Syndol
Syndol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Syndol is a brand name. Its generic name is Tramadol.
Syndol
Syndol, (generic name: tramadol hydrochloride), is an opioid medication used to treat moderate to severe pain. It is an opioid agonist, meaning it stimulates opioid receptors in the brain, activating them and producing an analgesic effect. Syndol also works on serotonin and norepinephrine receptors, further enhancing its pain-relieving effect. Syndol is available in both immediate-release and extended-release forms.
Uses For Syndol
Syndol is prescribed to treat moderate to severe pain in both adults and children, as well as in adolescents between the ages of 12 and 18. It is also used off-label to treat pain associated with fibromyalgia, painful neuropathy, and headaches. Because of its opiate-like effects, Syndol is sometimes prescribed for the treatment of opioid dependence.
Mechanism Of Action
Syndol works by binding to opioid receptors in the brain and spinal cord, and increasing the activity of serotonin (which helps reduce the pain signals sent to the brain). Syndol also binds to the norepinephrine receptor, which further enhances its pain-relieving effect. The combination of its opioid and monoamine agonism is responsible for its analgesic effects.
How Long Does It Take To Work?
Syndol typically begins to work within 30 minutes to an hour of being taken. The duration of its effects usually last about 4-6 hours. With extended-release tablets, effects may last up to 12 hours.
Absorption
Syndol is rapidly and completely absorbed from the gut into the blood stream, with peak blood levels occurring one to two hours after ingestion. It is highly soluble in water, and rapidly distributed throughout the body.
Route Of Elimination
Syndol is broken down and eliminated by the liver and kidneys. About 90% of an administered dose is eliminated via the kidneys, and 10% via the bile. It typically takes 4-6 hours for tramadol to be eliminated from the body.
Dosage
Dosage of Syndol depends on the task of its use. A starting dose of the medication is usually 25-50mg every four to six hours, for which the maximum dose should not exceed 400mg in a day. For treating breakthrough pain, the dose can be increased to 150-200mg per day. Extended release tablets should be taken once a day, with the maximum dose not exceeding 300mg in a day.
Administration
Syndol can be taken orally or administered through an IV. Oral tablets and capsules should be taken with food to reduce the risk of gastrointestinal adverse effects. Oral liquid preparations should be administered with a specifically designed measuring device, and not with a regular teaspoon.
Side Effect
Common side effects of Syndol include nausea, vomiting, drowsiness, dizziness, headache, constipation, and dry mouth. Other side effects may include difficulty urinating, loss of appetite, sweating, confusion, and itchy skin. In some cases, more serious side effects such as respiratory depression, hallucinations, and seizures can occur.
Toxicity
Syndol is generally considered safe and well-tolerated when used as prescribed. But at higher doses, especially when taken with other medications that also act on the central nervous system, it can be toxic, and may lead to serious respiratory depression, comas, and even death.
Precautions
Syndol should be taken with caution, especially in individuals with a history of alcohol abuse or addiction, mental illness, thyroid problems, kidney or liver disease, or a history of convulsions, seizures, or head injury. Syndol should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives or other narcotic medications.
Interaction
Syndol may interact with certain medications such as anticoagulants, antidepressants, monoamine oxidase inhibitors, drugs for high blood pressure, drugs for mental illness, antihistamines, muscle relaxants, and opioids, increasing the risk of toxicity and other side effects.
Disease Interaction
Syndol may interact with certain diseases such as seizure disorders, head injury, liver or kidney disease, and respiratory depression, increasing the risk of toxicity and other side effects. Patients with any of these diseases should talk to their doctor before starting tramadol therapy.
Drug Interaction
Syndol can interact with several drugs, including alcohol, Monoamine Oxidase inhibitors (MAOIs), anticoagulants, sedatives, muscle relaxants, and opioids. These interactions can increase the risk of toxicity and other side effects. Patients should check with their doctor before starting or stopping any medication while taking tramadol.
Food Interactions
Syndol should be taken with food to reduce the risk of gastrointestinal adverse effects. Grapefruit juice should be avoided when taking tramadol, as it can increase the absorption of the drug and potentially increase its toxicity. Certain foods such as aged cheese, red wine, and pickled or smoked meats can also interact with tramadol.
