Oxprenolol
Oxprenolol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Oxprenolol is a brand name. Its generic name is Oxprenolol.
Oxprenolol Introduction
Oxprenolol is a beta-blocker drug typically used to treat high blood pressure, angina, and certain types of heart arrhythmias. It works by blocking certain messages to the heart and blood vessels to help reduce blood pressure, which helps treat or prevent various cardiovascular conditions.
Uses for
Oxprenolol is used to treat high blood pressure (hypertension). It is also used to treat angina due to coronary artery disease, certain heart arrhythmias, and hypertrophic subaortic stenosis (thickness of the wall of the aorta). Oxprenolol may also be used to treat other conditions as determined by your doctor.
Mechanism of Action
Oxprenolol works by blocking certain receptors found in the heart and blood vessels. This reduces the force of heart contractions, allowing the heart to beat more slowly and, in turn, reducing blood pressure. Oxprenolol is also thought to reduce workload on the heart by widening blood vessels, allowing blood to flow more easily.
How Long Does It Take To Work?
For most people, Oxprenolol will start to work within an hour of taking the first dose. However, it can take up to three months for the drug to reach its full effect.
Absorption
Oxprenolol is rapidly and almost completely absorbed from the gastrointestinal tract, with peak concentrations occurring 2 to 4 hours after an oral dose. Its bioavailability is 98%. The drug is widely bound to plasma proteins, including albumin, alpha-1-acid glycoprotein, and globulins.
Route of Elimination
The elimination of oxprenolol occurs mainly through metabolism, with only trace amounts being excreted unchanged in the urine. Oxprenolol is metabolized in the liver to several active metabolites.
Dosage
The usual dosage of oxprenolol for high blood pressure in adults is 20 to 40 mg per day in divided doses. The usual starting dose is 10 mg once daily in the morning. The maximum recommended dose is 60 mg per day. For angina, the usual starting dose is 10 mg three times daily. The maximum recommended dose is 120 mg per day.
Administration
Oxprenolol can be taken with or without food. It should be taken exactly as prescribed. It is important to not stop taking this medication abruptly as it may cause serious adverse reactions. If you need to stop taking oxprenolol for any reason, your doctor should slowly decrease the dose over several weeks.
Side Effect
Common side effects of oxprenolol include, but are not limited to, nausea, headache, dizziness, fatigue, depression, and rash. Less common side effects can include blurred vision, tingling or numbness in the extremities, chest pain, and difficulty breathing.
Toxicity
Oxprenolol is generally well tolerated. Overdose can lead to severe hypotension, bradycardia, dizziness, nausea, weakness, and fatigue. If an overdose is suspected, seek medical attention immediately.
Precaution
Oxprenolol should not be used if you have a history of bradycardia, heart failure, asthma, or diabetes. It may also not be suitable if you are pregnant or breastfeeding. Tell your doctor if you have any allergies, are taking any other medications, or if you have had any other medical conditions.
Interaction
Oxprenolol may interact with other drugs, including steroids, nonsteroidal anti-inflammatory drugs, antifungal medications, calcium channel blockers, and certain types of diuretics. Tell your doctor all medications and supplements that you are taking.
Disease Interaction
Oxprenolol may not be suitable for people with certain medical conditions, including bronchospasm, pheochromocytoma, and sick sinus syndrome. Tell your doctor about all medical conditions you have before starting to take oxprenolol.
Drug Interaction
Oxprenolol can interact with several other drugs, including steroids, nonsteroidal anti-inflammatory drugs, antifungal medications, calcium channel blockers, and certain types of diuretics. Tell your doctor about all medications and supplements that you are taking to avoid potential drug interactions.
Food Interactions
Oxprenolol can interact with certain foods. Avoid taking this medication with food that contains tyramine, such as aged cheese, smoked fish, pickled herring, or liver; high doses of caffeine; and large amount of alcohol. These foods may increase the side effects of oxprenolol.
Pregnancy Use
Oxprenolol should not be used during pregnancy. It is a category C drug, which means it may be harmful to an unborn baby. Tell your doctor if you are pregnant before starting this medication.
Lactation Use
Oxprenolol is not recommended for use during lactation. It is not known if this medication passes into breast milk. Speak to your doctor before taking oxprenolol if you are breastfeeding.
Acute Overdose
If you suspect an overdose, seek emergency medical help. Symptoms of an oxprenolol overdose may include dizziness, shortness of breath, slow heartbeat, and fainting.
Contraindication
Oxprenolol is contraindicated in certain medical conditions, including bronchospasm, pheochromocytoma, sick sinus syndrome, and during pregnancy. It should also not be used if you have a known hypersensitivity to this medication.
Use Direction
Oxprenolol should be taken exactly as prescribed. The recommended dose is 10 mg three times daily. Do not take more than the prescribed dose, as this can cause serious side effects. Your doctor may adjust the dosage as needed. Do not stop taking the medication without consulting your doctor.
Storage Condition
Oxprenolol should be stored at room temperature, away from moisture and light. Keep the medication in a tightly closed container and out of reach of children.
Volume of Distribution
The volume of distribution of oxprenolol is 1.3 L/kg.
Half-life
The half-life of oxprenolol is 8 to 12 hours.
Clearance
The renal clearance of oxprenolol is 6.2 mL/min/kg.
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