Riloric
Riloric Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Riloric is a brand name. Its generic name is Allopurinol.
Introduction
Riloric is a medical drug used in the treatment of gout and certain types of kidney stones. It is used to reduce urate production and reduce levels of serum uric acid. Riloric is also used to treat cancer-related hyperuricemia and tumor lysis syndrome. It is an inhibitor of the enzyme xanthine oxidase, which is responsible for converting hypoxanthine to xanthine and then to uric acid. By limiting the amount of uric acid produced, Riloric helps to lower concentrations of uric acid in the blood.
Uses
Riloric is primarily used for the prevention and treatment of gout and kidney stones. It is also used to reduce the risk of recurrent gout attacks and to treat tumor lysis syndrome, a metabolic complication associated with cancer chemotherapy. Riloric can also be used to prevent uric acid accumulation in the body caused by certain medical conditions, such as certain forms of kidney and bone marrow diseases.
Mechanism of Action
Riloric works by blocking the enzyme xanthine oxidase. This enzyme is responsible for converting hypoxanthine to xanthine and then to uric acid. This process is inhibited by Riloric, which reduces the amount of uric acid produced in the body. By decreasing the amount of uric acid produced, Riloric helps to reduce poor blood flow, inflammation, swelling, and pain, which are common symptoms of gout and other forms of arthritis or joint infection.
How Long Does it Take to Work?
The effects of Riloric can be noticed within 1-2 weeks of starting the treatment. Many patients who take Riloric notice a reduction in pain and discomfort within this time frame, as Riloric is effective in reducing the amount of uric acid in the bloodstream.
Absorption
Riloric is rapidly and almost completely absorbed after oral administration, with plasma concentrations reaching peak levels 1-2 hours after ingestion. The peak plasma concentration is proportional to the dose taken. Riloric is widely distributed throughout the body, with a volume of distribution estimated at 0.5 to 1 L/kg.
Route of Elimination
Riloric is mainly eliminated through the renal route. It is metabolized in the liver by the cytochrome P450 enzyme system. Some of the metabolites are excreted through the bile. Approximately 80% of an oral dose is excreted in the urine as unchanged drug and metabolites.
Dosage
- Adults: The usual dose of Riloric is 200 to 800 mg/day given as a single daily dose or divided and given in 2 to 3 daily doses.
- Children: The dose of Riloric in children is determined by body weight. A normal starting dose for children 1 year of age or older is 5-10 mg/kg/day. The dose may be adjusted in increments of 5-10 mg/kg/day as needed until a satisfactory response is achieved.
- Elderly: The usual dose of Riloric in elderly patients is 200 to 400 mg/day given as a single daily dose or divided and given in 2 daily doses.
Administration
Riloric should be taken orally, usually once daily or as directed by your doctor. It can be taken with or without food. Riloric tablets should not be crushed, broken, or chewed before swallowing.
Side Effects
The most common side effects of Riloric include nausea, vomiting, stomach pain, diarrhea, itching, rash, headache, dizziness, drowsiness, and joint pain. Other less common side effects may include muscle pain, fever, blood in the urine, inflammation of the eyes and liver or renal function test abnormalities. If any of these side effects occur, you should contact your doctor as soon as possible.
Toxicity
Riloric has been associated with rare cases of serious and potentially fatal liver damage, while other toxicities such as rashes, angioedema, and Stevens-Johnson syndrome have been reported.
Precautions
You should not take Riloric if you are allergic to it or any of its components, or if you have a history of liver or kidney disease. Riloric should be used with caution in patients with severe gout, kidney impairment, or diabetes. It should also be avoided in pregnant women unless clearly needed and some caution should be taken in nursing mothers. Additionally, you should inform your doctor if you have any allergies, are taking any other medications, or have any existing medical conditions.
Interactions
Riloric may interact with certain medications, including cholestyramine, thiazide diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), and sulfinpyrazone. These interactions can increase, decrease, or alter the effectiveness of Riloric or other medications. It is important to discuss any medication you are taking with your doctor before starting Riloric.
Disease Interaction
Riloric can interact with certain diseases or medical conditions, increasing, decreasing, or altering its effects. These include gout, kidney impairment, diabetes, hypothyroidism, liver disease, anemia, and hypertension. It is important to discuss any medical condition you have with your doctor before starting Riloric.
Drug Interaction
Riloric can interact with certain drugs, including cholestyramine, thiazide diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), and sulfinpyrazone. These interactions can increase, decrease, or alter the effectiveness of Riloric or other medications. It is important to discuss any medication you are taking with your doctor before starting Riloric.
Food Interactions
Consumption of foods and beverages containing caffeine, alcohol, or sugar can affect the absorption of Riloric. Additionally, certain foods may increase or decrease the effectiveness of Riloric. It is important to discuss any dietary plan you have with your doctor before starting Riloric.