Pregnancy Use
Syndol is not recommended for use in pregnant women. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are pregnant or breastfeeding should talk to their doctor before taking tramadol.
Lactation Use
Syndol should not be used during breastfeeding. It is not known whether the drug is harmful to developing babies or if it passes into breast milk. Women who are breastfeeding should talk to their doctor before taking tramadol.
Acute Overdose
Overdose of tramadol can lead to respiratory depression, comas, and even death. Symptoms of an overdose can include pinpoint pupils, confusion, slowed breathing, seizure, and loss of consciousness. Treatment for an overdose may include administration of naloxone, an opioid antagonist, or other supportive care measures.
Contraindication
Syndol is contraindicated in patients who are hypersensitive to it or any of its components. It is also contraindicated in patients who are taking MAO inhibitors, strong CYP3A4 inhibitors, and certain opioid drugs such as meperidine. Additionally, tramadol should not be taken in combination with alcohol or other CNS depressants.
Use Direction
Syndol should be taken as directed by a physician. It should be taken with food to reduce the risk of gastrointestinal adverse effects. The dosage of tramadol should be adjusted based on patient’s response and symptoms. It should not be taken concomitantly with MAO inhibitors, muscle relaxants, sedatives, or other narcotic medications.
Storage Condition
Syndol should be stored at room temperature in a light-resistant, child-resistant container. It should be kept away from heat and moisture, and out of the reach of children and pets.
Volume Of Distribution
Syndol has a volume of distribution of 0.4L/kg, meaning that 0.4L of the drug is distributed throughout the body for every kg of the patient’s weight.
Half Life
Syndol has a half-life of 4-6 hours, meaning it takes 4-6 hours for half of the drug to be eliminated from the body.
Clearance
Syndol has a clearance rate of 0.11L/kg/hour, meaning that 0.11L of the drug is eliminated from the body every hour for every kg of the patient’s weight.
Here you find in details version of Syndol
Some Frequently Asked Questions About Syndol
What is Syndol?
Syndol is an opioid-type pain reliever (analgesic) used to treat moderate to moderately severe pain. It is available in both immediate-release and extended-release formulations.
What is the generic name of Syndol?
Syndol's generic name is Ultram.
What is the mechanism of action of Syndol?
Syndol works by binding to and activating opioid receptors located in the brain, which helps reduce the perception of pain.
Is Syndol a controlled substance?
Yes, Syndol is classified as a Schedule IV controlled substance in the United States, suggesting that it has a low potential for abuse.
How fast does Syndol work?
Syndol works within 30 minutes of taking a dose and its effects can last up to 4-6 hours.
How should Syndol be taken?
Syndol should be taken exactly as prescribed by the doctor. It can be taken with or without food but should not be crushed, split, or chewed before taking.
What are the side effects of Syndol?
The most common side effects of Syndol include nausea, vomiting, constipation, headache, dizziness, drowsiness, and dry mouth.
Can I take acetaminophen and Syndol together?
Yes, acetaminophen and Syndol can be taken together as long as the total daily dose of acetaminophen does not exceed 4,000 milligrams.
What are the signs of an overdose of Syndol?
Signs of an overdose of Syndol include extreme drowsiness, confusion, shallow breathing, faster heart rate, nausea, vomiting, and fainting.
Can Syndol be used for back pain?
Yes, Syndol is often prescribed for the treatment of back pain.
Is Syndol addictive?
Yes, Syndol can be addictive when taken in large amounts or for long periods of time.
What should I do if I forget to take a dose of Syndol?
If you forget to take a dose of Syndol, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.
Can Syndol be taken with alcohol?
No, Syndol should not be taken with alcohol as it can increase the risk of side effects such as extreme drowsiness and respiratory depression.
Should I avoid caffeine while taking Syndol?
Yes, as caffeine can increase the risk of nervousness, difficulty sleeping, and fast or irregular heartbeat.
Is Syndol safe for long-term use?
Syndol is generally considered safe for short-term use, but its effects can diminish with long-term use, increasing the risk of addiction and overdose.
Can Syndol be taken during pregnancy?
Syndol should not be taken during pregnancy as it can cause harm to the fetus.
Can I take Syndol if I have a history of drug abuse?
