Sevel
Sevel Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Sevel is a brand name. Its generic name is Sevelamer.
Sevel
Sevel is a polymeric material used as medication to treat hyperphosphatemia (high phosphorus levels in the blood) in end-stage renal failure. It is an oral phosphorous binder with a low potential for interactions and few adverse reactions, making it suitable for long-term therapy. The medication works by binding phosphorous to it in the gut, preventing it from being reabsorbed and eventually excreted.
Uses for Sevel
Sevel is used primarily for hyperphosphatemia. It is given orally and binds phosphorous directly in the gut, which helps to reduce blood levels of the nutrient. This medication is primarily used for patients who have kidney failure or are on dialysis. It may also be prescribed for those with chronic kidney disease who are not on dialysis.
Mechanism of Action
Sevel works by binding phosphorous in the gut. This process prevents the phosphorous from being reabsorbed and eventually excreted. It binds to the phosphorous in the gastrointestinal tract and does not pass into the bloodstream, thus reducing the levels of phosphorous in the blood.
How Long Does it Take to Work?
The effects of Sevel can be seen within 1-2 weeks, though it can take up to 6 weeks to reach an optimum level. The benefits of Sevel are cumulative, so periodic monitoring is necessary.
Absorption, Route of Elimination, Dosage, Administration
Sevel is not absorbed by the body and is excreted unchanged. It is usually administered orally in a tablet or suspension form. The standard dosage is 800 mg taken orally twice a day, but this can be adjusted depending on serum phosphorus levels or other factors such as weight or age.
Side Effects
Common side effects of Sevel include nausea, diarrhea, abdominal pain, and constipation. Rare, more serious side effects include an allergic reaction and, very rarely, kidney issues. If any of these symptoms occur, seek immediate medical attention.
Toxicity
Sevel is generally well tolerated, and serious toxicity is rare. However, it should not be taken by patients with allergies to sevelamer or any components of the formulation. Also, it is important to monitor serum phosphorus levels during therapy to avoid potential toxicity.
Precautions
It is important to let your doctor know if you have any allergies or health concerns before starting Sevel treatment. Furthermore, patients using this drug should be monitored regularly for signs of kidney toxicity or adverse reactions.
Interactions
Sevel is unlikely to interact with other medications and does not bind other vitamins or minerals. However, it may interact with calcium-containing antacids and should not be taken at the same time as other phosphorous binders. It is important to inform your healthcare provider of all the medications you are taking before beginning Sevel therapy.
Disease Interactions
Sevel may interfere with phosphorus balance in patients with liver disease or chronic kidney failure, and should be used cautiously in these patients. Patients with severe kidney failure may require adjusted dose and careful monitoring. Patients with hypercalcemia should be closely monitored while taking Sevel.
Drug Interactions
Sevel has no known drug interactions, though it is important to inform your prescribing doctor or pharmacist of all the medications you take before beginning this treatment. Additionally, it is important not to take it with other phosphorous binders as this may induce adverse reactions or interfere with the drug’s ability to bind phosphorous.
Food Interactions
Sevel has no known interaction with food. It is advisable to take this medication without food, as it may not be as effective when taken with food. Additionally, it is important to talk to your doctor about when it is best to take Sevel, as certain foods may cause a decrease in the absorption of the medication.
Pregnancy Use
Sevel is not recommended for use in pregnant women, as its safety in this population has not been established. If you are pregnant, talk to your doctor about the risks of taking this drug. Additionally, if you become pregnant while taking Sevel, it is essential to tell your doctor right away.
Lactation Use
Sevel is not recommended for use in breastfeeding women, as its safety in this population has not been established. If you are breastfeeding, talk to your doctor about the risks of taking this drug. Additionally, if you become pregnant while taking Sevel, it is essential to tell your doctor right away.
Acute Overdose
If an overdose is suspected, contact a healthcare provider immediately. Symptoms of an acute overdose may include nausea, vomiting, abdominal pain, and diarrhoea. Treatment of an overdose includes supportive care and gastric lavage.
Contraindication
Sevel is contraindicated in patients with hypersensitivity to sevelamer or any components of the formulation. Additionally, it is not recommended for use in pregnant or breastfeeding women.
Use Direction
Sevel should be taken as prescribed by your doctor. It is usually taken twice daily, with or without food. The dosage may be altered depending on your age, weight, and serum phosphorus levels. It is important to take Sevel exactly as prescribed and to follow all instructions given by your doctor.
Storage Condition
Store Sevel tablets at room temperature away from direct light and moisture. Keep this and all medication away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
Volume of Distribution, Half Life, Clearance
The volume of distribution of Sevel is approximately 0.13 L/kg. Its elimination half-life is approximately 3 hours. Its clearance rate is unknown.
Here you find in details version of Sevel
Some Frequently Asked Questions About Sevel
.What is Sevel?
Sevel is a medication used to lower the level of phosphate in people with chronic kidney disease who are on dialysis.
What does Sevel do?
Sevel binds phosphate in the stomach and prevents it from being absorbed into the body, thus reducing serum phosphate levels.
How is Sevel taken?
Sevel is available as an oral tablet or powder and is taken before meals with a full glass of water.
What are the side effects of Sevel?
common side effects of Sevel include nausea, constipation, vomiting, and diarrhea. More serious side effects include shortness of breath, difficulty swallowing, swelling of the face, throat, or tongue, and hives.
How long does Sevel take to work?
Sevel begins to work immediately so patients may begin to see changes in their blood phosphorus levels within about two weeks.
How effective is Sevel?
Sevel has been found to be effective in reducing serum phosphorus levels in patients with chronic kidney disease.
Is there anyone who should not take Sevel?
Sevel is not recommended for patients who have any type of allergies to the active ingredient. It is also not recommended for people with a history of kidney stones or anemia.
