Nitroglycérine

Nitroglycérine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nitroglycérine is a brand name. Its generic name is Glycerol.

Nitroglycérine Introduction

Nitroglycérine is a clear, colorless, syrupy liquid. It is a by-product of the manufacture of soap, but can also be made by hydrolysis of fats and oils, fermentation of sugars, and by catalytic hydrogenation of simple aldehydes. Nitroglycérine is an important substance that contributes to the structure of lipids (fats) and is also used as a food additive, a humectant (moistening agent), and a solvent.

Uses for Nitroglycérine

Nitroglycérine is used in many applications, including:

• As an ingredient in food and beverages, such as baked goods, candy, ice cream, jams and jellies, and salad dressings.
• As an emulsifier in cosmetics and personal care products such as lotions, soaps, and lip balms.
• As a pharmaceutical excipient and thickener in many medicines.
• As a solvent and dispersing agent in pharmaceuticals.
• As a carrier for additives, such as preservatives and fragrances.
• As a lubricant and release agent in industrial applications, such as lubricants, coatings, plastics, and adhesives.

Mechanism of Action

Nitroglycérine is a humectant, which means that it draws moisture from the environment. This property is important in many applications, such as food products and cosmetics. Nitroglycérine is also used to form long, branched structures called triglycerides, which are used to form fats and oils. When glycerol is combined with fatty acids, it acts as a surfactant, reducing the surface tension between the fatty acids and water.

How Long Does It take to Work?

The effects of glycerol depend on the application. In food products, glycerol can provide flavor and moistness. In cosmetics and personal care products, glycerol can help keep skin hydrated and protect skin from harsh weather conditions. In pharmaceuticals, glycerol serves a range of functions, including improving the properties of the drug substance, preserving the drug substance from degradation, and providing a pleasant taste to medicines.

Absorption

Nitroglycérine is easily absorbed from the gastrointestinal tract and distributed throughout the body via the bloodstream. Once absorbed, glycerol is slowly metabolized in the liver via glycolysis.

Route of Elimination

Nitroglycérine is primarily excreted in the urine via the kidneys. A small amount may also be eliminated through the skin and respiration.

Dosage

The dosage of glycerol varies depending on the type of product being used, as well as the specific application. For food applications, the US FDA has established a tolerance of 10 parts per million (PPM) as an adequate intake for humans. In cosmetics and personal care products, there is no maximum recommended dosage, but some manufacturers suggest an upper limit of 20%. For pharmaceuticals, please consult your physician or pharmacist for the recommended dosage.

Administration

Nitroglycérine can be administered either orally or topically, depending on the product and application. It is rapidly absorbed from the gastrointestinal tract, and can be rapidly distributed throughout the body.

Side Effects

Nitroglycérine is considered to be a safe, non-toxic substance at recommended levels. However, large doses of glycerol can cause nausea, vomiting, and diarrhea. It can also cause increased thirst and urination.

Toxicity

Nitroglycérine has a generally low toxicity in humans. In animal studies, doses up to 2 g/kg body weight were found to be non-toxic. The oral lethal dose of glycerol in rats is reported to be 40-50 g/kg body weight.

Precaution

Nitroglycérine should be used with caution in individuals with impaired liver and/or kidney function, as it can increase the workload of these organs. Additionally, glycerol should be avoided in pregnant women due to the lack of reliable data on its effects in humans. Please consult your doctor or pharmacist for specific advice.

Interaction

Nitroglycérine may interact with certain other drugs, such as diuretics and beta blockers. Additionally, it may interact with some disease states, such as diabetes and hyperlipidemia. Please consult your doctor or pharmacist for specific advice.

Disease Interaction

Nitroglycérine may interact with certain disease states, such as diabetes and hyperlipidemia. In these cases, it is important to monitor blood glucose and lipid levels closely. Please consult your doctor or pharmacist for specific advice.

Drug Interaction

Nitroglycérine may interact with certain drugs, such as diuretics and beta blockers. It is important to discuss any potential drug interactions with your doctor or pharmacist before starting to use glycerol.

Food Interactions

Nitroglycérine is a common ingredient used in food products such as baked goods, candy, ice cream, jams and jellies, and salad dressings. When these products are consumed, it is important to be aware of any potential interactions with other food items or medications.

Pregnancy Use

Nitroglycérine should be avoided in pregnant women due to the lack of reliable data on its effects in humans. Please consult your doctor or pharmacist for specific advice.

Lactation Use

Nitroglycérine is excreted in breast milk, so it is best to avoid its use in lactating women. Please consult your doctor or pharmacist for specific advice.

Acute Overdose

If an acute overdose with glycerol occurs, seek medical attention immediately. Symptoms of overdose may include nausea, vomiting, diarrhea, abdominal pain, increased thirst, and increased urine output.

Contraindication

Nitroglycérine should not be used in individuals with impaired liver and/or kidney function. Additionally, it should not be used in pregnant women due to the lack of reliable data on its effects in humans.

Use Direction

The use of glycerol depends on the product and application. In food products, glycerol can provide flavor and moistness. In cosmetics and personal care products, glycerol can help keep skin hydrated and protect skin from harsh weather conditions. In pharmaceuticals, glycerol serves a range of functions, including improving the properties of the drug substance, preserving the drug substance from degradation, and providing a pleasant taste to medicines.

