Periace
Periace Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Periace is a brand name. Its generic name is Perindopril Arginine.
Introduction
Perindopril arginine is a long-acting, blunt-acting angiotensin-converting-enzyme (ACE) inhibitor with antihypertensive properties. It is used for the treatment and prevention of heart failure, hypertension (high blood pressure), and post-myocardial infarction (heart attack). Its active metabolite perindoprilat is thought to act by blocking the angiotensin-converting-enzyme, resulting in a decrease in blood pressure.
Uses For
Perindopril arginine is used primarily for the treatment and prevention of heart failure, hypertension, and post-myocardial infarction.
Mechanism of Action
Perindopril arginine is a long-acting, blunt-acting angiotensin-converting-enzyme (ACE) inhibitor, blocking the angiotensin-converting-enzyme (ACE). This action causes an increase in bradykinin and prostaglandin levels, resulting in a decrease in blood pressure.
How Long Does it Take to Work?
Perindopril arginine may take several weeks to become fully effective, and the full effect may not be seen until 6-8 weeks after starting the drug. The drug should be used as directed by your doctor for optimal results.
Absorption
Perindopril arginine is rapidly absorbed following oral administration, with peak plasma levels within 1-4 hours. The bioavailability of perindopril is low (<25%) and is decreased with food.
Route of Elimination
Perindopril arginine is metabolized primarily via the liver into its active metabolite, perindoprilat, which is then excreted renally.
Dosage
The usual starting dose of Perindopril arginine is 2-4 mg daily, either as a single dose or divided into two doses. The recommended dose for the treatment of hypertension is 4-8 mg daily; the recommended dose for the treatment of high cholesterol is 8-32 mg daily. Higher doses may be necessary in some patients for adequate control of blood pressure.
Administration
Perindopril arginine should be taken orally with or without food. It is best to take the medication at the same time each day. If a dose is missed, take it as soon as possible and then continue taking it at the regular scheduled time.
Side Effects
The most common side effects of Perindopril arginine include dizziness, fatigue, headache, and cough. Other possible side effects include nausea, vomiting, diarrhea, abdominal pain, confusion, and weakness. These side effects may go away with continued use of the drug.
Toxicity
Perindopril arginine has a low toxicity. The drug is generally well-tolerated, but an overdose of the drug can cause serious, life-threatening side effects such as hypotension, bradycardia, arrhythmias, and shock.
Precautions
Before taking Perindopril arginine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This drug may contain inactive ingredients, which can cause allergic reactions or other problems. It is important to tell your doctor about any and all medications you are taking, including over-the-counter drugs, vitamins, and herbal supplements. Be sure to tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Interactions
Perindopril arginine can interact with other medications that may affect blood pressure, including diuretics, beta-blockers, and angiotensin-converting-enzyme inhibitors, so it is important to tell your doctor about all medications and supplements you are taking. It can also interact with drugs metabolized by CYP450 enzymes, such as certain antifungal medicines.
Disease Interaction
Perindopril arginine can worsen certain heart and kidney diseases, asthma, and diabetes and can interact with certain blood pressure medications. Consult your doctor for guidance if you have a pre existing condition.
Drug Interaction
Perindopril arginine can interact with other medications, including certain antifungal medications, and drugs metabolized by CYP450 enzymes. It is important to tell your doctor about all medications and supplements you are taking, including over-the-counter drugs, vitamins, and herbal supplements.
Food Interactions
Perindopril arginine should be taken with food or a light meal. It should not be taken with grapefruit or grapefruit juice.
Pregnancy Use
Perindopril arginine should not be used during pregnancy unless advised by your doctor. It may cause birth defects or fetal death if used in the third trimester of pregnancy.
Lactation Use
Perindopril arginine should not be used while breastfeeding, as it can pass into breast milk.
Acute Overdose
An overdose of Perindopril arginine can cause serious, life-threatening side effects, including hypotension, bradycardia, arrhythmias, and shock. Seek immediate medical attention if an overdose is suspected.
Contraindication
Perindopril arginine is contraindicated in patients with a history of angioedema, hyperkalemia, and in patients with kidney and liver impairment.
