Savella Titration Pack
Savella Titration Pack Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Savella Titration Pack is a brand name. Its generic name is Milnacipran.
Savella Titration Pack
Savella Titration Pack is an antidepressant medication that belongs to the family of medications known as serotonin and norepinephrine reuptake inhibitors (SNRIs). It is used in adults to treat major depressive disorder.
Uses for
Savella Titration Pack is used to treat the symptoms of major depressive disorder. It may improve how you feel, your energy level, and your ability to function day-to-day. This medication should not be used to treat anxiety, and it is not for use in children and adolescents.
Mechanism of Action
Savella Titration Pack acts by raising the levels of three different neurotransmitters: serotonin, norepinephrine, and dopamine in the brain. Specifically, it blocks the reuptake of serotonin and norepinephrine, preventing them from being recycled back into the brain's nerve cells, thus increasing their availability for neurotransmission. Savella Titration Pack also stimulates post-synaptic α2-adrenoceptor responses.
How Long Does it Take to Work?
Savella Titration Pack typically starts to work within 1-2 weeks, but it can take up to 6 weeks for the full benefits of the medication to be realized. It is important to stay patient and follow your doctor’s instructions when taking Savella Titration Pack so that you can maximize its effectiveness.
Absorption
Savella Titration Pack is absorbed quickly and completely after oral administration. The maximum concentration of Savella Titration Pack is reached in about 2 hours.
Route of Elimination
Savella Titration Pack is rapidly eliminated with most of the drug being metabolized and eliminated in the urine and a small amount being eliminated in the feces. The elimination half-life of the drug is about 5 hours.
Dosage
The dose for Savella Titration Pack depends on the individual patient's clinical status and the severity of symptoms while taking it. The recommended starting dose is 12.5 mg twice a day. The dose may be gradually increased up to 100 mg twice a day as tolerated. It is important to follow your doctor’s instructions for taking Savella Titration Pack and to continue to take the same dose for at least 4 weeks before increasing it.
Administration
Savella Titration Pack is taken orally, usually twice daily. It can be taken with or without food. It is important to take the medication consistently in order to get the most benefit from it.
Side Effects
Common side effects include headache, dry mouth, constipation, dizziness, nausea, fatigue, and sweating. Less common side effects can include tingling or numbness in the extremities, blurred vision, and difficulty sleeping.
Toxicity
Savella Titration Pack overdose can lead to high blood pressure, heart rate, and body temperature as well as an increased risk of seizures. If any of these side effects occur, seek medical help immediately.
Precaution
Before taking Savella Titration Pack, it is important to tell your doctor if you have any of the following: liver or kidney disease, bleeding disorder, heart disease, a history of seizures, a history of drug abuse, or an allergy to this or any other medications.
Interaction
Savella Titration Pack may interact with other medications, herbal supplements, or vitamins. Before taking Savella Titration Pack, tell your doctor about any other medications you are taking, as some of them may interact.
Disease Interaction
Patients with certain medical conditions, such as hypertension, kidney disease, or glaucoma should use Savella Titration Pack with caution as it can worsen the effects of the disease.
Drug Interaction
Savella Titration Pack may interact with certain drugs such as monoamine oxidase inhibitors (MAOIs) and other SSRIs. Always speak with a healthcare professional before taking any medications together.
Food Interactions
Savella Titration Pack does not need to be taken with food because it is absorbed quickly and completely after oral administration. However, drinking alcohol is not recommended while taking Savella Titration Pack as it can increase the severity of side effects.
Pregnancy Use
The use of Savella Titration Pack during pregnancy is not recommended. This is because there is limited data available on the safety of the drug for use in pregnant women.
Lactation Use
It is not known if Savella Titration Pack is safe for use in women who are breastfeeding. It is recommended that women who are breastfeeding do not take Savella Titration Pack.
Acute Overdose
An overdose of Savella Titration Pack can lead to severe and life-threatening symptoms and should always be treated as a medical emergency. Symptoms of an overdose can include nausea, vomiting, abdominal pain, confusion, changes in heart rate, seizures, coma, and death.
Contraindication
Savella Titration Pack should not be taken by patients with an allergy to it or to any of its components. It should also not be taken by patients with a history of mania or severe depression. Patients with a history of seizures should also not take Savella Titration Pack.
Use Direction
Savella Titration Pack should be taken exactly as prescribed by your doctor. It is important to take the medication with or without food at the same time every day, in order to get the most benefit from it. It is also important to not skip doses or to stop taking the medication abruptly as this can make the symptoms of depression worse.
Storage Condition
Savella Titration Pack should be stored at room temperature away from direct light and moisture. Keep the medication away from children and pets.
Volume of Distribution
The apparent volume of distribution for Savella Titration Pack is approximately 152 L after a single dose and 109 L after multiple doses.
Half Life
The elimination half-life of Savella Titration Pack is approximately 5 hours.
Clearance
The renal clearance of Savella Titration Pack is estimated to be 17 L/h with a mean elimination half-life of about 5 hours.
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