Prostaglandin E2
Prostaglandin E2 Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Prostaglandin E2 is a brand name. Its generic name is Dinoprostone.
Prostaglandin E2
Prostaglandin E2 is a naturally occurring hormone-like substance that is used to help induce labor or complete an abortion. It is also known as PGE2 or prostaglandin E2.
Uses
Prostaglandin E2 is used to induce labor in pregnant women who can safely experience childbirth, and to ripen the cervix of pregnant women who require induction of labor. It is also used to complete a medical abortion.
Mechanism of Action
Prostaglandin E2 stimulates the uterus to contract and is also thought to act in various other ways to prepare the uterus for labor.
How Long Does It Take To Work?
Prostaglandin E2 usually takes between 30 minutes and 6 hours to begin working. Once dinoprostone is administered, the patient should be monitored closely for changes in contractions.
Absorption
Prostaglandin E2 is rapidly absorbed when administered via vaginal suppository or gel.
Route of Elimination
Prostaglandin E2 is rapidly metabolized and eliminated through the kidneys when administered vaginally, but can also be eliminated via other routes.
Dosage
When dinoprostone is used to induce labor, the recommended dosage is a single 0.5 mg to 2 mg suppository or 3mg to 5 mg gel, depending on the patient’s age and medical history. When used to complete a medical abortion, the dose is 0.5 mg.
Administration
Prostaglandin E2 is administered intravaginally via a suppository or gel.
Side Effect
The most common side effects associated with the use of dinoprostone include nausea, vomiting, diarrhea, and increased contractions.
Toxicity
The safety of dinoprostone has not been evaluated in humans. It should only be used under medical supervision and appropriate dosing must be observed. Overdoses are possible with dinoprostone.
Precaution
It is important to use caution when administering dinoprostone. It is essential that the patient is monitored closely for signs of labor or other side effects. Those with allergies to any form of prostaglandin or with a history of medical complications should avoid the use of dinoprostone.
Interaction
Prostaglandin E2 may interact with other medications, including anticoagulants, blood thinners, and anti-inflammatory drugs.
Disease Interaction
Prostaglandin E2 can worsen the symptoms of asthma, heart failure, and diabetes, and should not be used in those with such preexisting conditions.
Drug Interaction
Prostaglandin E2 can interact negatively with other medications, including anticoagulants, blood thinners, and anti-inflammatory drugs.
Food Interactions
Prostaglandin E2 should not be taken with certain foods that can swell in the stomach or increase absorption rate. Examples include dairy products, high-fat meals, and alcoholic beverages.
Pregnancy Use
Prostaglandin E2 is not recommended for use in pregnant women due to potential risk to the fetus.
Lactation Use
Prostaglandin E2 is not recommended for use in lactating women due to potential risk to the infant.
Acute Overdose
Symptoms of acute overdose include nausea, vomiting, abdominal discomfort, and increased abdominal cramps. Patients experiencing serious side effects should seek immediate medical attention.
Contraindications
Prostaglandin E2 is contraindicated in pregnant women, those with a history of abortion or miscarriage, and those with a history of any allergy to a prostaglandin.
Use Directions
When using dinoprostone, be sure to closely follow the directions provided by your doctor or pharmacist.
Storage Condition
Prostaglandin E2 should be stored at room temperature and away from direct sunlight.
Volume of Distribution
Prostaglandin E2 is rapidly absorbed when administered intravenously and has an estimated volume of distribution of 0.29 L/kg.
Half Life
The elimination half-life of dinoprostone is estimated to be 6 to 10 minutes when administered intravenously.
Clearance
The clearance of dinoprostone is estimated to be 0.13 L/kg/min when administered intravenously.
Here you find in details version of Prostaglandin E2
Some Frequently Asked Questions About Prostaglandin E2
What is Prostaglandin E2?
Prostaglandin E2 is a synthetic form of prostaglandin E2, a naturally occurring hormone involved in beginning the process of labor in pregnant women.
When is Prostaglandin E2 usually used?
Prostaglandin E2 is usually used to induce or augment labor when a pregnant woman's obstetrician determines it is medically necessary.
What are the potential risks related with Prostaglandin E2?
The potential risks associated with Prostaglandin E2 include maternal adverse events such as nausea, vomiting, diarrhea, uterine hyperstimulation, and fetal adverse events such as fetal heart rate abnormalities.
What kind of delivery is Prostaglandin E2 typically used for?
Prostaglandin E2 is typically used for vaginal delivery, but can also be used for Cesarean section deliveries.
What is the usual dosage for Prostaglandin E2?
The usual dosage for Prostaglandin E2 is 0.5 mg (measured in milligrams) every 6-8 hours.
How does Prostaglandin E2 work?
Prostaglandin E2 works by stimulating the smooth muscle tissue in the uterus, which encourages contractions that can help to open (dilate) the cervix.
How is Prostaglandin E2 used?
Prostaglandin E2 is usually administered as a vaginal gel or a tablet that is placed in the vagina. It can also be injected directly into the uterus.
What are the side effects associated with the use of Prostaglandin E2?
The side effects associated with the use of Prostaglandin E2 include nausea, vomiting, diarrhea, uterine hyperstimulation, and fetal heart rate abnormalities.
How long does it take for Prostaglandin E2 to take effect?
It typically takes around 30 minutes for Prostaglandin E2 to take effect.
What is the maximum dose of Prostaglandin E2 that can be used?
