Neugrastim

Neugrastim Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Neugrastim is a brand name. Its generic name is Filgrastim.

Neugrastim

Neugrastim is a biosynthetic form of human granulocyte colony-stimulating factor (G-CSF). It is used to treat a variety of chronic and acute hematologic conditions, including malignancies, myelodysplastic syndromes, and immunodeficiencies. In malignancies, it is used to increase blood cell counts in patients undergoing chemotherapy and to prevent neutropenia (low levels of neutrophils). Neugrastim is also used to increase the number of stem cells collected from the patient's bone marrow for autologous transplantation.

Uses

Neugrastim is used to treat neutropenia caused by a variety of conditions, including chemotherapy, radiation therapy, bone marrow transplantation, and some immunologic disorders. It is also used to increase the number of stem cells collected from the bone marrow for autologous transplantation, and to reduce the risk of infection in patients with HIV/AIDS.

Mechanism of Action

Neugrastim stimulates the production of neutrophils (white blood cells) in the bone marrow. It binds to the membrane-bound receptor G-CSFR, which activates the JAK/STAT pathway to induce the production of neutrophils. It also promotes the release of neutrophils from the bone marrow into the bloodstream.

How Long Does It Take to Work?

The effects of filgrastim can be seen within 24-48 hours, but it can take up to 2 weeks for the full effects of the drug to be seen. The peak effects of the drug occur 1-2 days after administration.

Absorption

Neugrastim is almost completely absorbed after subcutaneous or intramuscular administration. Peak concentrations are reached in 2-4 hours.

Route of Elimination

Neugrastim is primarily eliminated by the kidneys. Approximately 70-80% of the drug is excreted unchanged in the urine.

Dosage

The recommended dosage of filgrastim is 5 to 10 mcg per kilogram of body weight administered once a day. The dose can be adjusted up to a maximum of 30 mcg per kilogram depending on the patient’s response. The dosage should be given 1-2 days before chemotherapy or radiation therapy and continued until the patient’s blood cell count returns to normal.

Administration

Neugrastim can be administered by subcutaneous or intramuscular injection. The injection should be given in the upper arm, thigh, abdomen, or buttocks.

Side Effect

Common side effects of filgrastim include nausea, vomiting, bone pain, headache, muscle pain, and fatigue. Rare but serious side effects include bone marrow suppression, allergic reactions, and severe respiratory disorders.

Toxicity

Neugrastim is not known to be toxic, however long-term use of high doses of the drug can lead to bone marrow suppression.

Precaution

Neugrastim should be used with caution in patients with pre-existing hematologic disorders or in those with an increased risk of bleeding. It should not be used in patients with genetic defects in the interleukin-3 (IL-3) receptor alpha chain, and it should be used with caution in patients with renal impairment.

Interaction

There are no known drug or disease interactions with filgrastim.

Food Interactions

No food interactions with filgrastim are known.

Pregnancy Use

Neugrastim should be used during pregnancy only if absolutely necessary and only under the supervision of a healthcare provider.

Lactation Use

Neugrastim is not known to be excreted in breast milk and should not affect the nursing infant.

Acute Overdose

There is no specific antidote for an overdose of filgrastim and treatment is symptomatic and supportive. Intravenous fluids and electrolyte replacement may be necessary.

Contraindication

Neugrastim is contraindicated in patients with a known hypersensitivity to recombinant G-CSF or any of the components of the product.

Use Direction

Neugrastim should be administered by subcutaneous or intramuscular injection. The injection should be given in the upper arm, thigh, abdomen, or buttocks.

Storage Condition

Neugrastim should be stored at temperatures between 20° and 25°C. It should be protected from light and kept away from heat and moisture.

Volume of Distribution

After intravenous administration, the volume of distribution of filgrastim is approximately 3.7 liters per kilogram.

Half Life

The elimination half-life of filgrastim is approximately 3 hours.

Clearance

The total body clearance of filgrastim is approximately 26 liters per hour per kilogram.

Here you find in details version of Neugrastim

Some Frequently Asked Questions About Neugrastim

What is Neugrastim?

Neugrastim is an injectable biologic prescription medicine used to reduce the chance of infection in people with certain types of cancer and to reduce the risk of infection in people with Chronic Granulomatous Disease.

What is the active ingredient in Neugrastim?

The active ingredient in Neugrastim is recombinant human granulocyte-colony stimulating factor, which is a recombinant DNA-derived human protein.

How does Neugrastim work?

