Recombinant
Recombinant Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Recombinant is a brand name. Its generic name is Alteplase.
Recombinant
Recombinant is a drug used to treat a blockage in the blood vessels which is referred to as thrombosis. Thrombosis can result in a variety of conditions such as stroke, heart attack, and other life-threatening and disabling conditions. Recombinant works to dissolve the clot which can allow blood to flow more freely, mitigating the damaging affects of thrombosis.
Uses For Recombinant
Recombinant can be used to treat certain conditions that are caused by thrombosis, or a blood clot that blocks the blood flow. This type of condition can include heart attacks, pulmonary embolism, ischemic strokes, deep vein thrombosis, and others. Recombinant is given intravenously (IV) or into the coronary artery system. It helps to dissolve the clot, which can allow improved blood flow to the affected area.
Mechanism of Action
Recombinant is a tissue-type plasminogen activator (tPA). This is an enzyme that helps to break down fibrin, a protein that is a major component of all clotting activities. By breaking down the fibrin, Recombinant can help blood to flow more freely, by breaking down the clot or reducing its size. Recombinant has a very short action time, with it being typically completely effective within 4-5 hours.
How Long Does it Take To Work?
Recombinant has a very short action time, with it being typically completely effective within 4-5 hours. Recombinant will typically start to work within 30 minutes, with the most effective time period being 3-4 hours after administration. After the injection, the effects can be monitored by an ultrasound or other imaging techniques.
Absorption
Recombinant is mostly administered intravenously (IV) or into the coronary artery system. It is slowly absorbed and distributed to the affected area. Recombinant is mainly metabolized by the liver, and the elimination half-life is approximately 4.5 hours.
Route of Elimination
Recombinant is eliminated by the liver through various metabolic pathways. Most of the drug is eliminated through urine. The elimination half-life is approximately 4.5 hours.
Dosage
The dosage of Recombinant will depend on the indication and the severity of the condition. The recommended dose is 10-15 mg of Recombinant for 10 minutes, followed by an additional 10 mg for 30 minutes. The maximum total dose should not exceed 100mg. A lower dose may be indicated for patients with renal dysfunction.
Administration
Recombinant is typically administered intravenously (IV) or into the coronary artery system. It is typically administered over a period of time, with an initial bolus infusion of 10-15 mg of alteplase, followed by an additional 10 mg over the next 30 minutes.
Side Effects
Common side effects of Recombinant include headache, nausea, vomiting, abdominal pain, fatigue, shortness of breath, dizziness, and weakness. Rare side effects include rash, hypertension, chest pain, hematoma, and thrombolysis.
Toxicity
Recombinant is generally well tolerated when used within the recommended dose range. It is important to follow the prescribed dosing guidelines and to avoid using higher doses than recommended. High doses of Recombinant can increase the risk of bleeding.
Precautions
Patients receiving Recombinant should inform their doctor of any known medical conditions or allergies they may have, any medications they are taking, and if they are pregnant or breastfeeding. Recombinant should be used with caution in patients with a history of bleeding, blood coagulation disorders, head trauma, stroke, brain tumor, or recent surgery. Recombinant should also be used with caution in patients with renal impairment.
Interaction
Recombinant should not be used in combination with other anticoagulants. It has the potential to interact with other medications such as aspirin, heparin, warfarin, and nonsteroidal anti-inflammatory drugs (NSAIDs). Patients should speak with their doctor about all medications and supplements they are taking.
Disease Interaction
Recombinant should not be used in patients with active bleeding or a known predisposition to bleeding. Recombinant should also not be used in patients with a history of stroke, brain tumor, head trauma, or recent surgery. It should also be used with caution in patients with renal impairment.
Drug Interactions
Recombinant should not be used in combination with other anticoagulants. It has the potential to interact with other medications such as aspirin, heparin, warfarin, and nonsteroidal anti-inflammatory drugs (NSAIDs). Patients should speak with their doctor about all medications and supplements they are taking.
Food Interactions
Recombinant should be taken on an empty stomach. Alcohol and certain foods (such as dairy products) should be avoided while taking Recombinant. Patients should speak with their doctor about any specific dietary considerations they may have.
Pregnancy Use
Recombinant is not recommended for use in pregnant women. Due to the potential risks associated with clotting, pregnant women should speak with their doctor about alternative treatments.
Lactation Use
Recombinant is not recommended for use in lactating women. The risks of using Recombinant in lactating women have not been established.
Acute Overdose
A single dose of Recombinant in excess of 100 mg can cause severe bleeding. If any signs or symptoms of overdose or bleeding occur, seek medical attention immediately.
Contraindications
Recombinant should not be used in patients with active bleeding or a known predisposition to bleeding. It should also not be used in patients with a history of stroke, brain tumor, head trauma, or recent surgery. It should also be used with caution in patients with renal impairment.
Use Directions
Recombinant should be administered intravenously or into the coronary artery system. The recommended dose is 10-15 mg of Recombinant for 10 minutes, followed by an additional 10 mg for 30 minutes. The maximum total dose should not exceed 100mg. Patients should always follow the instructions of their doctor or pharmacist.
Storage Condition
Recombinant should be stored in its original packaging at a temperature between 36°F and 77°F. It should be kept away from heat, light, and moisture.
Volume of Distribution
Recombinant has a low volume of distribution, which means it is quickly distributed to the affected area. It is mainly metabolized by the liver, and the elimination half-life is approximately 4.5 hours.
Half Life
The half life of Recombinant is approximately 4.5 hours. This means that, after 4.5 hours, half of the original dose is still present in the body.
Clearance
Recombinant is mostly eliminated through metabolic pathways within the liver. The clearance rate of Recombinant is not well-defined.
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