Ofloxacin & Ornidazole

Ofloxacin & Ornidazole Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ofloxacin & Ornidazole is a brand name. Its generic name is Ofloxacin + Ornidazole.

Introduction

Ofloxacin & Ornidazole is an antibiotic combination prescribed to treat certain bacterial infections in the body. It is a combination of two medicines- Ofloxacin and Ornidazole, which belong to a group of medicines called quinolones (or fluoroquinolones) and nitroimidazoles respectively.

Uses

Ofloxacin & Ornidazole is used to treat bacterial infections that affect the digestive system, lungs, skin and genitourinary system such as:

  • Acute pelvic inflammatory disease
  • Community-acquired pneumonia
  • Abscesses
  • Gynecological infections
  • Prostatitis
  • Folliculitis in overweight patients
  • Trichomoniasis
  • Gastroenteritis
  • Septic arthritis

Mechanism of Action

Ofloxacin belongs to the fluoroquinolones group of antibiotics that inhibit bacterial DNA gyrase activity, thus inhibiting synthesis and repair of bacterial DNA. Ornidazole is a nitroimidazole derivative, which inhibits DNA replication in protozoan organisms.

How Long Does It Take To Work?

Ofloxacin & Ornidazole typically takes about 4 to 7 days for the full effect to be seen. Some people may see improvement even sooner.

Absorption

Ofloxacin is rapidly and almost completely absorbed after oral administration. It has an absorption half-life of about two hours. Ornidazole has a rapid and nearly complete absorption from the gastrointestinal tract if taken on an empty stomach. Its absorption is decreased if taken with food.

Route of Elimination

Ofloxacin is eliminated primarily via renal or biliary route, while Ornidazole is eliminated via renal as well as fecal route.

Dosage

  • Oral: 400 mg of Ofloxacin and 500 mg of Ornidazole once every 12 hours for 5 days.
  • Intravenous: 200 mg of Ofloxacin and 500 mg of Ornidazole every 12 hours for 5 days.

Administration

Oral: This tablet should be taken with water and can be taken with or without food. Intravenous: The solution should be given as an intravenous infusion over 60 minutes at an infusion rate not exceeding 2 mg/minute.

Side Effects

  • Headache
  • Dizziness
  • Blurred vision
  • Nausea
  • Diarrhea
  • Skin rash
  • Fever
  • Abdominal pain

Toxicity

Overdose of Ofloxacin & Ornidazole can lead to severe toxic effects. These include nervous system effects such as weakness, tremors, confusion, hallucinations, etc. Other effects include nausea, vomiting, diarrhoea and increased heartbeat.

Precaution

Ofloxacin & Ornidazole should not be taken if you are allergic to any ingredient in it, have kidney or liver disease, or have a history of seizures. It is not recommended for use in pregnant or breastfeeding women. Tell your healthcare provider about all other medications you may be taking.

Interaction

Ofloxacin & Ornidazole can interact with several drugs, including anticoagulants, anti-epileptics, oral contraceptives, glyburide, probenecid, sucralfate, and antacids, which can lead to serious adverse effects. Before taking Ofloxacin & Ornidazole, inform your healthcare provider about all your prescriptions, non-prescription medications, herbal products, and dietary supplements.

Disease interaction

Ofloxacin & Ornidazole should be used with caution in patients with impaired kidney or liver function since it can increase the risks of adverse effects due to drug accumulation.

Drug interaction

Ofloxacin & Ornidazole can interact with some other drugs and may increase or decrease the efficacy or toxicity of a medicine. Therefore, be sure to tell your healthcare provider about all the medications you are taking before starting this drug to reduce the risk of any possible drug interaction or side effect.

Food interaction

When taken with or after a high-fat meal, the absorption of Ofloxacin & Ornidazole is significantly reduced. Therefore, it is recommended to take this medication one hour before or after a meal.

Pregnancy use

Ofloxacin & Ornidazole is not recommended for use during pregnancy. It is suggested to be used only if the potential benefit justifies the potential risk to the fetus.

Lactationuse

It is not known whether Ofloxacin & Ornidazole is excreted in human milk. Therefore, it is best to avoid its use in nursing mothers.

Acute overdose

An acute overdose of Ofloxacin & Ornidazole can lead to nausea, vomiting, seizures, confusion, tremors, and hallucinations. Seek immediate medical help if an overdose is suspected.

Contraindication

Ofloxacin & Ornidazole should not be used in people with known hypersensitivity to either of the medications. It should also be avoided in patients who have a history of seizure disorders or in people who have kidney or liver dysfunction.

Use Direction

Ofloxacin & Ornidazole should be taken exactly as prescribed by the doctor. It should be taken with or without food and the dose as determined by the healthcare provider should not be changed without the doctor's advice.

