Quinalbarbitone
Quinalbarbitone Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Quinalbarbitone is a brand name. Its generic name is Secobarbital.
Quinalbarbitone Introduction
Quinalbarbitone, or Quinalbarbitone sodium, is a sedative-hypnotic barbiturate type medication used primarily to treat insomnia, anxiety, and seizures. It was initially approved by the FDA in 1957. Quinalbarbitone has been referred to under a wide variety of trade names, including Seconal and Tuinal, and is commonly prescribed in combination with other medications such as benzodiazepines.
Uses for Quinalbarbitone
Quinalbarbitone is used primarily to treat insomnia and as a sedative in combination with other medications such as benzodiazepines. It can also be used to treat anxiety, seizures, and other medical conditions. It is also sometimes used as part of an anesthetic preparation.
Mechanism of Action
The mechanism of action of Quinalbarbitone is not fully understood. It is known to act on the gamma-aminobutyric acid (GABA) receptor in the brain, as well as bind to a variety of other receptors, such as the benzodiazepine receptor, which is involved in the sedative and anxiolytic effects of Quinalbarbitone. Other mechanisms, such as the binding of Quinalbarbitone to other receptors, may also be involved.
How Long Does it Take to Work?
Quinalbarbitone generally begins to take effect within 20 to 30 minutes after ingestion, although it can sometimes take up to an hour to take effect. It can remain effective for up to 6 hours depending on the formulation and dose.
Absorption
Quinalbarbitone is well absorbed by the gastrointestinal tract. The intraoral bioavailability of Quinalbarbitone is approximately 90%.
Route of Elimination
Quinalbarbitone is largely eliminated through the kidneys. Approximately 90% is excreted unchanged by the kidneys, while the remainder is metabolized in the liver. Most of the metabolites are eliminated in the urine.
Dosage
Quinalbarbitone is available in several different dosage forms, including tablets, capsules, oral suspension, and injectable solution. The recommended starting dose for adults for the treatment of insomnia is usually 100-200mg taken at bedtime. For anxiety and seizure disorders, the dose may vary depending on the severity of the condition, but typically ranges from 100-400mg per day.
Administration
Quinalbarbitone is usually taken orally. It can also be administered intravenously in the form of an injectable solution. It should be taken with or after a light meal.
Side Effects
The most common side effects of Quinalbarbitone include drowsiness, dizziness, slurred speech, blurred vision, confusion, constipation, dry mouth, blurred vision, nausea, and vomiting. More serious side effects include respiratory depression, low blood pressure, difficulty breathing, and seizures.
Toxicity
Accidental or intentional overdose with Quinalbarbitone can be fatal due to the risk of respiratory depression. Signs and symptoms of toxicity include hypotension, excitement, delusions, coma, and death.
Precautions
Before taking Quinalbarbitone, it is important to tell your doctor about any other medications you are taking and any allergies you have. Quinalbarbitone may cause drowsiness and impair your ability to drive or operate machinery. It should also not be taken with alcohol, as this can increase the risk of side effects. Patients with kidney, liver, or lung disease should use caution when taking Quinalbarbitone, as these conditions can increase the risk of side effects.
Interactions
Quinalbarbitone can interact with a number of medications, including alcohol, sedatives, antidepressants, antipsychotics, anticonvulsants, muscle relaxants, and narcotic pain relievers. It can also interact with certain herbal supplements. It is important to tell your doctor about all medications and supplements you are taking before taking Quinalbarbitone.
Disease Interactions
Patients with kidney, liver, or lung disease should use caution when taking Quinalbarbitone, as these conditions can increase the risk of side effects. Patients with a history of depression or suicidal thoughts should also use caution when taking Quinalbarbitone, as it can worsen these conditions. Patients with sleep apnea should not take Quinalbarbitone.
Drug Interactions
Quinalbarbitone can interact with a number of medications, including alcohol, sedatives, antidepressants, antipsychotics, anticonvulsants, muscle relaxants, and narcotic pain relievers. It is important to tell your doctor about all medications and supplements you are taking before taking Quinalbarbitone.
Food Interactions
Quinalbarbitone should be taken after a light meal in order to reduce the risk of gastrointestinal upset. Alcohol should be avoided while taking Quinalbarbitone, as alcohol can increase the risk of side effects.
Pregnancy Use
Quinalbarbitone is not recommended for use in pregnant women due to the risk of birth defects, although it may be used if the potential benefits outweigh the risks. If you are pregnant, it is important to tell your doctor before taking Quinalbarbitone.
Lactation Use
Quinalbarbitone is not recommended for use while breastfeeding as it can pass into breast milk and cause harm to the baby. If you are breastfeeding, it is important to tell your doctor before taking Quinalbarbitone.
Acute Overdose
Signs and symptoms of an acute overdose of Quinalbarbitone include drowsiness, confusion, hypotension, and shallow breathing. Coma and death can occur due to respiratory depression. Immediate medical attention is required for an overdose.
Contraindications
Quinalbarbitone is contraindicated in patients with known hypersensitivity to barbiturates, as well as patients with a history of drug abuse or addiction. It should also not be used in patients with sleep apnea or chronic respiratory failure.
Use Directions
Quinalbarbitone should be taken as directed by your doctor. The dose and frequency of Quinalbarbitone can vary depending on the indication being treated, but typically ranges from 100-400mg per day taken at bedtime. It should be taken with or after a light meal.
Storage Conditions
Quinalbarbitone should be stored at room temperature in a dry, dark place away from direct sunlight. It should also be kept out of reach of children and pets.
Volume of Distribution
The volume of distribution of Quinalbarbitone is 0.5 L/kg.
Half Life
The half-life of Quinalbarbitone is 14-60 hours, depending on the formulation.
Clearance
The clearance of Quinalbarbitone is approximately 0.1 ml/min/kg.
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