Tezesol
Tezesol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Tezesol is a brand name. Its generic name is Monosulfiram.
Tezesol
Tezesol is a drug used to treat alcohol abuse and addiction. It works by inhibiting the breakdown of alcohol in the body, causing unpleasant physical side effects when alcohol is consumed. It is also sometimes used for other medical conditions including Parkinson's disease, chronic heart failure, and amyotrophic lateral sclerosis (ALS).
Uses for Tezesol
Tezesol is most commonly used to help alcoholics limit or quit their drinking. It works by directly inhibiting the breakdown of alcohol, which causes an unpleasant reaction when someone drinks alcohol while taking Tezesol. This reaction includes nausea, vomiting, flushing, headache and rapid heartbeat.
Mechanism of Action
Tezesol works by inhibiting an enzyme in the liver called alcohol dehydrogenase. This enzyme helps break down alcohol to more manageable compounds that can be more easily eliminated from the body. However, when Tezesol is present, it blocks the function of this enzyme, preventing the alcohol from being broken down and allowing it to remain active in the bloodstream for longer.
How Long Does it Take to Work?
Tezesol starts to take effect within 30 minutes of taking the dose. After 2-3 hours, the peak effects will be reached and the effects will remain until 4-6 hours after the dose.
Absorption, Route of Elimination, and Dosage
Tezesol is easily absorbed by the body and is rapidly eliminated from the body through the kidneys. The recommended dosage is 250 mg taken once daily in the morning. Higher doses may be prescribed depending on the individual's response to treatment and medical condition.
Administration
Tezesol should be taken as directed by a healthcare provider. It is usually taken orally with a full glass of water one time every day in the morning. Due to the potential for severe side effects, the dosage should not be exceeded without approval from a healthcare provider.
Side Effect
The most common side effects associated with Tezesol use are nausea, vomiting, flushing, headache, and rapid heartbeat. Other potential side effects include confusion, depression, and dizziness. Severe allergic reactions are also possible.
Toxicity
Tezesol is considered to be generally safe at the recommended doses, however it can be toxic in large doses. Signs of overdose include difficulty breathing, vomiting, and abnormal heart rate.
Precautions
Tezesol should be used with caution in people with mental illness and those with allergies to medications. In addition, this medication should not be used by people who are pregnant or breastfeeding. It should not be taken with alcohol or other drugs that may interact with Tezesol.
Interactions
Tezesol can interact with other medications, including antidepressants, anticonvulsants, and antihistamines. Alcohol and other drugs that can interact with Tezesol should also be avoided. It is important to talk to a healthcare provider before taking any medications while taking Tezesol.
Disease Interactions
Tezesol can interact with certain medical conditions. It may be especially dangerous for people with liver or kidney disease, lung disease, or a history of seizures. It should not be used by people with severe or uncontrolled high blood pressure.
Drug Interactions
Tezesol can interact with several drugs, including antidepressants, anticonvulsants, antipsychotics, and other medications. Interactions can lead to a decreased effectiveness of the drug or an increased risk of side effects. It is important to tell a healthcare provider about all drugs that are being taken before starting Tezesol.
Food Interactions
Tezesol can interact with certain foods, such as grapefruit and other citrus fruits. Eating these foods may lead to an increased risk of side effects. It is important to talk to a healthcare provider before taking Tezesol.
Pregnancy Use
Tezesol should not be used during pregnancy unless the benefits outweigh the potential risks. It is important to talk to a healthcare provider before taking Tezesol while pregnant.
Lactation Use
Tezesol should not be used while breastfeeding due to a lack of safety data. It is important to talk to a healthcare provider before taking Tezesol while breastfeeding.
Acute Overdose
Symptoms of an overdose of Tezesol may include difficulty breathing, vomiting, and abnormal heart rate. If an overdose is suspected, seek medical help immediately.
Contraindication
Tezesol should not be used in people with certain medical conditions, including severe or uncontrolled high blood pressure, liver or kidney disease, lung disease, or a history of seizures. In addition, this drug should also not be taken by people with allergies to this medication or other medications.
Use Direction
Tezesol should be used as directed by a healthcare provider. The recommended dose is 250 mg daily. It is important to take every dose as prescribed and to not skip or miss doses. Alcohol or other drugs that interact with Tezesol should be avoided.
Storage Condition
Tezesol should be stored in a cool, dry place. It should also be kept away from heat, light, and moisture. The tablets should be kept in the original packaging and stored out of reach of children and pets.
Volume of Distribution
The volume of distribution for Tezesol is about 0.2 L/kg.
Half Life
The half life of Tezesol is about 2-3 days.
Clearance
Tezesol has a total clearance of about 0.17 L/hr/kg.
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