Reboxetina
Reboxetina Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Reboxetina is a brand name. Its generic name is Reboxetine.
Introduction
Reboxetina (marketed as Edronax, Norebox, Solvex, Prolift and Pexep) is a norepinephrine reuptake inhibitor (NRI) used in the treatment of clinical depression. It is also used to treat attention deficit hyperactivity disorder (ADHD) and to improve physical and emotional symptoms of fibromyalgia. Reboxetina is a cyclopentoxy-benzazepine drug which is related to the class of phenyltropanes.
Uses for
Reboxetina is used as an antidepressant by reducing the symptoms of depression such as feelings of sadness, loss of interest, and depression. It also helps improve concentration, energy and motivation. Reboxetina is also used to treat attention deficit hyperactivity disorder (ADHD) by improving attention and decreasing impulsivity and hyperactivity. It is also used to improve physical and emotional symptoms of fibromyalgia.
Mechanism of Action
Reboxetina selectively inhibits the reuptake of norepinephrine, the neurotransmitter that helps maintain normal moods. The effectiveness of the drug is thought to be due to its ability to increase the concentration of norepinephrine in the brain, thus improving the communication between neurons.
How Long Does it Take to Work?
Reboxetina generally starts to work within 2–4 weeks of beginning treatment, and its effects may continue to improve over a period of several weeks. It may take up to 8 weeks for its maximum effect to be reached.
Absorption
Reboxetina is rapidly and completely absorbed after oral administration. It has an absolute bioavailability of 90% and is subject to first-pass metabolism.
Route of Elimination
Reboxetina is primarily metabolized to its active metabolite desmethylreboxetine by the cytochrome P450 (CYP) isoenzymes CYP2D6 and CYP3A4. Both metabolites are also subject to further metabolism. Metabolites are mainly eliminated through the urine and feces.
Dosage
The recommended starting dose of Reboxetina for adults is 8mg per day, which can be adjusted up to a maximum of 16mg daily depending on the patient’s response to the drug. For children and adolescents aged 7 to 18 years, the recommended starting dose is 4mg per day which can be increased up to 8mg daily.
Administration
Reboxetina is available as tablets and should be taken in the morning. It should be taken with a full glass of water and should not be split, crushed, or chewed. It is important to take Reboxetina at the same time every day to maintain a steady level in the body.
Side Effect
Reboxetina is generally well tolerated. The most common side effects associated with the use of Reboxetina are sleeplessness, dry mouth, nausea, constipation, reduced appetite, headache,increased sweating and dizziness.
Toxicity
The toxicity of Reboxetina is low, and cases of overdose have been reported to result in very mild symptoms. Symptoms of overdose may include nausea, vomiting, dry mouth, agitation, sweating and difficulty sleeping.
Precaution
Reboxetina should be used with caution in patients with liver and kidney impairment, cardiovascular disorders and psychiatric disorders. It should not be administered to patients with narrow-angle glaucoma, a history of convulsion or a cardiac arrhythmia.
Interaction
Reboxetina may interact with other medications including monoamine oxidase inhibitors, nonsteroidal anti-inflammatory drugs, opioid analgesics, antipsychotics and some antibiotics. Thus, it is important to tell the doctor about all the medicines taken before beginning treatment with Reboxetina.
Disease Interaction
Reboxetina may interact with other diseases such as narrow-angle glaucoma, convulsion, arrhythmia, infantile hypertension, bipolar disorder, and depression. It is important to inform the doctor of all medical conditions before beginning treatment with Reboxetina.
Drug Interaction
Drug interactions can occur when taking Reboxetina with certain medications such as antidepressant, antipsychotics, nonsteroidal anti-inflammatory drugs, opioid analgesics and some antibiotics. It is important to inform the doctor of all the medications taken before beginning treatment with Reboxetina.
Food Interactions
Food interactions can occur when taking Reboxetina with certain foods such as grapefruit, foods high in tyramine and red wine. It is important to inform the doctor of all the dietary restrictions before beginning treatment.
Pregnancy Use
Reboxetina is not recommended for use in pregnant women. It is in the category C pregnancy risk and may increase the risk of birth defects. Therefore, it should not be taken during pregnancy unless it is absolutely needed.
Lactation Use
Reboxetina is not recommended for use in nursing mothers. It passes into breast milk and may harm the baby. Therefore, it should not be taken by nursing mothers unless it is absolutely necessary.
Acute Overdose
Symptoms of an acute overdose with Reboxetina include nausea, vomiting, dry mouth, agitation, sweating and difficulty sleeping. It is important to seek immediate medical attention in case of an overdose with Reboxetina.
Contraindication
Reboxetina is contraindicated in patients with a history of narrow angle glaucoma, convulsion, arrhythmia, infantile hypertension, bipolar disorder, and depression.
Use Direction
Reboxetina should be taken exactly as directed by the doctor. The tablets should be swallowed whole with a full glass of water. It is important to take Reboxetina at the same time every day to maintain a steady level in the body.
Storage Condition
Reboxetina should be stored at room temperature. Keep away from direct light and heat. Do not store in the bathroom, and keep out of the reach of children.
Volume of Distribution
The volume of distribution of Reboxetina is 2.7-3.2L/kg.
Half Life
The half-life of Reboxetina is 99 hours.
Clearance
The clearance of Reboxetina is 175mL/min/kg.
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