Nexletol
Nexletol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nexletol is a brand name. Its generic name is Bempedoic acid.
Bempedoic Acid Introduction
Nexletol is a cholesterol-lowering medication approved for adults with primary hyperlipidemia (high cholesterol levels in the blood) or mixed dyslipidemia (a combination of high triglycerides and low HDL cholesterol). It works by reducing the amount of cholesterol-producing enzymes in the liver.
Uses for
Nexletol is used to lower high cholesterol levels. It is used in combination with lifestyle changes including diet, exercise and weight loss.
Mechanism of Action
Nexletol is a cholesterol-lowering medication approved for adults with primary hyperlipidemia (high cholesterol levels in the blood) or mixed dyslipidemia (a combination of high triglycerides and low HDL cholesterol). It works by reducing the amount of cholesterol-producing enzymes in the liver. This results in lower levels of cholesterol in the blood.
How Long Does it Take to Work
Nexletol generally starts to lower cholesterol levels within 4 weeks after it is taken. It reaches its maximum effectiveness after 12 weeks of use. People with high cholesterol levels should continue to take the medication as prescribed by their doctor.
Absorption
Nexletol is rapidly absorbed after oral administration. Approximately 70-80% of the medication is absorbed into the bloodstream and the medication is metabolized by the liver.
Route of Elimination
Nexletol is eliminated from the body primarily via the kidneys, with a small amount being eliminated through the feces. It has a half-life of approximately 34-44 hours.
Dosage
The recommended starting dose of bempedoic acid is 180 mg, taken once daily either with or without food. The dose may be adjusted up to a maximum of 360 mg a day depending on the patient's response and tolerability.
Administration
Nexletol should be taken once daily, with or without food. It is important to take the medication exactly as prescribed by the doctor. It is also important to inform the doctor if the patient has any other medical conditions that may affect the dosage and efficacy of the medication.
Side Effects
The most common side effects of bempedoic acid include headache, nausea, muscle pain and weakness, constipation, and joint pain. These side effects are usually mild and do not require medical attention. In rare cases, serious side effects may occur which require immediate medical attention. These include loss of appetite, stomach pain, dark urine, blisters on the skin, jaundice, and severe allergic reaction.
Toxicity
Nexletol is generally well tolerated at the recommended dosage. Overdose may lead to increased side effects or serious toxicity. In the event of an overdose, it is important to seek medical attention immediately.
Precautions
Before taking bempedoic acid, it is important to consult a doctor for a full risk assessment to determine if it is the right medication for the patient. People with kidney or liver disease, as well as pregnant or nursing women, should not take bempedoic acid. It is important to inform the doctor if the patient is taking any other medications, as some medications may interact with bempedoic acid.
Interactions
Nexletol may interact with other medications including anti-inflammatory medications, cholesterol-lowering medications, beta-blockers, calcium channel blockers, and statins. It is important to tell the doctor about other medications the patient is taking, as well as any supplements or natural health products, in order to ensure a safe and effective treatment.
Disease Interactions
Nexletol should not be used in patients with kidney or liver disease, or those taking medications that might affect kidney or liver function. It is not recommended for use in patients who have had an organ transplant. It is also not recommended for use in pregnant or nursing women.
Drug Interactions
Nexletol may interact with certain other medications, including anti-inflammatory medications, cholesterol-lowering medications, beta-blockers, calcium channel blockers, and statins. It is important to tell the doctor about other medications the patient is taking, as well as any supplements or natural health products, in order to ensure a safe and effective treatment.
Food Interactions
Nexletol should not be taken with grapefruit or grapefruit juice due to potential interactions. It is also important to discuss dietary changes with a doctor before taking bempedoic acid. Some foods can interact with the medication and reduce its effectiveness.
Pregnancy Use
Nexletol is not recommended for use in pregnant or nursing women. It is important to consult a doctor before taking any medication during pregnancy or while breastfeeding.
Lactation Use
Nexletol is not recommended for use in nursing women. It is important to consult a doctor before taking any medication while breastfeeding.
Acute Overdose
If an overdose of bempedoic acid is suspected, it is important to seek medical attention immediately. Symptoms of an overdose may include headache, nausea, muscle pain and weakness, constipation, and joint pain.
Contraindication
Nexletol should not be used in patients with kidney or liver disease, or those taking medications that might affect kidney or liver function. It is also contraindicated in pregnant or nursing women. It is important to tell the doctor about other medications the patient is taking, as some medications may interact with bempedoic acid.
Use Direction
Nexletol is usually taken once a day with or without food. It is important to take the medication exactly as prescribed by the doctor. It is also important to inform the doctor if the patient has any other medical conditions that may affect the dosage or efficacy of the medication.
Storage Condition
Nexletol should be stored at room temperature, away from moisture and heat. It should be kept out of reach of children and pets.
Volume of Distribution
The volume of distribution of bempedoic acid is approximately 17-18 L, which suggests that the drug is largely distributed in the body.
Half Life
The half-life of bempedoic acid is approximately 34-44 hours, meaning that it is slowly eliminated from the body.
Clearance
The clearance of bempedoic acid is approximately 7-8 L/h, indicating that it is slowly eliminated from the body.
Here you find in details version of Nexletol