Pan-Oxacillin

Pan-Oxacillin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Pan-Oxacillin is a brand name. Its generic name is Oxacillin Sodium.

Introduction

Oxacillin sodium is an antibiotic of the penicillin class used to treat various bacterial infections. It is used to treat infections of the skin, respiratory system, and urinary tract infections. Oxacillin sodium is effective against a range of bacteria, including Gram-positive and Gram-negative bacteria. It was first approved for medical use in 1972.

Uses

Oxacillin sodium is primarily used to treat skin, respiratory tract, and urinary tract infections. It is also used to treat streptococcal sepsis, endocarditis, meningitis, pneumonia, and peritonitis caused by susceptible organisms.

Mechanism of Action

Oxacillin sodium acts by inhibiting the transpeptidase enzyme in the bacterial cell wall, which prevents bacteria from building new cell walls. As a result, the bacteria cannot reproduce and is eventually destroyed.

How long does it take to work?

The effects of oxacillin sodium will begin to appear within 48-72 hours of taking the medication, and the full course should be taken for the best results.

Absorption

Oxacillin sodium is rapidly and completely absorbed from the gastrointestinal tract.

Route of Elimination

Oxacillin sodium is eliminated from the body via the kidneys.

Dosage and Administration

Oxacillin sodium is available in oral and intravenous forms. The recommended dose of oxacillin sodium is 250-500 mg (in adults) to be taken orally every 4-6 hours or intravenously every 4-8 hours, depending on the severity of the infection and the susceptibility of the bacteria.

Side Effects

The most common side effects of oxacillin sodium are diarrhea, nausea, vomiting, rash, and headache. Other side effects may include joint pain, fever, confusion, dizziness, and blurred vision.

Toxicity

Oxacillin sodium has low toxicity. A single overdose is unlikely to cause serious harm, but repeated overdoses can cause kidney or liver damage.

Precautions

Patients with renal impairment, seizure disorders, or a history of allergy to penicillins should use oxacillin sodium with caution. Oxacillin sodium should not be used in pregnant women, as it may have adverse effects on the fetus.

Interactions

Oxacillin sodium should not be used in combination with other antibiotics that may reduce its effectiveness. Additionally, it may interact with anticoagulants, probenecid, or barbiturates and should be used cautiously in patients taking these medications.

Disease Interactions

Oxacillin sodium should not be used in patients with active fungal infections or in those with a history of allergies to penicillins.

Drug Interactions

Oxacillin sodium may interact with other medications, such as anticoagulants, probenecid, or barbiturates, and should be used cautiously with these medications.

Food Interactions

Oxacillin sodium can be taken with or without food.

Pregnancy Use

Oxacillin sodium is not recommended for use during pregnancy, as it may have adverse effects on the fetus.

Lactation Use

The safety of oxacillin sodium during breastfeeding is not well studied.

Acute Overdose

A single acute overdose of oxacillin sodium is unlikely to cause serious harm. However, larger doses or repeated overdoses can lead to liver or kidney damage.

Contraindications

Oxacillin sodium should not be used in patients with active fungal infections or in those with history of allergies to penicillins.

Use Directions

Oxacillin sodium should be taken as directed by your physician. It should be taken with a full glass of water.

Storage Conditions

Oxacillin sodium should be stored at room temperature and away from heat and moisture.

Volume of Distribution

The volume of distribution of oxacillin sodium varies from 0.3 to 0.5 L/kg.

Half Life

The half-life of oxacillin sodium is 0.5 to 1 hour.

Clearance

Oxacillin sodium has a clearance rate of 0.25 to 0.5 ml/min/kg.

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