Use Direction
Perindopril arginine should be taken orally, with or without food, as prescribed by your doctor. The medication should be taken at the same time each day for optimal results.
Storage Condition
Perindopril arginine should be stored at room temperature. Keep the medication in a dry, dark place, out of reach of children and pets.
Volume of Distribution
The volume of distribution for Perindopril arginine is approximately 0.7 L/kg.
Half Life
The half life of Perindopril arginine is about 10 hours.
Clearance
The clearance for Perindopril arginine is approximately 5 mL/min/kg.
Here you find in details version of Periace
Some Frequently Asked Questions About Periace
What is Periace?
Periace is an angiotensin-converting enzyme (ACE) inhibitor medication used in the treatment of high blood pressure (hypertension) and congestive heart failure. It works by blocking a hormone that tightens blood vessels, allowing for a faster, more efficient blood flow throughout the body.
What are the side effects of Periace?
The most common side effects of Periace are a dry cough, fatigue, headaches, dizziness, and nausea. Less common side effects include blurred vision, tremors, changes in taste, and skin rash.
What is the recommended dosage for Periace?
The typical dosage of Periace is 4 mg once daily. Your doctor may adjust doses depending on how your body is responding to the medication.
How long does it take for Periace to work?
It can take up to four weeks for Periace to reach its full effect, however you should start to feel some of the benefits of the drug faster. It is important to take the medication as prescribed, and be patient with any positive changes.
Does Periace interact with other medications?
Periace may interact with other medications, so it is important to tell your doctor about all other medications you are taking before taking Periace. These drugs may include aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics, or lithium.
How should Periace be stored?
Store Periace in a cool, dry place that is away from direct sunlight, moisture, and heat. Keep the bottle tightly closed and out of reach of children.
Does Periace affect kidney function?
Periace does not usually have a direct effect on kidney function, however people with pre-existing kidney disease should be extra careful when taking this medication.
When I start taking Periace do I have to continue taking it?
Yes, if you have been prescribed Periace, it is important to continue taking it even if you are feeling better. Stopping the medication may result in a relapse of symptoms.
Can I take other medications when I'm on Periace?
Always consult your doctor before taking any other medications while on Periace. Some medications may interact and cause serious side effects.
Can I drink alcohol while I'm on Periace?
You should avoid alcohol while taking this medication, as the combination may increase the risk of side effects or reduce the effectiveness of the drug.
What should I do if I miss a dose of Periace?
If you miss a dose of Periace, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule.
Are there any foods I should avoid while taking Periace?
Most foods are safe to eat while taking Periace. However, it is recommended to limit your intake of high-sodium foods such as processed meats, canned soups, and pickles as they may interfere with the effectiveness of the medication.
Can I take Periace during pregnancy?
No, Periace is not recommended during pregnancy as it can cause serious harm to your baby. You should consult your doctor before taking this medication if you are pregnant or breastfeeding.
Is Periace available in generic form?
Yes, Periace is available in generic form as Perindopril Erbumine. Some brand names of the medication include Coversyl, Aceon, and Alenorm.
What age group should use Periace?
This medication is usually only prescribed to adults. It is not recommended for children under 18 years.
What should I do if I experience an allergic reaction to Periace?
If you experience any signs of an allergic reaction such as hives, swelling of the face, lips, throat, or difficulty breathing, you should stop taking the medication and get medical help immediately.
Do I need to take Periace every day?
Yes, it is important to take Periace as prescribed and at the same time every day. Skipping doses or not taking it regularly can reduce the effectiveness of the medication.
Can I take Periace with high cholesterol medication?
Yes, Periace can be taken with high cholesterol medications such as statins. However, always consult your doctor before taking any other medications while taking Periace.
What is the difference between Periace and other ACE inhibitors?
Periace is a long-acting ACE inhibitor that is more effective at controlling blood pressure than some other ACE inhibitors. It is generally well-tolerated with few side effects.
Does Periace cause weight gain?
