orencia
orencia Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? orencia is a brand name. Its generic name is Abatacept.
About orencia
orencia is a medication used to treat various inflammatory diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis. It is given as an injection under the skin or into a vein. orencia works by targeting and blocking specific pathways involved in the body's inflammatory response.
Uses for orencia
orencia is used to treat adults and pediatric patients with:
- Rheumatoid arthritis
- Juvenile idiopathic arthritis
- Psoriatic arthritis
Mechanism of Action
orencia works by blocking a process involved in the body's response to inflammation, particularly during an autoimmune disease. Its main function is to block the interaction between T-cells and antigen-presenting cells ( cells that present antigens, molecules that induce an immune response). This interaction is mediated by co-stimulatory molecules, such as CD80/86, which, when blocked, hinder the T-cells from producing a response, ultimately leading to a decrease in inflammation.
How Long Does It Take to Work?
The effects of orencia are usually seen within days or weeks of starting treatment. The exact length of time may vary from patient to patient, depending on their condition and response to the drug.
Absorption
orencia is well absorbed after a single subcutaneous and intravenous administration. After the subcutaneous administration of abatacept, the maximum concentrations of the drug are usually achieved within 2 to 3 hours.
Route of Elimination
orencia is primarily eliminated by the kidneys and the hepatic system. It is eliminated mainly as intact drug in the bile and urine, with only a small amount of unchanged drug present in the feces.
Dosage
The recommended dose of abatacept for treating adult patients with rheumatoid arthritis is an intravenous infusion of 10 mg/kg once a week, or subcutaneous administration of 125 mg once a week. For treating adult patients with juvenile idiopathic arthritis, the recommended dose is an intravenous infusion of 10 mg/kg once a week, or subcutaneous administration of 125 mg every other week. The dose for psoriatic arthritis is an intravenous infusion of 10 mg/kg once a week, or subcutaneous administration of 125 mg every week.
Administration
orencia is administered either as an intravenous infusion or as a subcutaneous injection. It is usually given once a week or every other week depending on the condition being treated.
Side Effects
Common side effects of abatacept include fatigue, headache, nausea, upper respiratory infection, and muscle pain. Serious side effects include serious allergic reactions, changes in liver function tests, and an increased risk of cancer.
Toxicity
orencia is generally well tolerated. The most commonly reported serious adverse events were serious infections, malignancies, and neutropenia. It is important to contact a doctor immediately if any serious side effects are experienced during treatment.
Precautions
Before starting abatacept, discuss your medical history with your doctor, including any current medications. Be sure to inform your doctor of any allergies to medications, especially those related to immunosuppressant and biologic therapies. Inform your doctor immediately if any signs of infection or serious side effects develop during the treatment.
Interactions
orencia may interact with other medications, such as certain immunosuppressants, corticosteroids, and certain antibiotics. It may also interact with some herbal products and dietary supplements. Therefore, it is important to inform your doctor of any and all medications, herbs, or supplements you are taking before starting treatment with abatacept.
Disease Interaction
orencia should not be used in patients with active infections. It is not recommended for use in patients with a history of recurrent infections or with moderate to severe heart failure. orencia may also increase the risk of cancer, particularly in patients with a history of malignancies.
Drug Interaction
orencia may interact with certain antibiotics, immunosuppressants, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, antidepressants, and oral antidiabetic drugs. It may also interact with some other medications, including herbal products and dietary supplements. Therefore, inform your doctor of all such medications before you start taking abatacept.
Food Interactions
orencia has no known food interactions. However, avoid drinking alcohol when taking abatacept, as it may increase the risk of certain side effects. Talk to your doctor before consuming alcohol while on this medication.
Pregnancy Use
orencia is not to be used while pregnant, as it may harm the unborn baby. Women of childbearing age should use effective birth control when taking this medication. If you become pregnant while taking abatacept, contact your doctor for advice.
Lactation Use
It is not known if abatacept is safe to use during lactation. Therefore, it is recommended to avoid taking this medication while breastfeeding. Talk to your doctor to decide what is best for you and your baby.
Acute Overdose
In the case of an acute overdose, contact your local poison control center or seek emergency medical help immediately. Symptoms may include nausea, vomiting, confusion, dizziness, sleepiness, and changes in breathing and heart rate.
Contraindication
orencia is contraindicated in patients with active infections, or a history of recurrent or severe infections. It should also be used with caution in patients with a history of malignancy. Also, patients receiving abatacept should not receive concurrent live or live-attenuated vaccines.
Use Direction
orencia should be taken as directed by your doctor. Your doctor will advise you on the dosage, frequency, and duration of your treatment. It is important to take abatacept exactly as instructed. Do not stop taking it without talking to your doctor first.
Storage Conditions
Store abatacept at room temperature, away from moisture and light. Do not freeze or refrigerate the medication. Keep out of the reach of children.
Volume of Distribution
The volume of distribution of orencia is approximately 6 L/kg.
Half Life
The half-life of orencia is approximately 7-9 days.
Clearance
The total clearance of orencia is approximately 200 mL/min/kg.
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