suprane liquidinhalation
suprane liquidinhalation Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? suprane liquidinhalation is a brand name. Its generic name is Desflurane.
Introduction
suprane liquidinhalation (INN) is a potent, nonflammable, highly fluorinated methyl ethyl etherused as an inhalational anesthetic. It is a structural isomer of isoflurane,drug, but as it has a fluorine atom in its molecular structure, its metabolic pathways are more difficult to predict. It has a minimum alveolar concentration of 6.5%.Uses for
suprane liquidinhalation is used as an anesthetic for induction and maintenance of general anesthesia. It provides smooth induction and rapid emergence with minimum cardiopulmonary depression. It has low solubility in blood, resulting in a relatively rapid induction of anesthesia following the administration of an initial dose. suprane liquidinhalation is indicated for adults and children undergoing diagnostic or surgical procedures. It can also be used for induction and maintenance of anesthesia in veterinary species.Mechanism of Action
suprane liquidinhalation binds to the lipid and water components of nerve cells in the brain, reducing their excitability. This alters the electrical signal transmission between the neurons and results in a decreased excitability of the central nervous system, resulting in an anesthetic state.How Long Does It Take to Work?
suprane liquidinhalation usually acts quickly after inhalation, with effects usually seen within one to two minutes and optimal levels of anesthesia achieved within two to five minutes.Absorption
suprane liquidinhalation is rapidly absorbed from the alveoli after inhalation, with peak levels achieved within two to three minutes.Route of Elimination
suprane liquidinhalation is eliminated primarily by exhalation. It is also eliminated by metabolism and renal excretion.Dosage
The recommended dosage of desflurane varies depending on the age and weight of the patient, as well as the procedure being performed. In adults, the recommended initial dose is 0.5-1.5 MAC (minimum alveolar concentration) with the dose range of 0.7-1.3 MAC for total IV anesthetic techniques. For adolescents ages 12-17, the recommended initial dose is 0.5-1 MAC with the dose range of 0.7-1 MAC for total IV anesthetic techniques. For children ages 2-11, the recommended initial dose is 0.25-0.75 MAC with dose range of 0.5-0.75 MAC for total IV anesthetic techniques.Administration
suprane liquidinhalation is typically administered inhalation via an anesthesia machine or vaporizer. It is also available as a premixed solution for IV administration.Side Effect
Common side effects of desflurane include respiratory depression, nausea, and hypotension. Other side effects may include headache, dizziness, restlessness, constipation, dry mouth, and vomiting.Toxicity
The risk of desflurane toxicity is low, as the drug is rapidly eliminated from the body by exhalation and metabolism. suprane liquidinhalation is considered to be safe in the recommended dosage ranges, but should be used cautiously in patients with impaired renal or hepatic function.Precaution
suprane liquidinhalation should be used cautiously in patients with a history of asthma or other respiratory conditions. It should also not be used in patients with a history of cardiac arrhythmias, as it can increase the risk of arrhythmias. Patients should also be monitored for signs of increased intraocular pressure, as desflurane can raise intracranial and intraocular pressures.Interaction
suprane liquidinhalation may interact with other drugs, including barbiturates, opioids, cyclosporine, and anticholinergics. Patients should be monitored for adverse reactions to these interactions.Disease Interaction
suprane liquidinhalation should be used cautiously in patients with certain diseases, including liver or renal disease, pulmonary embolism, hyperkalemia, hypomanic or manic episodes, or a history of anesthetic-related seizures.Drug Interaction
suprane liquidinhalation may interact with other drugs, including barbiturates, opioids, cyclosporine, and anticholinergics. Patients should be monitored for adverse reactions to these interactions.Food Interactions
There are no known food interactions with desflurane.Pregnancy Use
suprane liquidinhalation should be used with caution during pregnancy, as safety has not been established in humans.Lactation Use
suprane liquidinhalation should be used with caution during lactation, as safety has not been established in humans.Acute Overdose
Symptoms of desflurane overdose may include respiratory depression, apnea, bradycardia, hypotension, and cardiac arrest. Treatment is typically supportive and may include mechanical ventilation and medications to reverse the effects of overdose.Contraindication
suprane liquidinhalation should not be used in patients with a known hypersensitivity or allergy to desflurane or any other component of the drug. It should also not be used in patients with renal or hepatic impairment.Use Direction
suprane liquidinhalation should be administered via inhalation or IV according to the indication and dosing guidelines set by the healthcare provider. The drug should be monitored for efficacy and side effects and dosages should be adjusted accordingly.Storage Condition
suprane liquidinhalation should be stored in a cool, dry place at room temperature, away from direct heat and light.Volume of Distribution
The apparent volume of distribution of desflurane is approximately 126 liters.Half-life
The elimination half-life of desflurane is approximately 9 minutes.Clearance
The total body clearance of desflurane is approximately 346 ml/min.Here you find in details version of suprane liquidinhalation
Some Frequently Asked Questions About suprane liquidinhalation
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