Nipride
Nipride Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nipride is a brand name. Its generic name is Sodium Nitroprusside Dihydrate.
Introduction
Nipride is an unbranded prescription medication used to reduce high levels of blood pressure in adults and children. It works by helping to relax the muscles of the blood vessels, thus allowing increased blood flow and reducing high blood pressure.Uses
Nipride is usually used to treat severe or life-threatening cases of hypertension (high blood pressure). It is also sometimes used to relieve symptoms of heart failure or angina (chest pain).Mechanism of Action
Nipride belongs to a class of medications known as vasodilators. It works by relaxing the muscles of the blood vessels, thus allowing increased blood flow and reducing high blood pressure.How Long Does it Take to Work?
Nipride typically takes effect within a few minutes of being injected into the bloodstream. However, the effect of this medication can last for up to 4 hours.Absorption
Nipride is rapidly absorbed into the bloodstream following injection.Route of Elimination
The major route of elimination of Nipride is urine via glomerular filtration.Dosage
Nipride is typically administered as intravenous injection. The dose of Nipride varies depending on the severity of the condition. Usually it is started at a low dose of 0.3 mg/kg/minute (up to 10 mg/minute) and may be increased slowly until the desired effect is achieved. The maximum dose should not exceed 30 mg/minute.Administration
Nipride is usually administered as an intravenous injection. The injection should be given slowly and continuously in a controlled drip over a period of several minutes, usually 2 to 4 minutes.Side Effects
The most common side effects of Nipride include headache, lightheadedness, nausea, flushing, and dizziness. It can also cause low blood pressure, tachycardia (rapid heart rate), and hypotension (low blood pressure).Toxicity
The toxic effects of Nipride include increased bleeding, decreased urine production, impaired liver function, and seizures. It can also cause serious allergic reactions such as anaphylaxis in some people.Precautions
Before using Nipride, it is important to tell your healthcare provider about all of your medical conditions (e.g., heart disease, kidney disease, liver disease, diabetes, etc.). In addition, tell your healthcare provider if you are pregnant or breastfeeding.Interactions
Nipride may interact with other medications, including diuretics, steroids, angiotensin-converting enzyme inhibitors, beta blockers, nitroglycerin, thiazide diuretics, calcium channel blockers, and phosphodiesterase type-5 inhibitors. It is important to tell your healthcare provider about all medications you are taking, including over-the-counter medications, supplements, and vitamins.Disease Interactions
Nipride should be used with caution in people with certain medical conditions such as heart disease, kidney disease, liver disease, diabetes, and low blood pressure.Drug Interactions
Nipride may interact with other medications that are taken orally or injected, including diuretics, steroids, angiotensin-converting enzyme inhibitors, beta blockers, nitroglycerin, thiazide diuretics, calcium channel blockers, and phosphodiesterase type-5 inhibitors. It is important to tell your healthcare provider about all medications you are taking, including over-the-counter medications, supplements, and vitamins.Food Interactions
There are no known food interactions with Nipride.Pregnancy Use
Nipride is not recommended for use in pregnant women.Lactation Use
It is not known whether Nipride passes into breast milk. Therefore, it is not recommended for use in breastfeeding women.Acute Overdose
The symptoms of an acute overdose of Nipride include reduced urine production, headache, nausea, flushing, dizziness, lightheadedness, hypotension, tachycardia, and seizures.Contraindications
Nipride is contraindicated in people with severe anemia, severe hypotension, septic shock, and hypersensitivity to the medication.Use Directions
Nipride should be used exactly as prescribed by your healthcare provider. The injection should be given slowly and continuously in a controlled drip over a period of several minutes, usually 2 to 4 minutes.Storage Conditions
Nipride should be stored at room temperature, away from light and moisture.Volume of Distribution
The volume of distribution of Nipride is approximately 0.3 L/kg.Half-Life
The average half-life of Nipride is approximately 3 minutes.Clearance
The clearance of Nipride is approximately 0.6 mL/minute/kg.Here you find in details version of Nipride