Sevelamero
Sevelamero Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Sevelamero is a brand name. Its generic name is Sevelamer.
Sevelamero
Sevelamero is a polymeric material used as medication to treat hyperphosphatemia (high phosphorus levels in the blood) in end-stage renal failure. It is an oral phosphorous binder with a low potential for interactions and few adverse reactions, making it suitable for long-term therapy. The medication works by binding phosphorous to it in the gut, preventing it from being reabsorbed and eventually excreted.
Uses for Sevelamero
Sevelamero is used primarily for hyperphosphatemia. It is given orally and binds phosphorous directly in the gut, which helps to reduce blood levels of the nutrient. This medication is primarily used for patients who have kidney failure or are on dialysis. It may also be prescribed for those with chronic kidney disease who are not on dialysis.
Mechanism of Action
Sevelamero works by binding phosphorous in the gut. This process prevents the phosphorous from being reabsorbed and eventually excreted. It binds to the phosphorous in the gastrointestinal tract and does not pass into the bloodstream, thus reducing the levels of phosphorous in the blood.
How Long Does it Take to Work?
The effects of Sevelamero can be seen within 1-2 weeks, though it can take up to 6 weeks to reach an optimum level. The benefits of Sevelamero are cumulative, so periodic monitoring is necessary.
Absorption, Route of Elimination, Dosage, Administration
Sevelamero is not absorbed by the body and is excreted unchanged. It is usually administered orally in a tablet or suspension form. The standard dosage is 800 mg taken orally twice a day, but this can be adjusted depending on serum phosphorus levels or other factors such as weight or age.
Side Effects
Common side effects of Sevelamero include nausea, diarrhea, abdominal pain, and constipation. Rare, more serious side effects include an allergic reaction and, very rarely, kidney issues. If any of these symptoms occur, seek immediate medical attention.
Toxicity
Sevelamero is generally well tolerated, and serious toxicity is rare. However, it should not be taken by patients with allergies to sevelamer or any components of the formulation. Also, it is important to monitor serum phosphorus levels during therapy to avoid potential toxicity.
Precautions
It is important to let your doctor know if you have any allergies or health concerns before starting Sevelamero treatment. Furthermore, patients using this drug should be monitored regularly for signs of kidney toxicity or adverse reactions.
Interactions
Sevelamero is unlikely to interact with other medications and does not bind other vitamins or minerals. However, it may interact with calcium-containing antacids and should not be taken at the same time as other phosphorous binders. It is important to inform your healthcare provider of all the medications you are taking before beginning Sevelamero therapy.
Disease Interactions
Sevelamero may interfere with phosphorus balance in patients with liver disease or chronic kidney failure, and should be used cautiously in these patients. Patients with severe kidney failure may require adjusted dose and careful monitoring. Patients with hypercalcemia should be closely monitored while taking Sevelamero.
Drug Interactions
Sevelamero has no known drug interactions, though it is important to inform your prescribing doctor or pharmacist of all the medications you take before beginning this treatment. Additionally, it is important not to take it with other phosphorous binders as this may induce adverse reactions or interfere with the drug’s ability to bind phosphorous.
Food Interactions
Sevelamero has no known interaction with food. It is advisable to take this medication without food, as it may not be as effective when taken with food. Additionally, it is important to talk to your doctor about when it is best to take Sevelamero, as certain foods may cause a decrease in the absorption of the medication.
Pregnancy Use
Sevelamero is not recommended for use in pregnant women, as its safety in this population has not been established. If you are pregnant, talk to your doctor about the risks of taking this drug. Additionally, if you become pregnant while taking Sevelamero, it is essential to tell your doctor right away.
Lactation Use
Sevelamero is not recommended for use in breastfeeding women, as its safety in this population has not been established. If you are breastfeeding, talk to your doctor about the risks of taking this drug. Additionally, if you become pregnant while taking Sevelamero, it is essential to tell your doctor right away.
Acute Overdose
If an overdose is suspected, contact a healthcare provider immediately. Symptoms of an acute overdose may include nausea, vomiting, abdominal pain, and diarrhoea. Treatment of an overdose includes supportive care and gastric lavage.