Storage Condition

The tablets should be stored at 20-25 °C, away from direct light and moisture.

Volume of Distribution

The volume of distribution of Ofloxacin is 2.7-2.9 L/kg and Ornidazole is 1.5-3.3 L/kg.

Half-life

The half-life of Ofloxacin is 3.8-6.7 hours and that of Ornidazole is 7.9 hours.

Clearance

The clearance of Ofloxacin is 0.11 L/hr/kg and that of Ornidazole is 0.027 L/h/kg.

Here you find in details version of Ofloxacin & Ornidazole

Some Frequently Asked Questions About Ofloxacin & Ornidazole

What is Ofloxacin & Ornidazole?

Ofloxacin+Ornidazole is a combination medication containing ofloxacin, an antibiotic, and ornidazole, an antiprotozoal/antibacterial agent. It is used for treating certain bacterial infections, such as bacterial vaginosis, urinary tract infections, and skin and soft tissue infections.

What is the purpose of Ofloxacin & Ornidazole?

Ofloxacin+Ornidazole is used to treat certain types of bacterial infections, including those affecting the skin, urinary tract, and vagina. It can also be used to treat certain intestinal infections.

How does Ofloxacin & Ornidazole work?

Ofloxacin+Ornidazole uses its two active ingredients, ofloxacin and ornidazole, to work against bacteria and other kinds of protozoa. Ofloxacin works by stopping the bacteria from making its own DNA, while Ornidazole stops them from reproducing.

What are the possible side effects of Ofloxacin & Ornidazole?

Common side effects of Ofloxacin+Ornidazole can include nausea, vomiting, upset stomach, headache, dizziness, diarrhea, and rash. More serious side effects are rare but can include fever, joint pain, yellowing of the skin and eyes, dark urine, and abdominal pain. If you experience any of these side effects, stop taking the medicine and speak to your doctor or pharmacist right away.

Who should not take Ofloxacin & Ornidazole?

Ofloxacin+Ornidazole should not be taken by those with a known sensitivity or allergy to either of its active ingredients, pregnant or breastfeeding women, or people with kidney or liver disease. People with heart conditions or taking blood thinning medications should also not take Ofloxacin+Ornidazole without speaking to their doctor or pharmacist first.

How long should I take Ofloxacin & Ornidazole?

Your doctor will usually recommend taking Ofloxacin+Ornidazole for seven to ten days to treat bacterial infections, as well as any longer-term recommendations for recurrent infections. Do not take it for longer than prescribed. It is important to keep taking Ofloxacin+Ornidazole until the course is finished, even if you feel better.

What should I do if I miss a dose of Ofloxacin & Ornidazole?

If you miss a dose of Ofloxacin+Ornidazole, take it as soon as possible. However, if it is almost time for the next dose, do not take the missed dose and take the next dose as scheduled. Do not take a double dose.

Can I take Ofloxacin & Ornidazole with other medications?

Ofloxacin+Ornidazole can interact with other medications. Speak to your doctor or pharmacist before taking any other medications, including vitamins or supplements, while taking Ofloxacin+Ornidazole.

What should I do if I experience an allergic reaction to Ofloxacin & Ornidazole?

If you experience any signs or symptoms of an allergic reaction, such as rash, itching, chest tightness, dizziness, difficulty breathing, or swelling of the face, lips, tongue, or throat, stop taking Ofloxacin+Ornidazole and speak to your doctor or pharmacist immediately.

Is Ofloxacin & Ornidazole safe to take while pregnant or breastfeeding?

No, Ofloxacin+Ornidazole is not safe to take while pregnant or breastfeeding. Speak to your doctor or pharmacist before taking any medication while pregnant or breastfeeding.

Can I drink alcohol while taking Ofloxacin & Ornidazole?

No, you should not drink alcohol while taking Ofloxacin+Ornidazole. Alcohol can interfere with the effectiveness of the medication and can also increase the risk of side effects.

What should I do if I experience any side effects from taking Ofloxacin & Ornidazole?

If you experience any side effects while taking Ofloxacin+Ornidazole, speak to your doctor or pharmacist right away. Some side effects may require you to stop taking the medication and/or seek medical treatment.

What is the recommended dosage of Ofloxacin & Ornidazole?

The recommended dosage of Ofloxacin+Ornidazole is 500mg of ofloxacin and 500mg of ornidazole for adults and children over the age of 12. Children under the age of 12 should be given half the adult dose or as prescribed by a doctor. Speak with your doctor or pharmacist if you are unsure about the correct dosage.

Can Ofloxacin & Ornidazole be taken with food?