The maximum safe dose of Prostaglandin E2 is 10 mg.
Can Prostaglandin E2 be used for a preterm labor?
Prostaglandin E2 can be used for a preterm labor but the use of Prostaglandin E2 in preterm labor is not currently recommended by the American College of Obstetricians and Gynecologists (ACOG).
Can Prostaglandin E2 be used to induce labor?
Yes, Prostaglandin E2 is often used to induce labor when a pregnant woman's obstetrician determines it is medically necessary.
How quickly can Prostaglandin E2 be administered?
Prostaglandin E2 can be administered as quickly as every 6-8 hours depending on the doctor's discretion.
Is Prostaglandin E2 safe for pregnant women?
Yes, Prostaglandin E2 is generally considered safe for pregnant women when used as prescribed.
How long does it typically take for Prostaglandin E2 to be effective?
It typically takes around 30 minutes for Prostaglandin E2 to be effective.
What are the effects of Prostaglandin E2 on the fetus?
The effects of Prostaglandin E2 on the fetus can include fetal heart rate abnormalities.
What are the common side effects of Prostaglandin E2?
The common side effects of Prostaglandin E2 include nausea, vomiting, diarrhea, uterine hyperstimulation, and fetal heart rate abnormalities.
What happens if Prostaglandin E2 is not effective in inducing labor?
If Prostaglandin E2 is not effective in inducing labor, doctors may recommend other methods of induction such as oxytocin infusion or the use of antibiotics.
How long after Prostaglandin E2 is administered does labor usually begin?
Labor usually begins within 24 hours of Prostaglandin E2 administration.
Does Prostaglandin E2 cause any long-term side effects?
There have been no reported long-term side effects associated with the use of Prostaglandin E2.
Is Prostaglandin E2 effective in all cases?
No, Prostaglandin E2 may not be effective in some cases, such as when the cervix is not sufficiently dilated or when the placenta is positioned over the cervix.
Can Prostaglandin E2 be used to induce labor at home?
No, Prostaglandin E2 should not be used to induce labor at home, as it is a prescription drug and should only be administered in a medical setting.
Does Prostaglandin E2 increase the risk of complications for mother and baby?
Prostaglandin E2 increases the risk of certain maternal adverse events, such as nausea, vomiting, diarrhea, and uterine hyperstimulation, as well as fetal adverse events, such as fetal heart rate abnormalities.
Can Prostaglandin E2 be used for c-sections?
Yes, Prostaglandin E2 can be used for both vaginal deliveries and Cesarean section (c-section) deliveries.
What are the signs of Prostaglandin E2 working properly?
The signs of Prostaglandin E2 working properly include increased uterine activity, increased cervical dilation, and increased descent of the fetus.
What happens if Prostaglandin E2 is discontinued?
If Prostaglandin E2 is discontinued, the labor process will stop and further medical intervention may be necessary.
What should be done if Prostaglandin E2 does not produce effective labor contractions?
If Prostaglandin E2 does not produce effective labor contractions, then doctors may recommend administration of oxytocin infusion or the use of antibiotics.
Can Prostaglandin E2 be used for multiple gestations?
Yes, Prostaglandin E2 can be used for multiple gestations.
Can Prostaglandin E2 cause fetal distress?
Yes, the use of Prostaglandin E2 can cause fetal distress, which is characterized by fetal heart rate abnormalities.
What should be done if there is excessive uterine activity after the use of Prostaglandin E2?
If there is excessive uterine activity after the use of Prostaglandin E2, the dose should be immediately reduced and medical attention should be sought.
Can Prostaglandin E2 be used to initiate labor in an elective cesarean delivery?
Yes, Prostaglandin E2 can be used to initiate labor prior to elective cesarean sections.
Can Prostaglandin E2 be used to shorten labor?
Yes, Prostaglandin E2 can be used to shorten labour.
What are the contraindications for the use of Prostaglandin E2?
The contraindications for the use of Prostaglandin E2 include, but are not limited to placental previa, previous cesarean section or uterine surgery, an intrauterine pregnancy with an unknown location, fetal macrosomia, and umbilical cord presentation.
What is the recommended monitoring frequency during Prostaglandin E2 administration?
It is recommended that the fetal heart rate be monitored continuously while administering Prostaglandin E2.
Can Prostaglandin E2 be used for painful labor?
Yes, Prostaglandin E2 can be used to induce labor in order to reduce the painful contractions associated with labor.
How can Prostaglandin E2 be administered?
Prostaglandin E2 is typically administered as a vaginal gel or a tablet that is placed in the vagina. It can also be injected directly into the uterus.
What are the side effects of Prostaglandin E2 on the mother?
The side effects of Prostaglandin E2 on the mother include nausea, vomiting, diarrhea, and uterine hyperstimulation.
Does the use of Prostaglandin E2 increase the risk of infection?
Yes, the use of Prostaglandin E2 can increase the risk of infection if used for an induction/augmentation process, as Prostaglandin E2 can contribute to prolonged labor.
Can Prostaglandin E2 be used with oxytocin?
Yes, Prostaglandin E2 can be used in combination with oxytocin when medically necessary.
What should be done if fetal distress is detected during the use of Prostaglandin E2?
If fetal distress is detected during the use of Prostaglandin E2, the dose should be reduced and medical attention should be sought.
What are the alternatives to the use of Prostaglandin E2?
Alternatives to the use of Prostaglandin E2 include the use of oxytocin, antibiotics, and the insertion of a Foley catheter.