Roxit
Roxit Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Roxit is a brand name. Its generic name is Roxatidine.
Roxit: Introduction
Roxit is an H2 receptor antagonist used to reduce the production of stomach acid. It acts on histamine receptors in the stomach to reduce acid secretion, and can be used to treat and prevent gastroesophageal reflux disease (GERD) and peptic ulcers. It is also used to help reduce the symptoms of gastroesophageal reflux disease (GERD) and to heal ulcers of the stomach and intestines.
Uses of Roxit
Roxit is used to:
- Reduce and control the amount of stomach acid, helping to relieve the symptoms of gastroesophageal reflux disease (GERD).
- Prevent and treat peptic ulcers.
- Reduce the risk of recurrence of peptic ulcers or ulcer symptoms in people taking NSAIDs (non-steroidal anti-inflammatory drugs).
Mechanism of Action
Roxit acts as a histamine H2-receptor antagonist. It binds to the histamine H2-receptors in the stomach, which results in a reduced production of stomach acid. This reduces the symptoms of GERD and can help to heal peptic ulcers.
How Long Does It Take to Work?
Roxit usually starts to work within 4 to 8 hours of taking a dose. However, it may take up to 4 weeks for it to start working and to achieve its maximum effects.
Absorption
Roxit is well absorbed from the gastrointestinal tract, with peak concentrations reached in 1.5 to 3 hours.
Route of Elimination
Roxit is eliminated primarily in the feces as unchanged drug and metabolites.
Dosage
The recommended dose of Roxit is 75 mg (rounded off) taken twice daily.
Administration
Roxit should be taken with a meal and a full glass of water.
Side Effects
Common side effects of Roxit include:
- Headache
- Dizziness
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Constipation
- Fatigue
- Insomnia
- Skin rash
Toxicity
At present, there is no known human toxicity associated with Roxit. However, it is unclear if high doses over long periods of time can cause harm. It is important to follow dosage and usage instructions carefully.
Precautions
It is important to tell your doctor and pharmacist what prescription and nonprescription medications and vitamins you are taking or plan to take. This can help to reduce the risk of serious drug interactions. It is also important to inform your healthcare provider if you have any known allergies to medications.
Interactions
Roxit may interact with other medications, including erythromycin, warfarin, cimetidine, quinupristin, and theophylline. It is important to tell your doctor and pharmacist what prescription and nonprescription medications and vitamins you are taking or plan to take. This can help to reduce the risk of serious drug interactions.
Disease Interactions
Roxit may interact with certain conditions, including kidney disease, liver disease, and porphyria. Tell your doctor about any medical conditions you may have before taking this medication.
Drug Interaction
Roxit may interact with certain medications, such as erythromycin, warfarin, cimetidine, quinupristin, and theophylline. Tell your doctor and pharmacist what prescription and non-prescription medications and vitamins you are taking or plan to take.
Food Interaction
Roxit is best taken with food or milk to help reduce potential stomach irritation. Alcohol should be avoided when taking Roxit.
Pregnancy Use
Roxit is not recommended for pregnant women due to lack of research on its safety. Consult your doctor before taking this medication.
Lactation Use
Roxit passes into breast milk but is not recommended while breastfeeding due to the lack of research on its safety. Consult your doctor before taking this medication.
Acute Overdose
Symptoms of an acute overdose of Roxit may include headache, dizziness, nausea, vomiting, abdominal pain, and constipation. If these symptoms occur, seek medical help immediately.
Contraindication
Roxit is contraindicated in patients with known hypersensitivity to the drug or any of its ingredients. It is also contraindicated in patients with severe liver dysfunction.
Use Direction
Roxit should be taken with food or milk and a full glass of water. It is important to take it as prescribed by your doctor and not to skip doses. Do not take more of the medication than prescribed and do not stop taking the medication without consulting your doctor. It may take several weeks before you start to feel the full benefits of the medication.
Storage Condition
Roxit should be stored at room temperature, away from moisture and light. Keep out of reach of children.
Volume of Distribution
The volume of distribution of Roxit is approximately 11 L/kg.
Half Life
The elimination half-life of Roxit is approximately 2.3 hours.
Clearance
The clearance of Roxit is approximately 18.7 mL/min/kg.
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