Phytomenadione
Phytomenadione Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Phytomenadione is a brand name. Its generic name is Phylloquinone.
Phytomenadione: Introduction
Phytomenadione (also known as vitamin K) is a fat-soluble vitamin essential for normal blood clotting and the protection of the cardiovascular system. Phytomenadione is found in green leafy vegetables, vegetable oils, dairy products, and liver. Phytomenadione is also known as phylloquinone-4 (or K1).Uses for Phytomenadione
Phytomenadione is a key component in the regulation of blood clotting. It helps to produce a protein called prothrombin, which is essential for the formation of blood clots. In addition, Phytomenadione also helps to prevent hardening of the arteries (atherosclerosis). It may also help to prevent heart disease, osteoporosis, and cancer.Mechanism of Action
Phytomenadione acts as a coenzyme in the gamma-glutamyl carboxylation of certain clotting factors (factors II, VII, IX, and X) needed for blood clotting. Phytomenadione also helps to convert Vitamin K-dependent proteins into active forms, allowing them to interact with calcium.How Long Does It Take to Work
Phytomenadione begins working within 1 to 2 days of taking it.Absorption
Phytomenadione is absorbed from the intestine in the presence of dietary fat. It is stored mainly in the liver.Route of Elimination
Phytomenadione is excreted in the bile.Dosage
The recommended daily intake of Phytomenadione for adults is 120 micrograms (mcg) per day. Postmenopausal women are advised to get more Phytomenadione (150 mcg per day). Pregnant women should get 90 mcg per day.Administration
Phytomenadione is available in dietary supplements and as an injection. It should be taken orally with food.Side Effect
Phytomenadione is generally well-tolerated. In rare cases, it may cause skin rash, nausea, and headache.Toxicity
Phytomenadione is not toxic in recommended doses.Precaution
Patients taking anticoagulants (e.g. warfarin) should use Phytomenadione with caution as it may interfere with the action of the drug.Interaction
Phytomenadione may interact with other medications, such as anticoagulants, corticosteroids, oral contraceptives, and certain antibiotics.Disease Interaction
Patients with liver or kidney diseases should use Phytomenadione with caution as it may be toxic in these conditions.Drug Interaction
Phytomenadione may interact with acetaminophen, aspirin, clopidogrel, ibuprofen, cefepime, penicillin G, metronidazole, and other drugs.Food Interactions
Phytomenadione may interact with foods containing Vitamin E, garlic, green tea, and soy.Pregnancy Use
Phytomenadione is considered to be generally safe for use in pregnancy. However, pregnant women should consult their doctor before taking Phytomenadione.Lactation Use
Phytomenadione is deemed safe for use during lactation. However, nursing mothers should consult their doctor before taking Phytomenadione.Acute Overdose
Symptoms of an acute overdose may include diarrhea, palpitations, dizziness, headache, and nausea.Contraindication
Phytomenadione should not be taken by patients who are known to be allergic to it.Use Direction
Phytomenadione should be taken orally with food. It should not be taken on an empty stomach.Storage Condition
Phytomenadione should be stored in a cool, dry place at room temperature (15-30C).Volume of Distribution
The volume of distribution of Phytomenadione is 0.14 l/kg.Half Life
The half-life of Phytomenadione is estimated to be 1.4 days.Clearance
The clearance of Phytomenadione is 24 l/hr/kg.Here you find in details version of Phytomenadione
Some Frequently Asked Questions About Phytomenadione
What is Phytomenadione?
Phytomenadione (also known as vitamin K1) is a vitamin found naturally in plants and used in dietary supplements as well as in the production of some pharmaceuticals and cosmetics. It is involved in important processes such as blood clotting, calcium absorption, and cell growth and differentiation.
What are the benefits of Phytomenadione?
Phytomenadione is most well-known for its role in regulating blood clotting. It also plays an important role in bone health, as it helps the body absorb and utilize calcium. Additionally, it is an antioxidant and may help protect against age-associated diseases.
What foods contain Phytomenadione?
Dark green leafy vegetables such as kale, spinach, and Swiss chard are some of the best sources of phylloquinone. Other foods that are rich in phylloquinone include broccoli, cabbage, cauliflower, Brussels sprouts, and collard greens.
How much Phytomenadione should I take?