Ofloxacin+Ornidazole can be taken with food or on an empty stomach. Speak with your doctor if you have any questions or concerns about taking the medication.

Can I drive while taking Ofloxacin & Ornidazole?

You may be able to drive while taking Ofloxacin+Ornidazole, however this is dependent on how you feel while taking the medication. If you experience any dizziness or drowsiness after taking the medication, avoid driving or operating heavy machinery until you are certain you can do so safely.

Does Ofloxacin & Ornidazole interact with other medications?

Yes, Ofloxacin+Ornidazole can interact with other medications. It is important to speak with your doctor or pharmacist before starting any other medication while taking Ofloxacin+Ornidazole, including any over-the-counter medications, vitamins or supplements.

Can Ofloxacin & Ornidazole be used to treat other conditions?

Ofloxacin+Ornidazole can be used to treat other conditions, but only as prescribed by a doctor. Speak with your doctor if you are experiencing any other medical conditions and require treatment.

Is Ofloxacin & Ornidazole available over the counter?

No, Ofloxacin+Ornidazole is not available over the counter. It is a prescription medication and must be taken as prescribed by a doctor.

What should I do if I overdose on Ofloxacin & Ornidazole?

If you believe you have overdosed on Ofloxacin+Ornidazole, seek medical attention right away. Symptoms of an overdose may include stomach pain, nausea, vomiting, headache, confusion, and drowsiness.

Can Ofloxacin & Ornidazole be taken with other antibiotics?

No, Ofloxacin+Ornidazole should not be taken with other antibiotics. Taking Ofloxacin+Ornidazole with other antibiotics can reduce its effectiveness. Speak to your doctor if you are taking other antibiotics.

Can Ofloxacin & Ornidazole treat eye infections?

Yes, Ofloxacin+Ornidazole can be used to treat certain types of eye infections. It is important to speak with your doctor or pharmacist to determine the cause of the eye infection before starting treatment with Ofloxacin+Ornidazole.

Does Ofloxacin & Ornidazole have any drug interactions?

Yes, Ofloxacin+Ornidazole can interact with certain other medications. Before taking Ofloxacin+Ornidazole, speak to your doctor or pharmacist if you are taking any other medications, including over-the-counter medications, vitamins or supplements.

How should Ofloxacin & Ornidazole be stored?

Ofloxacin+Ornidazole should be stored in a cool, dry place away from direct sunlight. Make sure to keep it out of the reach of children and pets.

What should I do if I take too much Ofloxacin+ Ornidazole?

If you believe you have taken too much Ofloxacin+Ornidazole, seek medical attention right away. Symptoms of an overdose may include stomach pain, nausea, vomiting, headache, confusion, and drowsiness.

What is the difference between Ofloxacin & Ornidazole and other antibiotics?

Ofloxacin+Ornidazole is a combination medication that contains both an antibiotic (ofloxacin) and an antiprotozoal/antibacterial agent (ornidazole). It is used to treat certain bacterial infections, including skin and soft tissue infections, bacterial vaginosis, and urinary tract infections. Other antibiotics can be used to treat different kinds of infections, such as respiratory infections, STD infections, and other bacterial infections.

What are the possible side effects of Ofloxacin & Ornidazole?

Common side effects of Ofloxacin+Ornidazole can include nausea, vomiting, upset stomach, headache, dizziness, diarrhea, and rash. More serious side effects are rare but can include fever, joint pain, yellowing of the skin and eyes, dark urine, and abdominal pain. If you experience any of these side effects, stop taking the medicine and speak to your doctor or pharmacist right away.

What is the dose of Ofloxacin & Ornidazole for children?

The recommended dose of Ofloxacin+Ornidazole for children is 500mg of ofloxacin and 500mg of ornidazole daily, or half of the adult dose. Speak with your doctor or pharmacist if you are unsure about the correct dosage.

What should I avoid while taking Ofloxacin & Ornidazole?

It is important to avoid drinking alcohol and taking any other medications, including OTC medications and supplements, while taking Ofloxacin+Ornidazole. Speak with your doctor or pharmacist before starting any other medications while taking Ofloxacin+Ornidazole.

When should I stop taking Ofloxacin & Ornidazole?

You should only stop taking Ofloxacin+Ornidazole after speaking to your doctor or pharmacist. It is important to take the full course of treatment to ensure the infection is completely treated. Do not stop taking the medication before the end of the prescribed course, even if you feel better.

Can I take Ofloxacin & Ornidazole while breastfeeding?

No, Ofloxacin+Ornidazole should not be taken by breastfeeding women. Speak to your doctor or pharmacist before taking any medication while breastfeeding.

https://www.medicinesfaq.com/brand/ofloxacin-ornidazole, ,