Notezine
Notezine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Notezine is a brand name. Its generic name is Diethylcarbamazine.
Overview
Notezine (DEC) is an anti-parasitic medication used to treat filarial worm infestations and infections caused by nematodes, mites, or ticks. DEC is also referred to as dithiocarbamate. It is classified as an avermectin/milbemycin. DEC is usually taken orally, although it can also be given topically or by injection. Common side effects associated with DEC include nausea, vomiting, dizziness, and mild headaches.
Uses
DEC is typically used to treat filarial worm infestations, such as those caused by Wuchereria bancrofti and Brugia malayi. It is also used to treat infections caused by nematodes, mites, and ticks.
Mechanism of Action
DEC works by interfering with parasite larvae and adult worm metabolism, causing worms to become paralyzed. This results in its death and eventual destruction of the parasite. It can also help to reduce the damage caused by the worms to infected tissues.
How Long Does It Take To Work?
The exact time it takes for DEC to work in treating filarial worm infestations varies from patient to patient, as well as to the organism being treated. Generally, it can take up to several weeks before symptoms improve.
Absorption
DEC is readily and completely absorbed from the gastrointestinal tract after oral administration. The plasma peak occurs about 45 minutes after administration.
Route of Elimination
DEC is rapidly and extensively metabolized in the liver and the metabolites are excreted in the feces.
Dosage
The dose of DEC depends on the type of parasite being treated and the patient's age, weight, and other factors. Generally, the standard adult dose for filariasis is 200 mg orally, three times daily for 4 days. The standard dose for nematode infections is 200 mg orally, once a day for 21 days.
Administration
DEC can be given orally, topically, or by injection. Oral administration is the most common route of administration.
Side Effects
Common side effects associated with DEC include mild headaches, nausea, vomiting, and dizziness. Rarely, more serious side effects can occur, such as difficulty breathing, rashes and itching, angioneurotic edema, and anaphylaxis.
Toxicity
The toxic dose of DEC is unknown. Symptoms of an overdose may include nausea, vomiting, abdominal pain, dizziness, fatigue, shortness of breath, and confusion.
Precautions and Warnings
DEC should not be used in patients with a history of hypersensitivity to the drug or any of its components. It is also not recommended in patients with hepatic impairment, as it may cause further liver damage. Patients should be closely monitored, and proper precautions should be taken to avoid overdose.
Interactions
DEC can interact with other medications, including antibiotics and antifungal agents. Therefore, it is important to tell your doctor about all medications you are taking, before starting treatment with DEC.
Drug Interaction
DEC may interact with certain medications, including antibiotics and antifungal agents. It is important to tell your doctor about all medications you are taking, before starting treatment with DEC.
Food Interactions
DEC is not known to interact with food or drinks. It is recommended to take it with water or other liquids. Avoid ingesting alcohol while taking DEC.
Pregnancy Use
DEC is not recommended for use during pregnancy, due to the lack of data on its safety and efficacy.
Lactation Use
DEC is not recommended for use during lactation, due to the lack of data on its safety and efficacy.
Acute Overdose
An acute overdose of DEC can cause nausea, vomiting, abdominal pain, dizziness, fatigue, shortness of breath, confusion, and other symptoms. Prompt medical attention should be sought if an overdose is suspected.
Contraindication
DEC should not be used in patients with a history of hypersensitivity to the drug or any of its components. It should also not be used in patients who are pregnant or breastfeeding, as it is not known to be safe or effective.
Use Direction
It is important to follow the instructions provided by your healthcare provider when taking DEC. The dose and duration of therapy depend on the type of infestation or infection being treated and the patient's age, weight, and other factors.
Storage Condition
DEC should be stored in a cool, dry place away from direct sunlight and moisture. Keep this and all medication out of reach of children.
Volume of Distribution
The volume of distribution of DEC in the body is approximately 0.8-1.4 L/kg.
Half Life
The elimination half-life of DEC is approximately 2-4 hours.
Clearance
The clearance of DEC is approximately 25-40 mL/min/kg.
