Strattera

Strattera Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Strattera is a brand name. Its generic name is Atomoxetine.

Strattera Introduction

Strattera is an active drug ingredient used to treat Attention-Deficit/Hyperactivity Disorder (ADHD) and is also used to treat major depressive disorder (MDD). It was first approved for use in 2002 and is classified as a selective norepinephrine reuptake inhibitor (SNRI). It is marketed under the brand name Strattera.

Uses for Strattera

Strattera is used to treat Attention Deficit/Hyperactivity Disorder (ADHD) in both children and adults. It is also used off-label to treat major depressive disorder (MDD) in adults.

Mechanism of Action

Strattera inhibits the presynaptic reuptake of norepinephrine, resulting in increased extracellular concentrations of norepinephrine. In areas of the brain that control attention and impulsivity, this increased norepinephrine availability can improve cognitive control and lead to reduced symptoms of ADHD.

How Long Does it Take to Work?

The therapeutic effect of Strattera can usually be felt within the first week of treatment, though depending on the patient’s individual response, it may take up to 4 weeks before the full effects are seen.

Absorption

Strattera is rapidly and extensively absorbed after oral administration, with peak plasma concentrations being reached within 1.5 to 2 hours. It is highly bound to plasma proteins.

Route of Elimination

Strattera is mainly eliminated through hepatic metabolism via the cytochrome P450 (CYP) 2D6 isoenzyme. The remainder is eliminated as unchanged drug in the urine and in the feces. The terminal elimination half-life is about 5 hours.

Dosage

Dosage of Strattera will depend on the patient and their condition. Generally, the recommended starting dose for adults is 40mg per day, taken in the morning or evening. For children and adolescents, the recommended starting dose is 0.5mg/kg/day or 40mg/day, whichever is lower. The dose can then be adjusted up to a maximum dose of 18mg/kg/day or 100mg/day, whichever is lower. Strattera should only be taken under the supervision of a healthcare professional.

Administration

Strattera should be taken orally with or without food. It should be taken at the same time each day to maintain an even level of the drug in the body. Strattera should be taken as directed by a healthcare professional.

Side Effect

Common side effects of Strattera include: nausea, decreased appetite, headache, fatigue, insomnia, somnolence, mood shifts, constipation, dry mouth, and decreased sex drive. Rare side effects include: palpitations, arrhythmias, increased blood pressure, increased heart rate, elevated liver enzymes, and rash. Some serious side effects, such as suicidal ideation, can occur, so Strattera should be used with caution.

Toxicity

Strattera is generally well tolerated, but it can cause serious side effects when taken in high doses. Symptoms of overdose can include: nausea, vomiting, diarrhea, restlessness, fever, tremor, seizures, irregular heart rhythm, and coma. If an overdose is suspected, a healthcare professional should be consulted as soon as possible.

Precautions

Strattera should be used with caution in patients who have pre-existing hypertension, heart disease, or any other serious health condition. It should also not be used in combination with monoamine oxidase inhibitors (MAOIs). It should also not be used in pregnancy or breastfeeding unless absolutely necessary, as the risks have not yet been fully investigated.

Interactions

Strattera can interact with other drugs, such as anticoagulants, antihypertensives, and antidepressants. It can also interact with herbal supplements, such as St. John’s Wort. Patients taking Strattera should let their healthcare provider know of any other medications they are taking before beginning treatment.

Disease Interaction

Strattera should be used with caution in patients who have pre-existing hypertension, heart disease, or any other serious health condition. It is important to note that the safety and effectiveness of Strattera has not been established for use in children younger than 6 years of age, so its use in this population should be avoided.

Drug Interaction

Strattera may interact with other drugs, including anticoagulants, antihypertensives, and antidepressants. It may also interact with herbal supplements, such as St. John’s Wort. It is important to consult a healthcare provider before beginning treatment with Strattera to ensure that the medications and supplements being taken do not interact with the drug.