Contraindication
Sevelamero is contraindicated in patients with hypersensitivity to sevelamer or any components of the formulation. Additionally, it is not recommended for use in pregnant or breastfeeding women.
Use Direction
Sevelamero should be taken as prescribed by your doctor. It is usually taken twice daily, with or without food. The dosage may be altered depending on your age, weight, and serum phosphorus levels. It is important to take Sevelamero exactly as prescribed and to follow all instructions given by your doctor.
Storage Condition
Store Sevelamero tablets at room temperature away from direct light and moisture. Keep this and all medication away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
Volume of Distribution, Half Life, Clearance
The volume of distribution of Sevelamero is approximately 0.13 L/kg. Its elimination half-life is approximately 3 hours. Its clearance rate is unknown.
Here you find in details version of Sevelamero
Some Frequently Asked Questions About Sevelamero
.What is Sevelamero?
Sevelamero is a medication used to lower the level of phosphate in people with chronic kidney disease who are on dialysis.
What does Sevelamero do?
Sevelamero binds phosphate in the stomach and prevents it from being absorbed into the body, thus reducing serum phosphate levels.
How is Sevelamero taken?
Sevelamero is available as an oral tablet or powder and is taken before meals with a full glass of water.
What are the side effects of Sevelamero?
common side effects of Sevelamero include nausea, constipation, vomiting, and diarrhea. More serious side effects include shortness of breath, difficulty swallowing, swelling of the face, throat, or tongue, and hives.
How long does Sevelamero take to work?
Sevelamero begins to work immediately so patients may begin to see changes in their blood phosphorus levels within about two weeks.
How effective is Sevelamero?
Sevelamero has been found to be effective in reducing serum phosphorus levels in patients with chronic kidney disease.
Is there anyone who should not take Sevelamero?
Sevelamero is not recommended for patients who have any type of allergies to the active ingredient. It is also not recommended for people with a history of kidney stones or anemia.
Does Sevelamero interact with any other medications?
Yes. Sevelamero can interact with certain antibiotics, antacids, and calcium supplements. It is important to discuss all medications with your doctor before taking Sevelamero.
What if I miss a dose of Sevelamero?
If you miss a dose of Sevelamero, take it as soon as you remember and then resume your regular dosing schedule. Do not take two doses at once.
Are there any dietary restrictions while taking Sevelamero?
Yes. While taking Sevelamero, it is important to follow a low-phosphorus diet and limit your intake of phosphorous-containing dairy products, proteins, and grains.
Are there any alternatives to Sevelamero?
Yes. Other phosphate binders such as calcium acetate and lanthanum carbonate can be used to reduce blood phosphorus levels in chronic kidney disease patients.
What should I do if I experience an allergic reaction to Sevelamero?
If you experience any signs of an allergic reaction, such as rash, hives, swelling, or difficulty breathing, seek medical attention immediately.
What should I do if I experience nausea or vomiting with Sevelamero?
If you experience nausea or vomiting with Sevelamero, it is important to remain hydrated. It may also help to take your Sevelamero dose with food.
What should I do if I experience constipation while taking Sevelamero?
If you experience constipation while taking Sevelamero it is important to drink plenty of fluids and eat a high-fiber diet. It may also help to increase your exercise level.
What should I do if I forget to take my dose of Sevelamero?
If you forget to take your dose of Sevelamero, take it as soon as you remember and then resume your regular dosing schedule. Do not take two doses at once.
Should I take Sevelamero with or without food?
Sevelamero is typically taken with a full glass of water before meals. If nausea or vomiting occurs, it may help to take the medication with food.
Is Sevelamero safe to use during pregnancy?
Sevelamero is not recommended during pregnancy. It is important to discuss your treatment options with your doctor before taking Sevelamero.
Can I eat dairy products while taking Sevelamero?
It is important to limit your intake of dairy products while taking Sevelamero as they can contain high amounts of phosphorous. It is important to maintain a low-phosphorus diet while taking this medication.