The recommended daily intake for phylloquinone for adults over the age of 19 is 90-120 µg/day for men and 75-90 µg/day for women. It is important to talk to your doctor before taking any dietary supplement or medication to make sure the dosages are safe and appropriate.
Is Phytomenadione the same as Vitamin K?
Yes, Phytomenadione (vitamin K1) is the same as Vitamin K. Vitamin K can be divided into two categories, Vitamin K1 (phylloquinone) and Vitamin K2 (menaquinone), each with its own important sources and functions in the body.
Are there any side effects from taking Phytomenadione?
High doses of phylloquinone may in some cases cause adverse effects such as nausea, vomiting, diarrhea, and an increased risk of bruising. Additionally, because Phytomenadione can interfere with the effectiveness of certain medications, it is important to speak with a healthcare professional before taking a supplement.
Can I get Phytomenadione naturally from food?
Yes, Phytomenadione can be obtained naturally from food, and this is the best way for most people to get the recommended daily amount. Dark green leafy vegetables such as kale, spinach, Swiss chard, broccoli, cabbage, cauliflower, Brussels sprouts, and collard greens are some of the best sources of phylloquinone.
Can Phytomenadione be taken in combination with other vitamins?
Yes, Phytomenadione can be taken in combination with other vitamins safely. It is important to consult with a healthcare professional before taking any dietary supplement to make sure that dosage is appropriate and safe.
Are there any foods or drinks that I should avoid if I'm taking Phytomenadione?
Alcohol can reduce the amount of phylloquinone absorbed by the body, so it is best to limit alcohol consumption if you take a phylloquinone supplement. Additionally, it is important to speak to your doctor before taking any medications or supplements as they can interfere with the effectiveness of phylloquinone.
Does Phytomenadione affect the menstrual cycle?
Research has not conclusively shown that phylloquinone has any direct effects on the menstrual cycle. However, it is important to speak to your doctor before taking any supplement as it can have an effect on other hormones and medications.
How do I know if I'm deficient in Phytomenadione?
Common signs of a phylloquinone deficiency include easy bruising and bleeding, fatigue, and numbness or tingling in the extremities. If you experience any of these symptoms it is important to speak with your doctor to determine if you are indeed deficient in phylloquinone.
Can Phytomenadione help make my bones stronger?
Phytomenadione plays an important role in bone health, as it helps the body absorb and utilize calcium. Additionally, it is an antioxidant and may help protect against age-associated diseases. However, it is important to remember that vitamins and minerals can only do so much - regular exercise and nutritious eating habits are also important for bone health.
Where can I get Phytomenadione?
Phytomenadione is found in dark green leafy vegetables such as kale, spinach, Swiss chard, broccoli, cabbage, cauliflower, Brussels sprouts, and collard greens. It is also available in dietary supplement form in stores that carry vitamins and supplements.
Can Phytomenadione help with osteoporosis prevention?
Yes, research has shown that there is a link between higher intakes of vitamin K (phylloquinone) and lower risks of osteoporosis. However, as with any supplement, it is important to consult with your doctor before taking it to make sure it is appropriate and safe.
Does Phytomenadione have any interaction with other medications?
Yes, Phytomenadione can interact with certain medications, including antibiotics, anticoagulants, and anti-seizure medications. It is important to speak to your doctor before taking any supplement to make sure it is appropriate and safe to take with your medication.
Are there any medical conditions associated with Phytomenadione deficiency?
Yes, Phytomenadione deficiency can lead to a condition called Vitamin K deficiency bleeding (VKDB), which is a bleeding disorder that can affect infants, children, and adults. It is important to speak to your doctor if you have any signs or symptoms associated with a Vitamin K deficiency.
What are some natural sources of Phytomenadione?
Dark green leafy vegetables such as kale, spinach, Swiss chard, broccoli, cabbage, cauliflower, Brussels sprouts, and collard greens are some of the best natural sources of phylloquinone. It can also be found in certain fruits such as kiwi, grapes, and pineapple.
Can Phytomenadione be taken with other vitamins and supplements?
Yes, Phytomenadione can be taken in combination with other vitamins and supplements. It is important to talk to your doctor before taking any dietary supplement or medication to make sure the dosages are safe and appropriate.
Does Phytomenadione help to prevent cancer?
Research has suggested that phylloquinone may have a role in cancer prevention due to its antioxidant properties. However, more research is needed to fully understand the relationship between phylloquinone and cancer prevention.
Does Phytomenadione have any side effects?