Pregnancy Use
Riloric is classified as pregnancy category D due to its potential to cause harm to the fetus if used during pregnancy. Animal studies have revealed adverse reactions on fetal development when pregnant animals have been treated with Riloric. Therefore, your doctor may not recommend the use of Riloric during pregnancy. Women who are pregnant or breastfeeding must consult with their doctor before taking Riloric.
Lactation Use
Riloric is classified as pregnancy category L3, meaning that it is unlikely to cause harm to nursing infants when used during lactation. However, women who are pregnant or breastfeeding must consult with their doctor before taking Riloric.
Acute Overdose
An overdose of Riloric can cause symptoms such as drowsiness, confusion, dizziness, nausea, seizures, and severe abdominal or back pain. If you or someone you know has taken an overdose of Riloric, seek immediate medical attention. Do not attempt to induce vomiting or take any other action until a medical professional advises you to do so.
Contraindication
Riloric should not be used in patients who are allergic to it or any of its components. Additionally, Riloric should not be used by individuals who have a history of liver or kidney disease, diabetes, or hypothyroidism.
Use Direction
Riloric should be taken orally, usually once daily or as directed by your doctor. Riloric tablets should not be crushed, broken, or chewed before swallowing.
Storage Condition
Riloric should be stored at room temperature in a dark and dry place. The tablets should not be exposed to light, moisture, or extreme temperatures.
Volume of Distribution
The volume of distribution of Riloric is estimated to be 0.5-1 L/kg.
Half Life
The plasma half-life of Riloric is estimated to be 1.9-4.5 hours.
Clearance
The renal clearance of Riloric is approximately 80 mL/min.
Here you find in details version of Riloric
Some Frequently Asked Questions About Riloric
What is Riloric?
Riloric is a form of medication used to help lower the levels of uric acid in the body. It is primarily prescribed to help treat conditions like gout and certain kinds of kidney stones.
Is Riloric safe?
Yes, Riloric is generally considered to be a safe medication when taken as directed. Talk to your doctor if you have any specific questions or concerns about the risks associated with using Riloric.
How long does it take for Riloric to start working?
Most people start to feel the effects of Riloric after about a week of consistent use. Make sure to talk to your doctor about any changes you notice in your condition during this time.
Can I drink alcohol while taking Riloric?
No. You should avoid drinking alcohol while taking Riloric as this can increase the risk of experiencing side effects. Talk to your doctor if you have any specific questions or concerns about drinking and taking Riloric.
Does Riloric cause weight gain?
No. Riloric does not directly cause weight gain. However, some of the side effects of Riloric can include increased appetite, which may lead to weight gain.
Does Riloric affect kidney function?
Riloric may have a slight effect on kidney function in some people. Be sure to talk to your doctor if you have any preexisting kidney problems as Riloric may not be the right medication for you.
What are common side effects of Riloric?
Common side effects of Riloric can include nausea, vomiting, diarrhea, headaches, rash, and dizziness. Talk to your doctor if any of these side effects become worse or if you experience anything else that seems abnormal or concerning.
Can Riloric be used to treat pain?
No. Riloric is primarily prescribed to help lower the levels of uric acid in the body. If you are experiencing pain you should talk to your doctor about medications or other treatments that may be able to help you.
What is the proper dosage for Riloric?
The proper dosage for Riloric depends on your age, weight, and condition. Talk to your doctor about what dose is appropriate for you.
Can Riloric be used for long-term treatment?
Yes. Riloric can be taken for long-term treatment of conditions like gout and certain kinds of kidney stones. Talk to your doctor about whether Riloric is right for your situation.
Does Riloric interact with other medications?
Yes, Riloric can interact with other medications including antibiotics, diuretics, and chemotherapeutic agents. Talk to your doctor about which medications may interact with Riloric and what the potential risks are.
Can I take Riloric while pregnant?
No. Riloric should not be taken while pregnant and should be avoided by anyone who is nursing. Talk to your doctor if you are pregnant, planning to become pregnant, or are nursing.
How often should I take Riloric?
The frequency of taking Riloric will depend on your specific condition and may vary from person to person. Talk to your doctor about what schedule is best for you.
Can I take Riloric with food?
Yes, Riloric can typically be taken with food. Talk to your doctor about any specific instructions you should follow when taking Riloric.
Can Riloric be used to prevent gout?
Yes, Riloric can be used to prevent gout flare-ups by reducing the amount of uric acid in the body. Talk to your doctor to see if Riloric is a good prevention option for you.
What should I do if I miss a dose of Riloric?
If you miss a dose of Riloric, it is important that you take the missed dose as soon as possible. If it is close to the time for the next dose, skip the missed dose and take the next dose at the regular time.
Should I avoid sunlight while taking Riloric?
