Primalex
Primalex Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Primalex is a brand name. Its generic name is Primaquine.
Introduction
Primalex is an antimalarial medication used to treat and prevent certain types of malaria. It is also used as a prophylaxis, which is used to prevent the further spread of malaria after initial treatment. Primalex belongs to a group of antimalarials called 8-amino-quinolines.Uses For
Primalex is used to treat and prevent certain types of malaria caused by Plasmodium falciparum and Plasmodium vivax. It is also used as a prophylaxis (preventive medication) against further accusations of malaria in travelers in areas that are infected with Plasmodium vivax and Plasmodium falciparum. Primalex should not be used in children under 8 years old.Mechanism Of Action
Primalex works by interfering with two essential proteins involved in the synthesis of DNA in the malaria parasite. It inhibits the enzyme dihydrofolate reductase and interferes with the electron transport system, both of which are essential for the parasite to survive. Primalex also has a role in preventing the transmission of the malaria parasite to uninfected mosquito vectors.How Long Does It Take To Work?
Primalex usually takes effect within 1-2 hours of ingestion. The effects of Primalex can last up to 48 hours, so it is important to take the medication as prescribed by a physician.Absorption
Primalex is absorbed quickly and completely from the gastrointestinal tract. It has an apparent volume of distribution of 1.31 L/kg and an apparent bioavailability of 42%.Route Of Elimination
Primalex is eliminated primarily by the kidneys. It has an elimination half-life of 23 hours.Dosage
The recommended dosage for Primalex depends on the condition being treated. For prophylaxis, the usual dosage is 15mg orally once daily for 7 days. For treatment of acute malaria, the usual dosage is 15mg orally once daily for 14 days. It is important to take Primalex exactly as prescribed by a physician.Administration
Primalex should be taken with food or a full glass of water. It should be taken at the same time each day to maintain an even level of medication in the bloodstream.Side Effects
The most common side effects of Primalex include nausea, vomiting, headache, dizziness, loss of appetite, hair loss, hepatitis, rash, and anemia.Toxicity
The toxic effects of Primalex include changes in behavior, disorientation, difficulty breathing, and seizures.Precautions
Before taking Primalex, it is important to inform your physician if you have liver or kidney disease, blood disorders, glucose-6-phosphate dehydrogenase (G6PD) deficiency, or any allergies.Interactions
Primalex can interact with other drugs, including antacids, certain antibiotics, and nonsteroidal anti-inflammatory drugs (NSAIDs).Disease Interactions
Primalex can worsen certain diseases, including cancer, diabetes, anemia, and liver or kidney disease.Drug Interactions
Primalex can interact with certain drugs, including antacids, certain antibiotics, and nonsteroidal anti-inflammatory drugs (NSAIDs).Food Interactions
It is important to take Primalex with food to reduce the risk of interactions.Pregnancy use
Primalex should not be used in pregnant women, as it may cause serious birth defects.Lactationuse
Primalex should not be used while breastfeeding as it may be passed to the infant through breast milk.Acute Overdose
The symptoms of an acute overdose may include severe abdominal pain, nausea, vomiting, seizures, and difficulty breathing. If you suspect an overdose, contact your local poison control center or emergency room immediately.Contraindication
Primalex should not be used in people with certain conditions, including porphyria, G6PD deficiency, severe anemia, and hemolytic anemia.Use Direction
Primalex should be taken as prescribed by a physician. Do not take more or less than the recommended amount.Storage Condition
Primalex should be stored in a cool, dry place, at room temperature. Keep out of reach of children and pets.Volume Of Distribution
Primalex has an apparent volume of distribution of 1.31 L/kg.Half Life
Primalex has an elimination half-life of 23 hours.Clearance
Primalex is eliminated primarily by the kidneys.Here you find in details version of Primalex
Some Frequently Asked Questions About Primalex
What is Primalex?
Primalex is an antimalarial medication used to treat and prevent malaria infection.
How does Primalex work?
Primalex works by killing the malaria parasites in the liver. It also prevents the parasites from multiplying and spreading.
What is the active ingredient in Primalex?
The active ingredient in Primalex is primaquine phosphate.
How long does it take for Primalex to work?
Primalex typically begins to work within 24 hours of taking the medication.
What are the side effects of Primalex?
Typical side effects of Primalex include headache, nausea, dizziness, vomiting, loss of appetite, and abdominal pain.
Is Primalex safe to take during pregnancy?
Primalex should not be used during pregnancy, as it can cause harm to the unborn baby.
Is Primalex safe for children?
Primalex is generally not recommended for use in children under the age of 16.
Does Primalex interact with other medications?