No, Syndol should not be taken if you have a history of drug abuse as it can be addictive and could cause relapse.
Will Syndol show up on a drug test?
Yes, Syndol may show up on a drug test, though the results may vary depending on the type of test.
Can I take Syndol if I have liver or kidney disease?
Syndol should be used with caution in patients with a history of liver or kidney disease, as they may be more sensitive to its effects.
Can I take Syndol with anti-anxiety medications?
No, Syndol should not be taken with anti-anxiety medications, as it may increase the risk of adverse reactions.
What should I do if I experience any side effects from Syndol?
If you experience any side effects from Syndol, contact your doctor as soon as possible.
What other pain relievers can be taken with Syndol?
Syndol can be taken with other non-opioid pain relievers such as ibuprofen and acetaminophen.
What is the maximum daily dose of Syndol?
The maximum daily dose of Syndol is 400 milligrams per day for adults.
Does Syndol cause constipation?
Yes, constipation is a common side effect of Syndol.
Can I take Syndol and Syndol Plus together?
No, Syndol and Syndol Plus should not be taken together as it may increase the risk of adverse reactions.
Can Syndol be taken for headaches?
Yes, Syndol is often prescribed for the treatment of headaches.
Is Syndol ever prescribed for arthritis?
Yes, Syndol is sometimes prescribed for the treatment of arthritis.
Does Syndol interact with other medications?
Yes, Syndol may interact with other medications, so it is important to discuss any other medications you are taking with your doctor before taking Syndol.
Can Syndol be taken for menstrual cramps?
Yes, Syndol can be prescribed for the treatment of menstrual cramps.
Can Syndol be crushed for easier swallowing?
No, Syndol should not be crushed before taking because the medication may be released too quickly, leading to increased risk of side effects.
What other conditions can Syndol be used to treat?
Syndol may be prescribed to treat chronic pain, fibromyalgia, and neuropathic pain, among other conditions.
Can I take Syndol while breastfeeding?
No, Syndol should not be taken while breastfeeding as it can be passed through breast milk and could cause harm to a nursing baby.
Can Syndol be taken with anti-depressants?
Yes, Syndol can be taken with certain types of anti-depressants, but should not be taken with monoamine oxidase inhibitors (MAOIs).
Can Syndol be taken with vitamins or supplements?
Yes, Syndol can be taken with certain vitamins and supplements, but it is important to discuss any medications you are taking with your doctor before taking Syndol.
Can Syndol be taken with antihistamines?
Yes, Syndol can be taken with certain antihistamines, but it is important to check with your doctor before taking any medication.
Can I take Syndol with other pain relievers?
No, Syndol should not be taken with other opioid-type pain relievers as this increases the risk of adverse reactions and overdose.
Is Syndol metabolized by the liver?
Yes, Syndol is metabolized in the liver and it is important to discuss any history of liver or kidney disease with your doctor before taking Syndol.
How long will Syndol stay in my system?
Syndol can stay in the system for up to 24 hours after the last dose.
What should I do if I miss a dose of Syndol?
If you miss a dose of Syndol, take it as soon as you remember, but do not double your dose. Call your doctor if you have any questions or concerns.
Can I take Syndol while taking other medications?
Yes, Syndol can be taken with certain medications, but it is important to discuss any medications you are taking with your doctor before taking Syndol.
Does Syndol affect blood pressure?
Yes, Syndol may cause an increase in blood pressure, so it is important to talk to your doctor if you have any concerns.
What is Syndol HCL?
Syndol HCL (hydrochloride) is a prescription medication used to treat pain. It is available in both immediate-release and extended-release formulations.
What are the withdrawal symptoms of Syndol?
The withdrawal symptoms of Syndol may include insomnia, agitation, anxiety, nausea, vomiting, sweating, and runny nose.
Can Syndol cause hallucinations?
Yes, Syndol can cause hallucinations, especially at higher doses.
Is Syndol the same as Vicodin?
No, Syndol and Vicodin are different medications. Syndol is an opioid-type pain reliever while Vicodin is a combination of an opioid and acetaminophen.
Can Syndol be taken with other medications for pain?
Yes, Syndol can be taken with other medications for pain, but it is important to discuss any medications you are taking with your doctor before taking Syndol.