Here you find in details version of Notezine
Some Frequently Asked Questions About Notezine
What is Notezine?
Notezine (DEC) is an orally administered drug that is used to treat filariasis (also known as elephantiasis) caused by infection with threadworm. It is also sometimes used to treat some other parasitic worm infections.
What is the dosage of Notezine?
The recommended dosage of diethylcarbamazine is 6mg/kg of body weight for adults and 10mg/kg for children. For children, the dose may be divided into two parts, with one half taken in the morning and the other half taken in the evening.
What is Notezine used for?
Notezine is used to treat filariasis (also known as elephantiasis) caused by infection with threadworm. It is also sometimes used to treat some other parasitic worm infections.
How does Notezine work?
Notezine works by paralyzing and killing the parasites that cause filariasis. It also blocks the transmission of the infection from one person to another.
How long does it take for Notezine to work?
It typically takes 1-3 days for Notezine to start working. It may take a few weeks or months to see the full effects of the medication.
What are the side effects of Notezine?
Common side effects of Notezine include nausea, vomiting, dizziness, headache, itching, and skin rash. Serious side effects include liver or kidney damage, anemia, and seizures. Call your doctor if you experience any of these symptoms.
Does Notezine interact with any other medications?
Yes, Notezine can interact with other medications, including anticonvulsants, antibiotics, immunosuppressants, and antifungals. Be sure to tell your doctor about all the medications that you are taking before starting Notezine.
Does Notezine cause birth defects?
Notezine is not known to cause birth defects. However, as with any medication, it is important to talk to your doctor before taking Notezine if you are pregnant or planning to become pregnant.
Is Notezine available over the counter?
No, Notezine is not available over the counter and must be prescribed by a doctor.
Can I take Notezine long-term?
Yes, you can take Notezine long-term if it is prescribed by your doctor. However, you should always follow your doctor’s instructions.
How should I store Notezine?
Notezine should be stored at room temperature and away from light and moisture. Do not store the medication in the bathroom. Keep Notezine in a secure place out of the reach of children and pets.
What should I do if I miss a dose of Notezine?
If you miss a dose of Notezine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed dose.
Can children take Notezine?
Yes, children can take Notezine. The usual dosage is 10mg/kg of body weight. The dose may be divided into two parts, with one half taken in the morning and the other half taken in the evening.
Does Notezine cause liver damage?
Yes, Notezine can cause liver damage. It is important to monitor your liver function while taking this medication and to call your doctor immediately if you experience any symptoms of liver damage, such as yellowing of the skin or eyes, dark urine, abdominal pain, or tiredness.
Can I drink alcohol with Notezine?
No, you should not drink alcohol while taking Notezine. Drinking alcohol can increase your risk of experiencing side effects from the medication, such as stomach irritation, nausea, dizziness, and drowsiness.
Will Notezine cure my infection?
It depends on the type of infection you have. Notezine is used to treat filariasis (also known as elephantiasis) caused by infection with threadworm. It is also sometimes used to treat some other parasitic worm infections. Be sure to talk to your doctor to find out if it is the right medication for your infection.
What if I am allergic to Notezine?
If you are allergic to Notezine, you should not take it. Instead, talk to your doctor about other treatment options that might be more suitable for you. Some people experience serious allergic reactions to Notezine, so it is important to tell your doctor if you have had an allergic reaction to this medication in the past.
Is Notezine safe for pregnant women?
It is not recommended that pregnant women take Notezine. There is insufficient data available about the safety of this medication during pregnancy, so be sure to talk with your doctor before taking it.
What should I do if I experience side effects while taking Notezine?
If you experience any side effects while taking Notezine, you should talk to your doctor immediately. Serious side effects include liver or kidney damage, anemia, and seizures.
Can I drive while taking Notezine?
You should not drive while taking Notezine, since the medication can cause drowsiness and dizziness. It is best to avoid any potentially hazardous activities such as driving while taking this medication.
Can I take Notezine with other medications?
Yes, you can take Diethylcarb