Yes, Primalex can interact with other medications, including antacids, antibiotics, antivirals, and nonsteroidal anti-inflammatory drugs (NSAIDs).
What is the recommended dosage of Primalex?
The recommended dosage of Primalex is 0.5-1 tablet per day for adults and 0.25-0.5 tablet per day for children aged 16 and over.
What is the difference between Primalex and chloroquine?
Primalex is an antimalarial medication used to treat and prevent malaria infections, while chloroquine is an antimalarial medication used to treat and prevent malaria infections and also reduce inflammation in some autoimmune diseases.
Does Primalex need to be taken with food?
It is recommended to take Primalex with food to reduce the risk of stomach upset.
What should I do if I miss a dose of Primalex?
If you miss a dose of Primalex, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and take your next dose at the regular time.
How long should I take Primalex?
The length of time that Primalex should be taken depends on your individual medical condition. Your doctor will advise you on how long to take the medication.
Can I drink alcohol while taking Primalex?
It is not recommended to drink alcohol while taking Primalex, as it may increase the risk of side effects.
What is the generic name for Primalex?
The generic name for Primalex is primaquine phosphate.
Is Primalex an antibiotic?
No, Primalex is not an antibiotic; it is an antimalarial medication.
Can I buy Primalex over the counter?
No, Primalex is a prescription-only medication and cannot be bought over the counter.
Can Primalex be used to treat other conditions?
No, Primalex is only used to treat and prevent malaria infection.
What is the price of Primalex?
The price of Primalex varies depending on the manufacturer and dosage. Your pharmacy can provide you with the most up-to-date pricing information.
Can Primalex cause liver damage?
Yes, Primalex can cause liver damage in some individuals. If you have any liver problems, speak to your doctor before taking Primalex.
Does Primalex cause drowsiness?
Yes, Primalex can cause drowsiness in some individuals. If you experience drowsiness, do not drive or operate machinery.
Does Primalex interact with birth control?
Yes, Primalex can interact with birth control. It is recommended to use another form of birth control while taking Primalex.
Does Primalex cause diarrhea?
Yes, Primalex can cause diarrhea in some individuals.
Is Primalex used to treat malaria?
Yes, Primalex is used to treat and prevent malaria infection.
Does Primalex cause weight gain?
No, Primalex does not typically cause weight gain.
Can I take Primalex with other medications?
It is important to tell your doctor about any other medications you are taking before taking Primalex, as some medications can interact with Primalex.
Will Primalex work against all strands of malaria?
Primalex has been shown to be effective against most strains of malaria; however, it may not work against all strains.
Does Primalex cause loss of appetite?
Yes, Primalex can cause loss of appetite in some individuals.
When should I start taking Primalex?
Your doctor will advise you as to when you should start taking Primalex. It is typically recommended to start taking the medication 1-2 days prior to traveling to a malaria-endemic region.
Is Primalex safe to take if I have kidney problems?
Yes, Primalex is generally considered safe to take if you have kidney problems; however, your doctor may need to adjust the dose or monitor your condition more closely.
Can I take Primalex if I have high blood pressure?
Yes, Primalex can be taken if you have high blood pressure; however, your doctor may need to adjust the dose or monitor your condition more closely.
Can I take Primalex for longer than the recommended time?
No, Primalex should only be taken for the recommended time, as it can cause serious side effects if taken for longer than recommended.
Can Primalex be split in half?
Yes, Primalex tablets can be safely split in half in order to reduce the dose taken.
What are the symptoms of an overdose on Primalex?
Symptoms of an overdose on Primalex may include headache, nausea, dizziness, vomiting, and abdominal pain.
Can Primalex cause an allergic reaction?
Yes, Primalex can cause an allergic reaction in some individuals. Stop taking the medication and seek medical attention if you experience any symptoms of an allergic reaction, such as rash, itching, or swelling.
Is Primalex effective against Plasmodium falciparum malaria?
Yes, Primalex has been found to be effective against Plasmodium falciparum malaria.
Does Primalex cause hair loss?
No, Primalex does not typically cause hair loss.
Can I take Primalex if I'm breastfeeding?
No, Primalex should not be taken while breastfeeding, as it can pass into breast milk and cause harm to the baby.
Does Primalex need to be taken with food?
It is recommended to take Primalex with food to reduce the risk of stomach upset.
What should I do if I get an upset stomach while taking Primalex?
If you experience an upset stomach while taking Primalex, try taking the medication with food. If your symptoms persist, speak to your doctor.
Does Primalex cause drowsiness?
Yes, Primalex can cause drowsiness in some individuals. If you experience drowsiness, do not drive or operate machinery.