Does Sevel interact with any other medications?
Yes. Sevel can interact with certain antibiotics, antacids, and calcium supplements. It is important to discuss all medications with your doctor before taking Sevel.
What if I miss a dose of Sevel?
If you miss a dose of Sevel, take it as soon as you remember and then resume your regular dosing schedule. Do not take two doses at once.
Are there any dietary restrictions while taking Sevel?
Yes. While taking Sevel, it is important to follow a low-phosphorus diet and limit your intake of phosphorous-containing dairy products, proteins, and grains.
Are there any alternatives to Sevel?
Yes. Other phosphate binders such as calcium acetate and lanthanum carbonate can be used to reduce blood phosphorus levels in chronic kidney disease patients.
What should I do if I experience an allergic reaction to Sevel?
If you experience any signs of an allergic reaction, such as rash, hives, swelling, or difficulty breathing, seek medical attention immediately.
What should I do if I experience nausea or vomiting with Sevel?
If you experience nausea or vomiting with Sevel, it is important to remain hydrated. It may also help to take your Sevel dose with food.
What should I do if I experience constipation while taking Sevel?
If you experience constipation while taking Sevel it is important to drink plenty of fluids and eat a high-fiber diet. It may also help to increase your exercise level.
What should I do if I forget to take my dose of Sevel?
If you forget to take your dose of Sevel, take it as soon as you remember and then resume your regular dosing schedule. Do not take two doses at once.
Should I take Sevel with or without food?
Sevel is typically taken with a full glass of water before meals. If nausea or vomiting occurs, it may help to take the medication with food.
Is Sevel safe to use during pregnancy?
Sevel is not recommended during pregnancy. It is important to discuss your treatment options with your doctor before taking Sevel.
Can I eat dairy products while taking Sevel?
It is important to limit your intake of dairy products while taking Sevel as they can contain high amounts of phosphorous. It is important to maintain a low-phosphorus diet while taking this medication.
What should I do if I experience side effects while taking Sevel?
If you experience any side effects while taking Sevel, it is important to contact your doctor or healthcare provider. They may be able to adjust your dosage or suggest alternative treatments.
Does Sevel have any drug interactions?
Yes. Sevel can interact with certain antibiotics, antacids, and calcium supplements. It is important to discuss all medications with your doctor before taking Sevel.
How often do I need to take Sevel?
It is usually recommended to take Sevel three times a day, spaced evenly throughout the day before meals with 8 ounces of liquid.
What is the dosage for Sevel?
The usual starting dose of Sevel is 800-1600 mg taken three times a day. Your exact dosage will depend on various factors such as your age, weight, and medical condition.
How long do I need to take Sevel?
The length of treatment depends on the individual, though it can be taken for long-term treatment. It is important to discuss a timeline for treatment with your doctor.
What should I tell my doctor before taking Sevel?
It is important to inform your doctor of any allergies, medications that you are taking, or any other medical conditions before taking Sevel.
Can I take calcium supplements while taking Sevel?
No. It is important to avoid taking calcium supplements while taking Sevel as they can interact with the medication.
Are there any natural alternatives to Sevel?
Yes, there are several natural alternatives to Sevel such as seaweed extracts, alginates, and magnesium citrate. It is important to discuss these alternatives with your doctor before taking.
Can Sevel be taken with other medications?
Yes, Sevel can be taken with other medications, however it is important to discuss all medications with your doctor to avoid any potential interactions.
Can Sevel be used in people with impaired renal function?
Yes, Sevel can be used in people with impaired renal function, however it is important to discuss the risks and benefits of taking the medication with your doctor.
What is the difference between Sevel and Lanthanum?
Sevel and Lanthanum are both phosphate binders used to reduce blood phosphate levels in people with chronic kidney disease. Sevel binds phosphate in the stomach and lanthanum binds phosphate in the small intestine.
What is the difference between dialysis and Sevel?
Dialysis is a technique used to remove waste products and excess fluid from the blood in people with kidney failure. Sevel is a medication used to lower the level of phosphate in people with chronic kidney disease who are on dialysis.
Are there any foods that should be avoided while taking Sevel?
Yes. It is important to avoid foods that are high in phosphorous such as dairy products, proteins, and grains while taking Sevel.
Can I drink alcohol while taking Sevel?
It is not advised to drink alcohol while taking Sevel as it can increase the risk of certain side effects. It is important to discuss alcohol consumption with your doctor.
Can Sevel be taken with antacids?
Yes, Sevel can be taken with antacids, however it is important to discuss all medications with your doctor to reduce the risk of any interactions.
Can Sevel be taken with antibiotics?
Yes, Sevel can be taken with antibiotics, however it is important to discuss all medications with your doctor to reduce the risk of any interactions.
Does Sevel have any harmful side effects?
Sevel can cause serious side effects which include shortness of breath, difficulty swallowing, swelling of the face, throat, or tongue, and hives. It is important to contact your physician immediately if any of these side effects occur.
How often should my phosphate levels be monitored while taking Sevel?
It is important to have your phosphate levels monitored regularly while taking Sevel. Your physician will determine the frequency of monitoring based on your individual needs.
What is the cost of Sevel?
The cost of Sevel can vary depending on your insurance coverage. It is important to check with your provider for current pricing information.
Can Sevel be taken long-term?
Yes, Sevel can be taken long-term, however it is important to discuss all risks and benefits with your doctor.
Can Sevel be taken with other medications for kidney disease?
Yes, Sevel can be taken with other medications for kidney disease, however it is important to discuss all medications with your doctor to reduce the risk of any interactions.
Is Sevel available in generic form?
Yes, Sevel is available in generic form. However, it is important to check with your pharmacist to ensure that you are receiving the generic form of the medication.