Ovidrel 250
Ovidrel 250 Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ovidrel 250 is a brand name. Its generic name is Choriogonadotropin alfa.
Choriogonadotropin Alfa
Choriogonadotropin Alfa is an injectable human chorionic gonadotropin (hCG) analog used in the treatment of infertility, delayed puberty, and certain cancers. It is produced from recombinant DNA technology and works through stimulation of the gonadal hormone production in the body.
Uses
Choriogonadotropin Alfa is primarily used for the treatment of infertility, inducing ovulation, delayed puberty, and treating testicular and ovarian cancers. It is also used for treating certain gynecological conditions, such as endometriosis. It is also used for improving semen parameters and has been used as an adjunct to fertility treatments.
Mechanism of Action
Choriogonadotropin Alfa works by stimulating the gonadal hormone production. This leads to the release of pituitary gonadotropin, which in turn stimulates the production of the gonadal hormones needed for fertility. The resulting increase in ovarian and testicular hormones leads to the stimulation of ovulation or production of the testosterone and follicle-stimulating hormone.
How long does it take to work?
Choriogonadotropin Alfa usually takes several weeks to begin working, although it can take up to several months in some cases. The effects of the medication vary depending on the individual, the dosage, and the medical condition being treated.
Absorption
Choriogonadotropin Alfa is rapidly absorbed when injected intramuscularly with peak levels achieved around 10 minutes post-injection. It is also rapidly metabolized and excreted but still has a long half-life of 3-5 days.
Route of Elimination
Choriogonadotropin Alfa is rapidly eliminated via the kidneys. The metabolic breakdown products are eliminated in the urine.
Dosage
Dosage information is as follows. It should always be given intramuscularly in the upper outer quadrant of the buttock.
- Fertility treatment: 5,000 units intramuscular once or twice a day starting near mid-cycle (cycle days 7-9)
- Delayed puberty: 250-500 units intramuscular 3 times a week
- Endometriosis: 5,000-10,000 units intramuscular 1-2 times per week
- Gonadal tumors: 10,000-20,000 units intramuscular 2-3 times per week
Administration
Choriogonadotropin Alfa should only be administered as intramuscular injection. It should not be administered intravenously or subcutaneously.
Side Effects
Common side effects of Choriogonadotropin Alfa include redness, pain, or swelling at the injection site and reactions such as nausea, dizziness, restlessness, and muscle aches.
Toxicity
The toxicity of Choriogonadotropin Alfa has not been established. Overdose can cause side effects and may result in serious complications.
Precautions
Choriogonadotropin Alfa should be used with caution in patients with a history of stroke or thromboembolism and in those predisposed to urinary tract infections. It should be used with caution in the elderly and patients with renal impairment. It is not recommended in pregnant women and should be avoided in lactating mothers.
Interaction
Choriogonadotropin Alfa may interact with certain drugs, including certain antibiotics, antiestrogens, antihistamines, antifungal drugs, antipsychotics, estrogen-containing medications, hormones, and HIV drugs. It may also interact with certain natural herbs and supplements, such as ginseng and St. John’s Wort.
Disease Interaction
Choriogonadotropin Alfa may interact with certain diseases, such as cirrhosis, diabetes, epilepsy, kidney disease, liver disease, and thyroid disease. It should not be used in patients with uncontrolled hypertension or mild to moderate hepatic impairment.
Drug Interactions
Choriogonadotropin Alfa may interact with certain drugs, such as aromatase inhibitors, bisphosphonates, cyclophosphamide, ibuprofen, lansoprazole, warfarin, and certain macrolides such as clarithromycin and erythromycin. It should not be used in combination with certain drugs, such as antidiabetic agents, anticoagulants, and antihypertensives.
Food Interactions
Choriogonadotropin Alfa may interact with certain foods, such as dairy products, soy products, and certain vegetables. It is important to consult with a doctor before taking Choriogonadotropin Alfa with food.
Pregnancy Use
Choriogonadotropin Alfa is not recommended for use in pregnant women. It has the potential to cause serious harm to a fetus and should be avoided during pregnancy.
Lactation Use
Choriogonadotropin Alfa is not recommended for use in women who are breastfeeding. It has the potential to harm a nursing infant and should be avoided during lactation.
Acute Overdose
Acute overdose of Choriogonadotropin Alfa may cause serious side effects. If an overdose is suspected, immediate medical help should be sought.
Contraindications
Choriogonadotropin Alfa is contraindicated in patients with known hypersensitivity to the drug or any of its components, in women with ovarian cysts or that are pregnant, and in patients with malignant neoplasms.
Use Direction
Choriogonadotropin Alfa should be used according to your doctor’s instructions. The dosage and duration of treatment will depend on the condition being treated and your response to the drug.
Storage Conditions
Choriogonadotropin Alfa should be stored at room temperature, away from light and moisture. Do not freeze the product and keep it out of reach of children.
Volume of Distribution
The volume of distribution of Choriogonadotropin Alfa is approximately 24 L.
Half life
The half-life of Choriogonadotropin Alfa is approximately 3-5 days.
Clearance
The clearance of Choriogonadotropin Alfa is approximately 2.2 L/h.
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