Food Interactions

Strattera may interact with food components, such as grapefruit juice. Patients should consult a healthcare professional before consuming any food or beverage that may interact with Strattera.

Pregnancy Use

Strattera should be used with caution in pregnant women. The safety of Strattera in pregnancy has not yet been established, so its use should be avoided unless absolutely necessary.

Lactation Use

Strattera should be used with caution in breastfeeding women. It has not yet been established whether Strattera is excreted in breast milk, so its use should be avoided unless absolutely necessary.

Acute Overdose

Symptoms of an Strattera overdose can include: nausea, vomiting, diarrhea, restlessness, fever, tremor, seizures, irregular heart rhythm, and coma. A healthcare professional should be consulted immediately if an overdose is suspected.

Contraindication

Strattera should not be used in patients who are using or have taken monoamine oxidase inhibitors (MAOIs) within the past 14 days. It should also not be used in patients who are also taking thioridazine or a tetracyclic antidepressant.

Use Direction

Strattera should be taken as directed by a healthcare professional. It is taken orally with or without food and should be taken at the same time each day. The dose can be adjusted according to the patient's individual response for a maximum dose of 18mg/kg/day or 100mg/day, whichever is lower.

Storage Condition

Strattera should be stored at room temperature in a dry place, away from direct light and moisture. It should not be exposed to extreme heat or cold.

Volume of Distribution

Strattera has a volume of distribution of 0.85L/kg. This means that it distributes widely throughout the body, with concentrations in the brain, liver, lungs, and spleen being particularly high.

Half Life

The terminal elimination half-life of Strattera is about 5 hours. This means that after taking a dose, it will take 5 hours for the concentration of the drug to be reduced by half.

Clearance

Strattera is mainly eliminated through hepatic metabolism via the CYP2D6 isoenzyme, with a small amount being eliminated as unchanged drug in the urine and feces. The clearance of Strattera is 22 mL/min/kg.

Here you find in details version of Strattera

Some Frequently Asked Questions About Strattera

Q1. What is Strattera?

A1. Strattera is an FDA-approved medication used to treat Attention Deficit Hyperactivity Disorder (ADHD) in both adults and children.

Q2.How does Strattera work?

A2.Strattera works by targeting the chemical imbalances in the brain that are associated with ADHD. It works similarly to certain antidepressant medications by increasing the amount of norepinephrine (a neurotransmitter) available in the brain.

Q3.What age can Strattera be taken at?

A3.Strattera can be taken by adults and children who are at least 6 years of age.

Q4.How often do you take Strattera?

A4.Strattera is usually taken once or twice a day. Your doctor or healthcare provider will advise you on the recommended dose.

Q5. Does Strattera cause weight gain?

A5. Strattera may cause weight gain in some people. Your doctor may recommend a diet and exercise program to help manage this.

Q6. What are the common side effects of Strattera?

A6. Common side effects of Strattera include stomach pain, nausea, decreased appetite, and insomnia. Other possible side effects include irritability, changes in mood, headaches, and dizziness.

Q7. How long does it take for Strattera to start working?

A7. It can take up to 4 weeks for Strattera to reach its full effectiveness. It is important to continue taking the medication as prescribed by your doctor during this time.

Q8. Is Strattera a stimulant?

A8.No, Strattera is not a stimulant. It is a non-stimulant medication that works by targeting the chemical imbalances in the brain associated with ADHD.

Q9. Is Strattera safe to take for a long period of time?

A9. Strattera is generally considered safe for long-term use. It is important to follow the instructions of your doctor when taking this medication.

Q10. Does Strattera cause addiction?

A10. Strattera is classified as a controlled substance because it can be habit-forming if taken improperly or by someone other than the person for whom it is prescribed. However, if taken as prescribed its effects should not cause addiction.

Q11. What if I forget to take my Strattera dose?

A11. It is important to take Strattera as prescribed by your doctor. If you forget to take your dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next dose at the regular time.