High doses of phylloquinone may in some cases cause adverse effects such as nausea, vomiting, diarrhea, and an increased risk of bruising. Additionally, because Phytomenadione can interfere with the effectiveness of certain medications, it is important to speak with a healthcare professional before taking a supplement.
Does Phytomenadione increase blood clotting?
Yes, Phytomenadione is involved in the blood clotting process. It helps the body form a protein that is essential for normal blood clotting.
Can Phytomenadione be taken while pregnant or breastfeeding?
It is important to speak to your doctor before taking any dietary supplement while pregnant or breastfeeding. High doses of phylloquinone may cause side effects such as nausea and vomiting which could be dangerous for a pregnant or nursing woman.
What happens if I don't get enough Phytomenadione?
A deficiency in phylloquinone can lead to a condition called Vitamin K deficiency bleeding (VKDB), which is a bleeding disorder that can affect infants, children, and adults. Common signs of a deficiency include easy bruising and bleeding, fatigue, and numbness or tingling in the extremities.
Does Phytomenadione have anti-ageing effects?
Phytomenadione is an antioxidant and may help protect against age-associated diseases. Additionally, it helps the body absorb and utilize calcium, which is important for bone and joint health as you age.
Does Phytomenadione help with bone and joint health?
Yes, Phytomenadione plays an important role in bone health, as it helps the body absorb and utilize calcium. It is also an antioxidant, which may help protect against age-associated diseases such as osteoporosis. However, it is important to remember that vitamins and minerals can only do so much - regular exercise and nutritious eating habits are also important for bone health.
How long does it take for Phytomenadione to start working?
The effects of phylloquinone can vary from person to person. Generally speaking, it may take several weeks for the effects of phylloquinone to be felt, but it is important to consult with your doctor or healthcare professional to determine the right dosage for you.
Is it safe to take Phytomenadione supplements?
Yes, Phytomenadione is safe to take as a dietary supplement in the recommended dosages. However, it is important to speak to your doctor before taking any supplement or medication to ensure that the dosages are safe and appropriate.
Is Phytomenadione the same as Vitamin K2?
No, Phytomenadione (vitamin K1) is different from Vitamin K2 (menaquinone). Although they both serve similar functions, their sources and absorption methods are different. Vitamin K2 is found primarily in animal-based foods such as eggs, liver, and fermented dairy products, while Vitamin K1 is found primarily in dark green leafy vegetables.
Does Phytomenadione have any effect on the kidneys?
Research has not conclusively shown any direct effect of phylloquinone on the kidneys. However, it is important to consult with your doctor before taking any supplement to make sure that it does not interfere with any medications you may be taking.
Should I take Phytomenadione everyday?
It is important to speak to your doctor before taking any dietary supplement or medication. Depending on your doctor’s instructions, it may be advisable to take phylloquinone every day in order to meet the recommended daily intake.
Is Phytomenadione tied to any health risks?
High doses of Phytomenadione may cause adverse effects such as nausea, vomiting, diarrhea, and an increased risk of bruising. Additionally, because Phytomenadione can interfere with the effectiveness of certain medications, it is important to speak with a healthcare professional before taking a supplement.
What is the difference between Phytomenadione and Vitamin K2?
Phytomenadione (vitamin K1) and Vitamin K2 (menaquinone) are both vitamers of Vitamin K, which serve similar functions in the body. Vitamin K1 is found primarily in dark green leafy vegetables, while Vitamin K2 is found primarily in animal-based foods such as eggs, liver, and fermented dairy products.
Does the body store Phytomenadione?
No, the body does not store Phytomenadione, so it is important to obtain it through dietary sources or supplements. Phytomenadione is found in dark green leafy vegetables such as kale, spinach, Swiss chard, broccoli, cabbage, cauliflower, Brussels sprouts, and collard greens.
Does Phytomenadione have any effect on cholesterol levels?
Research has suggested that higher intakes of phylloquinone may be linked to lower levels of total cholesterol, as well as low-density lipoprotein (LDL), or “bad” cholesterol. However, more research is needed to confirm this potential link.
Can Phytomenadione be toxic if taken in large amounts?
Yes, phylloquinone can be toxic if taken in large amounts, and it is important to consult with your doctor before taking a supplement. High doses of phylloquinone may in some cases cause adverse effects such as nausea, vomiting, diarrhea, and an increased risk of bruising.