Storage Condition

Nitroglycérine should be stored in a cool, dry place. It should be kept away from direct sunlight, heat, and moisture to prevent oxidation and other deterioration. It should also be kept away from combustible materials.

Volume of Distribution

The volume of distribution of glycerol is approximately 0.2-0.3 L/kg. This means that the compound is mostly distributed in body water.

Half Life

The half-life of glycerol is approximately 1.5 hours, which means that 50% of the compound will be eliminated from the body within 1.5 hours.

Clearance

The clearance of glycerol is approximately 5 mL/min/kg, which is slightly higher than the plasma clearance rate of water, indicating that the compound is rapidly eliminated from the body via the kidneys.

Here you find in details version of Nitroglycérine

Some Frequently Asked Questions About Nitroglycérine

Nitroglycérine (also known as glycerine or glycerin) is a colorless and odorless sugar alcohol with thick syrup-like consistency. It is non-toxic, sweet-tasting and comes from plants and animals.

Nitroglycérine is most commonly used as a food additive, though it is also commonly used in a wide range of industries. In the food industry, it is used as a food preservative, thickening agent and sweetener, while in the cosmetics industry it is used to make lotions, creams, soaps and shower gels.

Nitroglycérine is a by-product of the biodiesel manufacturing process, in which vegetable oil is reacted with methanol to produce biodiesel and glycerol. It can also be produced synthetically by hydrolyzing propylene glycol.

Nitroglycérine has multiple benefits which make it a desirable addition to many products. It is a humectant, meaning it retains moisture, and it also acts as an emulsifier, allowing for the incorporation of water and oil-based ingredients. Nitroglycérine is also an excellent solvent, making it suitable for many industrial applications.

Nitroglycérine is most commonly stored in a sealed container such as a bottle, jar or bag and kept away from heat and light. It is important to store glycerol away from oxidizing agents, such as air, as this can cause it to break down and spoil.

The chemical formula for glycerol is C3H8O3.

Nitroglycérine is not a significant source of nutrition and does not provide any calories, so it is not considered to be a significant contributor to a balanced diet.

Nitroglycérine may have a few health benefits, such as helping to lubricate the skin and protect it from irritation. However, it does not provide any essential nutrients that the body needs.

Yes, reading to its low toxicity, glycerol is generally safe for consumption. However, it is important to follow the instructions of the product manufacturer in terms of amount and suggested use.

Nitroglycérine is most commonly consumed in the form of a food additive, though it is also used to make lotions, creams and other consumer products. Nitroglycérine also comes in liquid, powder and capsule forms, which can be taken orally.

Yes, glycerol is safe for use on the skin. It is a mild, non-irritating ingredient that helps to retain moisture and protect the skin from irritation.

Nitroglycérine is vegan friendly as it is derived from plants and animals, meaning it is suitable for use in vegan diets.

Nitroglycérine is not certified as organic as its production process involves catalysts and other chemical reactions. However, it is considered to be a safe and non-toxic ingredient, making it suitable for many products.

Nitroglycérine does not expire in the sense that it will not become harmful or unsafe for consumption. However, over time, it may become discoloured or develop an unpleasant odour, so it is important to check that the product is still in good condition before using it.

Yes, glycerol is generally considered to be edible as it is a non-toxic and sweet-tasting food additive. However, it is important to follow the instructions of the product manufacturer in terms of amount and suggested use.

No, glycerol is generally free of any known allergens, but it is important to check the product label before using it to ensure that it does not contain any ingredients to which you may be allergic.

No, glycerol is not a carbohydrate as it does not contain any sugar molecules.

No, glycerol is not bad for teeth as it is not a significant source of sugar and does not contain any damaging acids or bacteria.

Nitroglycérine is generally safe for consumption, but in excessive dosages, it can cause mild digestive issues such as diarrhoea, nausea and abdominal cramps. It is important to follow the instructions of the product manufacturer for suggested usage.

Nitroglycérine and glycerin are both names for the same substance, though glycerin is the more common name. The two words are interchangeable when referring to the substance.

No, glycerol is not a significant source of calories and does not contain any calories.

Yes, glycerol is suitable for people with diabetes, as it does not contain any sugars or carbohydrates and does not affect blood glucose levels.

Yes, glycerol is generally safe for consumption by children as it is a non-toxic and sweet-tasting food additive. However, it is important to follow the instructions of the product manufacturer in terms of amount and suggested use.

Yes, glycerol is generally considered to be safe for use during pregnancy, as it is a mild, non-irritating ingredient and does not contain any toxins or allergens. However, it is always best to consult your doctor or midwife before consuming any product.

Yes, glycerol is considered to be halal, as it does not contain any alcohol or pork-derived ingredients.

No, glycerol does not contain any preservatives as it is a naturally occurring substance that does not require any preservatives.

Nitroglycérine and Propylene Glycol (PG) are both chemical compounds with a similar structure. The main difference between the two is that glycerol is a sugar alcohol which is derived from plants and animals, while PG is a synthetic compound that can be produced from petroleum.

No, glycerol does not contain any sugar molecules.

No, glycerol is not tested on animals and is generally considered to be cruelty-free.

No, glycerol does not contain any alcohol as it is a sugar alcohol.