Q12. Can Strattera be taken with other medications?

A12. Strattera can potentially interact with other medications and substances, so it is important to tell your doctor about all medications, supplements, and vitamins you are taking before starting Strattera. Sometimes a doctor may need to adjust a dose or discontinue use of a medication based on drug interactions.

Q13. Is Strattera a controlled substance?

A13.Yes, Strattera is a controlled substance because it can be habit-forming if taken improperly or by someone other than the person for whom it is prescribed.

Q14. Is Strattera better than other ADHD medications?

A14.Strattera is just one option for treating ADHD. Each person responds differently to different medications, so it is important to talk with your doctor to find the medication that is best for you.

Q15. Are there any non-medication treatments that may help with ADHD symptoms?

A15.Yes, cognitive behavioral therapy (CBT) and behavior modification techniques have been shown to help improve the symptoms of ADHD. It is also important to get plenty of sleep and exercise, as these can help improve focus and attention.

Q16. Does Strattera interact with other drugs?

A16. Strattera can potentially interact with other medications and substances, so it is important to tell your doctor about all medications, supplements, and vitamins you are taking before starting Strattera. Sometimes a doctor may need to adjust a dose or discontinue use of a medication based on drug interactions.

Q17. What should I do if I experience side effects when taking Strattera?

A17.If you experience any side effects, it is important to talk to your doctor. Your doctor may be able to adjust your dose or change medications if necessary.

Q18. Can Strattera affect mood and behavior?

A18.Yes, Strattera can affect mood and behavior. It is important to monitor your mood and behavior while taking the medication and report any changes to a doctor.

Q19. Can Strattera be taken with food?

A19. Yes, Strattera can be taken with or without food. Your doctor will advise you on the best time to take Strattera.

Q20. Does Strattera have any dietary restrictions?

A20. No, there are no dietary restrictions associated with Strattera. However, as with any medication, it is important to follow the instructions of your doctor when taking this medication.

Q21. Can Strattera be taken with other ADHD medications?

A21.Yes, Strattera can be taken with other ADHD medications. Your doctor may recommend a combination of medications to help manage your symptoms.

Q22. Does Strattera interact with alcohol?

A22.Yes, Strattera can interact with alcohol and can increase the risk of side effects. It is important to avoid drinking alcohol while taking Strattera.

Q23. What are the possible side effects of Strattera?

A23.The most common side effects of Strattera include stomach pain, nausea, decreased appetite, and insomnia. Other possible side effects include irritability, mood changes, headache, dizziness, and dry mouth.

Q24. Does Strattera have any serious side effects?

A24. While rare, Strattera can cause serious side effects. It is important to talk to your doctor about any concerns you may have and report any side effects to your doctor.

Q25. Is Strattera used to treat depression?

A25.No, Strattera is not used to treat depression. It is an FDA-approved medication that is used to treat Attention Deficit Hyperactivity Disorder (ADHD).

Q26. Are there any natural alternatives to Strattera?

A26.There are some natural alternatives for treating ADHD, such as dietary changes, exercise, and supplements. However, it is important to speak with your doctor before taking any natural treatments.

Q27. Can Strattera be used to treat anxiety?

A27.No, Strattera is not used to treat anxiety. It is FDA-approved to treat Attention Deficit Hyperactivity Disorder (ADHD) in both adults and children.

Q28. Is Strattera available as a generic medication?

A28.Yes, Strattera is available as a generic medication. Your doctor or healthcare provider can advise you on the generic options available.

Q29. How does Strattera compare to other ADHD medications?

A29.Strattera is one option for treating ADHD. It is important to talk with your doctor to find the medication that is best for you, as each person responds differently to different medications.

Q30. What should I do if I experience difficulty sleeping while taking Strattera?

A30.If you are having difficulty sleeping while taking Strattera, it is important to talk to your doctor. Your doctor may be able to adjust your dose or change medications if necessary.