Yes. Riloric can make your skin more sensitive to sunlight, so you should avoid direct sunlight or use sunscreen when going outdoors. Talk to your doctor about any specific instructions you should follow.
Are there any alternative treatments for gout?
Yes, there are alternative treatments for gout. Treatment options may include dietary changes, over-the-counter medications like ibuprofen, or lifestyle changes. Talk to your doctor about which options may be right for you.
Can Riloric cause hair loss?
No, Riloric is not known to cause hair loss. However, some people may experience hair loss due to the condition being treated with Riloric.
What is the maximum daily dose of Riloric?
The maximum daily dosage of Riloric will depend on your specific condition and any other medicines you are taking. Talk to your doctor about what dosage is right for you.
Are there any tests I should take before starting Riloric?
Yes, your doctor may want to run several tests before starting Riloric, including blood tests to check your kidney and liver function, as well as urine tests to check for any existing uric acid levels. Talk to your doctor about any specific tests you should take.
Can Riloric be used to treat kidney stones?
Yes, Riloric can be used to help dissolve certain types of kidney stones. Talk to your doctor about whether Riloric is right for you.
Will I need to take Riloric forever?
No, you may not need to take Riloric forever. The length of your treatment will depend on your condition. Talk to your doctor about how long you should continue taking Riloric.
Does Riloric cause headaches?
Yes, headaches can be a common side effect of Riloric. Talk to your doctor if you experience any frequent or severe headaches while taking Riloric.
What should I do if I overdose on Riloric?
If you think you have taken too much Riloric, call 911 or your local poison control center immediately. You should also contact your doctor as soon as possible.
Can I take Riloric if I have diabetes?
Yes, Riloric can be taken if you have diabetes. However, you should talk to your doctor about potential interactions between Riloric and your diabetic medication.
Is Riloric a narcotic?
No, Riloric is not a narcotic. It is a form of medication used to help lower the levels of uric acid in the body.
Is Riloric a steroid?
No, Riloric is not a steroid. It is a form of medication used to help lower the levels of uric acid in the body.
Can I take Riloric with non-steroidal anti-inflammatory drugs (NSAIDs)?
Yes, Riloric can be taken with other medications, including non-steroidal anti-inflammatory drugs (NSAIDs). Talk to your doctor if you are taking any other medications and are considering taking Riloric.
Can I take Riloric if I have high blood pressure?
Yes, Riloric can be taken if you have high blood pressure. However, it is important to talk to your doctor about potential interactions between Riloric and any other medications you are taking.
What should I watch out for while taking Riloric?
Make sure to talk to your doctor if any new or concerning symptoms arise while taking Riloric. Common side effects to watch out for include nausea, vomiting, diarrhea, headaches, rash, and dizziness.
Can Riloric cause stomach problems?
Yes, Riloric can cause stomach problems in some people. Common stomach problems include nausea, vomiting, and diarrhea. Talk to your doctor if you experience any of these symptoms while taking Riloric.
Can I take Riloric if I'm on dialysis?
Yes, Riloric can be taken while on dialysis. Make sure to talk to your doctor about which dose is right for you.
Does Riloric have any interactions with herbal medications?
Yes, Riloric may interact with certain herbal medications like turmeric, ginger, and ginkgo biloba. Talk to your doctor about which herbs you should avoid while taking Riloric.
Can I take Riloric if I have an allergy to sulfa drugs?
No, it is not recommended that Riloric be taken if you have an allergy to sulfa drugs. Make sure to tell your doctor about any existing allergies you have before taking Riloric.
Are there any restrictions on activities while taking Riloric?
Yes, you should avoid activities that could cause skin irritation while taking Riloric, such as sunbathing, hot showers, and long baths. Talk to your doctor if you have any specific activities that you are unsure about.
Can I take Riloric if I'm breastfeeding?
No, allopurinol should not be taken while breastfeeding. Talk to your doctor if you are breastfeeding and considering taking Riloric.
What time of day should I take Riloric?
The best time to take Riloric depends on your doctor's instructions. It may be taken once daily or several times throughout the day. Talk to your doctor about what time is best for you.
Can Riloric cause liver damage?
Yes, Riloric can cause liver damage, although it is rare. Make sure to talk to your doctor if you experience any symptoms of liver damage, such as nausea, vomiting, yellowing of the skin or eyes, or dark urine.
Can Riloric cause a rash?
Yes, Riloric can cause a rash in some people. If you develop a rash while taking Riloric, make sure to talk to your doctor as soon as possible.
Can Riloric be used to treat cancer?
No, Riloric is not used to treat cancer. Talk to your doctor about which treatments may be right for you.
Can Riloric be used to treat an infection?
No, Riloric is not used to treat infections. It is primarily prescribed to help lower the levels of uric acid in the body. Talk to your doctor about which medications or treatments may be right for you.