Perindopril Arginine

Perindopril Arginine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Perindopril Arginine is a brand name. Its generic name is Perindopril + Diuretika.

Introduction

Perindopril Arginine is a combination medication composed of a diuretic and an ACE inhibitor often used to treat high blood pressure and other related conditions. The diuretic component (furosemide) helps the body eliminate excess fluid, while the ACE inhibitor component (perindopril) helps to relax narrowed blood vessels. It comes in the form of oral tablets and can be taken either once or twice daily, depending on the individual's needs.

Uses

Perindopril Arginine is used to lower high blood pressure (hypertension). It works by helping the body get rid of excess fluid while also relaxing the narrowed blood vessels. It is also used in people with heart failure and certain other heart conditions. This medication may also be used to help prevent stroke or kidney problems in those with high blood pressure or diabetes.

Mechanism of Action

Perindopril+ Diuretika's mechanism of action is twofold: it works by helping to relax narrowed blood vessels (ACE inhibitors) and helping the body rid itself of excess fluid (diuretic). The ACE inhibitors portion of the medication helps to block an enzyme in the body that produces angiotensin II, a chemical that causes narrowing of the blood vessels. This in turn helps to reduce blood pressure and increases flow. The diuretic portion of the medication works by expelling excess water from the body, thus reducing overall blood volume.

How Long Does It Take To Work?

The effects of Perindopril Arginine can be felt fairly quickly, often within a few hours. Full effects may take up to two weeks to reach maximum effectiveness, however.

Absorption

Perindopril Arginine is rapidly absorbed from the gastrointestinal tract and is absorbed nearly completely. Peak concentrations of the medication generally occur within one to two hours.

Route of Elimination

Perindopril Arginine is predominantly eliminated in the urine, although some of the components are also eliminated in the bile.

Dosage

The dosage of Perindopril Arginine will vary depending on the individual and the condition being treated. It is important to follow the dosage instructions given by the doctor exactly as they are written. Generally, the medication is taken either once or twice daily, depending on the dose prescribed.

Administration

Perindopril Arginine should be taken orally. It can be taken with or without food. It is important to take the medication regularly, at around the same time every day.

Side Effects

Common side effects of Perindopril Arginine may include dizziness, muscle cramps, dry mouth, diarrhea, fatigue, and changes in taste. Less common side effects may include confusion, nightmares, anxiety, joint or muscle aches, depression, low blood pressure, and impotence.

Toxicity

The risk of toxicity with Perindopril Arginine is low and is usually due to an overdose. In high doses, it can cause low blood pressure, salt imbalances, and electrolyte imbalances.

Precautions

It is important to tell the doctor about all current medications, including vitamins and herbal supplements, before taking Perindopril Arginine. This medication should not be taken if already pregnant, as it could harm the fetus. If breastfeeding, it is important to check with the doctor before taking this medication. The doctor should also be notified of any history of heart or kidney problems, as this drug may affect these conditions.

Interactions

Certain drugs may interact with Perindopril Arginine. Some of these drugs include barbiturates, antifungal medications, calcium channel blockers, digoxin, lithium, & niacin. It is important to tell the doctor about all medications and supplements being taken before taking this medication.

Disease Interaction

This medication can interact with certain diseases or health conditions. It is important to tell the doctor about any history of angioedema, kidney disease, lupus, diabetes, and liver disease. It is important to tell the doctor about any allergies, as this medication may contain inactive ingredients that may cause an allergic reaction.

Drug Interactions

This medication may interact with certain drugs, including over-the-counter medications, vitamins, and herbal supplements. It is important to tell the doctor and pharmacist about all medications being taken before taking Perindopril Arginine.

Food Interactions

There are no known food interactions with Perindopril Arginine. It is still important to tell the doctor about any food allergies and dietary restrictions, however.

Pregnancy Use

Perindopril Arginine is not recommended for use in pregnant women, as it could potentially harm the fetus.

Lactation Use

It is not known if Perindopril Arginine is safe for use in women who are breastfeeding. It is important to tell the doctor if breastfeeding before starting this medication.

Acute Overdose

Symptoms of an acute overdose of Perindopril Arginine may include dizziness, lightheadedness, nausea, vomiting, rapid breathing, and confusion. If an overdose is suspected, it is important to seek medical attention immediately.

Contraindications

The use of Perindopril Arginine is contraindicated in certain patients. Those with angioedema or a history of an allergic reaction to ACE inhibitors should not take this medication. Additionally, those with severe renal impairment should not take this medication.

Use Direction

It is important to take Perindopril Arginine exactly as prescribed by the doctor. It should be taken orally with or without food, at around the same time every day.

Storage Condition

Perindopril Arginine should be stored in a cool, dry place away from excessive heat or light. It is important to keep this medication out of reach of children and pets.

Volume of Distribution

The volume of distribution for Perindopril Arginine is not known.

Half Life

Perindopril Arginine has a half-life of around 6 to 8 hours.

Clearance

The drug clearance of Perindopril Arginine is not known.

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