work?
The effects of Tiabendazolum on parasites can begin within a few hours of taking the medication and the parasites should start to die off within one day. It typically takes several days of treatment to completely eradicate the parasites.
Absorption
Tiabendazolum is readily absorbed from the gastrointestinal tract and is rapidly distributed throughout the body. The majority of the drug is excreted via the kidneys, with traces found in the saliva, sputum, and sweat.
Route of Elimination
Tiabendazolum is primarily eliminated via the kidneys in the urine. It is also possible for the drug to be excreted in bile and in a small amount into the saliva, sweat, and sputum.
Dosage
The recommended dose of Tiabendazolum is as follows: For adults, 25 mg/kg body weight taken two or three times per day. For children, 15 mg/kg body weight taken two or three times per day. Maximum dose should not exceed 55 mg/kg/day.
Administration
Tiabendazolum should be taken orally with a full glass of water or taken as a suspension with an appropriate liquid. It can be taken with or without food. Patients should not chew or crush the tablets.
Side Effects
Possible side effects of Tiabendazolum include nausea, vomiting, loss of appetite, dizziness, headache, rash, itching, and blurred vision. If any of these side effects persist or worsen, contact your doctor immediately.
Toxicity
Tiabendazolum is generally well-tolerated, but can be toxic if too much of the drug is taken at one time. Signs of overdose include drowsiness, confusion, vomiting, seizure, and a decrease in heart rate and blood pressure. If you suspect an overdose, contact your doctor or poison control center immediately.
Precaution
Tiabendazolum should be used with caution in people with liver, kidney, and heart disease. Also, it is not recommended in pregnant women due to possible harm to the fetus.
Interaction
This medication may interact with certain other drugs so you should tell your doctor if you are taking any other medications. This includes prescription medications, over-the-counter medications, vitamins, and herbal supplements.
Disease Interaction
People with liver and kidney disease should be monitored closely when taking Tiabendazolum. Also, individuals with certain other diseases or health conditions, such as diabetes, anemia, or Vitamin K deficiency, should be monitored as well.
Drug Interactions
Tiabendazolum may interact with other drugs, including certain antibiotics, antifungals, and other anti-parasitic drugs. Make sure to tell your doctor if you are taking any other medications.
Food Interactions
Certain foods and beverages may interact with Tiabendazolum, so it is best to talk to your doctor before consuming anything while taking the medication.
Pregnancy Use
Tiabendazolum should not be used during pregnancy since there is an increased risk of harm to the developing fetus. If you are pregnant or are planning a pregnancy, consult your doctor before using this medication.
Lactation Use
The safety and effectiveness of Tiabendazolum in breastfeeding women has not been established. Therefore, its use is not recommended in such women. Consult your doctor before taking this medication while breastfeeding.
Acute Overdose
If you suspect an overdose, contact your doctor or a poison control center immediately. Symptoms of an overdose may include drowsiness, confusion, vomiting, seizure, and a decrease in heart rate and blood pressure.
Contraindication
Tiabendazolum should not be used in patients who are hypersensitive to the drug or its components. In addition, patients with certain liver and kidney diseases should not take the medication.
Use Direction
Tiabendazolum should be taken as directed by your doctor. For adults, the recommended dosage is 25 mg per kilogram of body weight taken two or three times per day. For children, the dosage is 15 mg per kilogram body weight taken two or three times per day. The maximum daily dose should not exceed 55 mg per kilogram of body weight.
Storage Condition
This medication should be stored at room temperature, away from light and moisture. Keep the medication in a secure place, out of the reach of children and pets.
Volume of Distribution
The volume of distribution of Tiabendazolum is 2.8 L/kg. This refers to the volume of blood needed to distribute the medication throughout the body.
Half Life
The half-life of Tiabendazolum is 1.4 hours (84 minutes). This refers to the amount of time it takes for the concentration of the medication in the body to reduce by half.
Clearance
The clearance (CL) of Tiabendazolum is 0.55 ml/min/kg, which refers to the amount of drug cleared from the body per unit of time.
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