What should I do if I experience side effects while taking Sevelamero?
If you experience any side effects while taking Sevelamero, it is important to contact your doctor or healthcare provider. They may be able to adjust your dosage or suggest alternative treatments.
Does Sevelamero have any drug interactions?
Yes. Sevelamero can interact with certain antibiotics, antacids, and calcium supplements. It is important to discuss all medications with your doctor before taking Sevelamero.
How often do I need to take Sevelamero?
It is usually recommended to take Sevelamero three times a day, spaced evenly throughout the day before meals with 8 ounces of liquid.
What is the dosage for Sevelamero?
The usual starting dose of Sevelamero is 800-1600 mg taken three times a day. Your exact dosage will depend on various factors such as your age, weight, and medical condition.
How long do I need to take Sevelamero?
The length of treatment depends on the individual, though it can be taken for long-term treatment. It is important to discuss a timeline for treatment with your doctor.
What should I tell my doctor before taking Sevelamero?
It is important to inform your doctor of any allergies, medications that you are taking, or any other medical conditions before taking Sevelamero.
Can I take calcium supplements while taking Sevelamero?
No. It is important to avoid taking calcium supplements while taking Sevelamero as they can interact with the medication.
Are there any natural alternatives to Sevelamero?
Yes, there are several natural alternatives to Sevelamero such as seaweed extracts, alginates, and magnesium citrate. It is important to discuss these alternatives with your doctor before taking.
Can Sevelamero be taken with other medications?
Yes, Sevelamero can be taken with other medications, however it is important to discuss all medications with your doctor to avoid any potential interactions.
Can Sevelamero be used in people with impaired renal function?
Yes, Sevelamero can be used in people with impaired renal function, however it is important to discuss the risks and benefits of taking the medication with your doctor.
What is the difference between Sevelamero and Lanthanum?
Sevelamero and Lanthanum are both phosphate binders used to reduce blood phosphate levels in people with chronic kidney disease. Sevelamero binds phosphate in the stomach and lanthanum binds phosphate in the small intestine.
What is the difference between dialysis and Sevelamero?
Dialysis is a technique used to remove waste products and excess fluid from the blood in people with kidney failure. Sevelamero is a medication used to lower the level of phosphate in people with chronic kidney disease who are on dialysis.
Are there any foods that should be avoided while taking Sevelamero?
Yes. It is important to avoid foods that are high in phosphorous such as dairy products, proteins, and grains while taking Sevelamero.
Can I drink alcohol while taking Sevelamero?
It is not advised to drink alcohol while taking Sevelamero as it can increase the risk of certain side effects. It is important to discuss alcohol consumption with your doctor.
Can Sevelamero be taken with antacids?
Yes, Sevelamero can be taken with antacids, however it is important to discuss all medications with your doctor to reduce the risk of any interactions.
Can Sevelamero be taken with antibiotics?
Yes, Sevelamero can be taken with antibiotics, however it is important to discuss all medications with your doctor to reduce the risk of any interactions.
Does Sevelamero have any harmful side effects?
Sevelamero can cause serious side effects which include shortness of breath, difficulty swallowing, swelling of the face, throat, or tongue, and hives. It is important to contact your physician immediately if any of these side effects occur.
How often should my phosphate levels be monitored while taking Sevelamero?
It is important to have your phosphate levels monitored regularly while taking Sevelamero. Your physician will determine the frequency of monitoring based on your individual needs.
What is the cost of Sevelamero?
The cost of Sevelamero can vary depending on your insurance coverage. It is important to check with your provider for current pricing information.
Can Sevelamero be taken long-term?
Yes, Sevelamero can be taken long-term, however it is important to discuss all risks and benefits with your doctor.
Can Sevelamero be taken with other medications for kidney disease?
Yes, Sevelamero can be taken with other medications for kidney disease, however it is important to discuss all medications with your doctor to reduce the risk of any interactions.
Is Sevelamero available in generic form?
Yes, Sevelamero is available in generic form. However, it is important to check with your pharmacist to ensure that you are receiving the generic form of the medication.