No, Periace does not usually cause weight gain. In fact, it can even help reduce your weight by helping reduce fluid retention.
Does Periace work immediately?
No, it usually takes a few weeks for Periace to reach maximum effectiveness. It is important to take the medication as prescribed, and be patient with any positive changes.
Can I take Periace with ibuprofen?
Although it is possible to take Periace with ibuprofen, it is important to talk to your doctor first. Taking these two medications together may increase the risk of side effects such as dizziness, headaches, and nausea.
Does Periace interact with grapefruit?
Yes, grapefruit can interact with Periace and cause an increase in drug levels which can lead to serious side effects. Therefore, it is important to avoid grapefruit juice and other forms of grapefruit while taking this medication.
Is Periace effective in treating hypertension?
Yes, Periace is commonly used to treat high blood pressure (hypertension) as it works to relax the blood vessels and reduce the risk of stroke and heart attack. Studies have also found that Periace may help improve cholesterol levels.
Are there any precautions I should take when taking Periace?
When taking Periace, it is important to inform your doctor about any other medications you may be taking, especially those that can reduce the effectiveness of the drug such as ibuprofen and ACE inhibitors. Be aware of any potential side effects, and get medical help if you experience any allergic reactions such as hives, swelling of the face, lips, throat, or difficulty breathing.
Does Periace have any long-term effects?
At appropriate doses, the long-term safety of Periace is well established. Regular check-ups with your doctor are important to assess your progress and monitor any potential side effects.
Can Periace be used to treat other conditions?
Periace is primarily used to treat hypertension and congestive heart failure. However, it may also be prescribed to reduce the risk of stroke and heart attack in people with high blood pressure.
If I take more than the recommended dose of Periace, what should I do?
If you take more than the recommended dose of Periace, seek medical help immediately, as it could be dangerous. Symptoms of an overdose may include dizziness, fainting, difficulty breathing, and confusion.
Can I start taking Periace if I'm a smoker?
Yes, however smoking may interfere with the effectiveness of Periace, so it is important to inform your doctor if you are a smoker. It is also advised to quit smoking if possible.
Can Periace be used to treat angina?
Yes, Periace can be used to treat angina, as it works to reduce the workload on the heart and help improve blood flow. It is also effective in reducing the risk of stroke and heart attack.
Can I take Periace if I have diabetes?
Yes, Periace can be taken by people with diabetes. However, it is important to monitor your blood sugar levels regularly as the medication may affect your levels.
Can I continue exercising while taking Periace?
Yes, it is generally safe to exercise while taking Periace, as it can help reduce your blood pressure and improve your overall heart health. However, it is important to talk to your doctor before starting any exercise routine and to stop exercising if you experience any dizziness or headaches.
Does Periace affect blood sugar levels?
Yes, Periace can affect blood sugar levels. Therefore, it is important to monitor your blood sugar levels regularly while taking this medication.
Can I take Periace if I'm taking other blood pressure medications?
Yes, it is possible to take Periace with other blood pressure medications. However, it is important to talk to your doctor before taking any additional medications as some may interact with Periace and increase the risk of side effects.
Can I take Periace with antacids?
Yes, it is generally safe to take Periace with antacids. However, it is important to talk to your doctor before taking these medications, as antacids can reduce the effectiveness of Periace in some cases.
How long does it take for Periace to be absorbed into the body?
Periace is usually fully absorbed into the body within 2-3 hours after taking the medication. However, it can take 4 weeks for the drug to reach its full effectiveness.
What is the difference between Periace and Ramipril?
Periace and Ramipril are both ACE inhibitors used in the treatment of high blood pressure. The main difference between the two is that Periace is a long-acting ACE inhibitor which is more effective at controlling blood pressure.
Is Periace safe to take with insulin?
Yes, it is usually safe to take Periace with insulin. However, it is important to talk to your doctor before taking any other medications while taking Periace as some may interact and cause serious side effects.
Can I take Periace while breastfeeding?
No, it is not recommended to take Periace while breastfeeding as it may be passed from mother to child through breast milk. You should consult your doctor before taking this medication if you are breastfeeding.