Pirilindole hydrochloride

Pirilindole hydrochloride Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pirilindole hydrochloride is a brand name. Its generic name is Pirlindole.

Pirilindole hydrochloride Introduction

Pirilindole hydrochloride is an atypical antidepressant drug from the phenylpiperidine class of compounds. It is a close structural analog to the well-known antidepressant drug trazodone. Pirilindole hydrochloride was first synthesized in 1955 and is primarily used in the treatment of major depressive disorder and other affective disorders.

Uses for Pirilindole hydrochloride

Pirilindole hydrochloride is used to treat major depressive disorder (MDD). It has been found to be effective in the treatment of depression with fewer side effects compared to other antidepressants such as tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). Pirilindole hydrochloride may also be used as part of a combination therapy for treatment-resistant depression or bipolar disorder.

Mechanism of Action

The exact mechanism of action of pirlindole is not yet established but it is believed to act on neurotransmitters in the brain including serotonin, norepinephrine, and dopamine. It is thought to increase serotonin and norepinephrine levels in the brain, which may improve overall symptoms of depression.

How Long Does it Take to Work?

The onset of action of pirlindole typically occurs within two to three weeks of starting treatment. During this time, a gradual improvement in depressive symptoms generally occurs and may further improve over the next several weeks of treatment.

Absorption, Route of Elimination, Dosage, Administration

Pirilindole hydrochloride is generally administered orally and is rapidly and well absorbed by the body. It is principally metabolized by the liver, though some of it is excreted unchanged in the urine. The recommended initial dose of pirlindole is 100-150 mg/day. Dosages can be increased to a maximum of 600 mg/day in divided doses of 100-150 mg every 4-6 hours.

Precaution, Interaction, Disease Interaction, Drug Interaction, Food Interactions, Pregnancy Use, Lactation Use, Acute Overdose, Contraindication, Use Direction, Storage Condition, Volume of Distribution, Half Life, Clearance

Pirilindole hydrochloride should be used with caution in patients who have a history of psychiatric disorder, cardiovascular disease, hepatic or renal impairment, and hyperthyroidism. It can also interact with other medications, diseases, foods and alcohol, and may be dangerous for pregnant or breastfeeding women, as the effects on the fetus or infant are not yet known. Pirilindole hydrochloride should be taken exactly as prescribed by the doctor, and any increase or decrease in dosage should be monitored closely. The volume of distribution of pirlindole is 0.8±0.3 L/kg and the half-life of the drug ranges from 14 to 20 hours. Approximately 70-80% of the total dose is excreted in the feces and the remaining 20-30% is excreted in the urine.

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