Neugrastim helps the body to produce more neutrophils, which are a type of white blood cell that fights infection. This helps to reduce the chance of infection in people with cancer or Chronic Granulomatous Disease (CGD).

What are some of the side effects of Neugrastim?

The most common side effects of Neugrastim include bone pain, injection site reactions, headache, and fatigue. Tell your doctor if you have any side effects.

How is Neugrastim given?

Neugrastim is given as a single injection under your skin. Your doctor will advise when and how to use it.

Who should not take Neugrastim?

Do not take Neugrastim if you are allergic to it, had a severe allergic or hypersensitivity reaction after receiving filgrastim in the past, or suffered from a splenic rupture before.

What is Neugrastim used for?

Neugrastim is used to reduce the chance of infection in people with certain types of cancer and to reduce the risk of infection in people with Chronic Granulomatous Disease (CGD).

What should I tell my healthcare provider before taking Neugrastim?

Tell your healthcare provider if you are pregnant, breastfeeding, have liver or kidney disease, or have any allergies.

What if I forget a dose of Neugrastim?

If you miss a dose of Neugrastim, contact your healthcare provider for advice on when to take your next dose.

Can Neugrastim be used during pregnancy?

Neugrastim should not be used during pregnancy unless clearly necessary. Talk to your doctor about any potential risks to your pregnancy.

Who should not take Neugrastim?

Do not take Neugrastim if you are allergic to it, had a severe allergic or hypersensitivity reaction after receiving filgrastim in the past, or suffered from a splenic rupture before.

What is the recommended dose of Neugrastim?

The recommended dose of Neugrastim is determined by your healthcare provider and depends on your age, body weight, and medical condition.

Are there any drug interactions with Neugrastim?

Yes, Neugrastim may interact with other medications such as anticoagulants, corticosteroids, and other immunosuppressants. Talk to your doctor or pharmacist about any potential drug interactions.

Does Neugrastim have any side effects?

The most common side effects of Neugrastim include bone pain, injection site reactions, headache, and fatigue. Tell your doctor if you have any side effects.

Can children take Neugrastim?

Yes, Neugrastim is approved for use in children two years of age and older. Talk to your doctor to determine if Neugrastim is right for your child.

What should I do if I experience any side effects from Neugrastim?

If you experience any side effects from Neugrastim, contact your doctor or healthcare provider immediately.

Can I take Neugrastim if I'm breastfeeding?

Neugrastim should not be taken while breastfeeding due to the risk of side effects in the infant. Talk to your doctor for more information.

Can Neugrastim be used for chronic granulomatous disease?

Yes, Neugrastim is used to reduce the risk of infection in people with Chronic Granulomatous Disease (CGD).

Are there any risks associated with taking Neugrastim?

Yes, there is a risk of serious side effects associated with taking Neugrastim, such as splenic rupture. Talk to your doctor or healthcare provider for more information.

What should I do if I miss a dose of Neugrastim?

If you miss a dose of Neugrastim, contact your healthcare provider for advice on when to take your next dose.

What should I avoid while taking Neugrastim?

You should avoid activities that may put you at risk of infection, such as contact sports or swimming in public pools.

Can I take other medications with Neugrastim?

You should tell your healthcare provider about all the medications you are taking, including prescription and non-prescription drugs, vitamins, and herbal supplements, as they may interact with Neugrastim.

Can I drive or operate machinery while taking Neugrastim?

You should avoid driving or operating machinery while taking Neugrastim, as it may cause side effects such as dizziness or fatigue.

What should I do if I experience any signs of infection while taking Neugrastim?

If you experience any signs of infection while taking Neugrastim, such as fever, chills, or sore throat, contact your doctor or healthcare provider immediately.

How long should I take Neugrastim?

The length of treatment with Neugrastim will depend on your individual needs and should be determined by your doctor.

Are there alternative treatments for reducing infection risk?

Yes, other treatments such as antibiotics or immune-modulating drugs may be used to reduce infection risk.

How should I store Neugrastim?

Neugrastim should be stored in a refrigerator at 2°C – 8°C (36°F – 46°F). Keep out of reach of children and away from heat and light.

Can I take Neugrastim if I have liver or kidney disease?

Talk to your doctor before taking Neugrastim if you have liver or kidney disease. Your doctor may adjust your dose or recommend an alternative treatment.

Will Neugrastim affect my fertility?

Neugrastim has been known to affect fertility in animal studies. Talk to your doctor if you are concerned about a possible effect on your fertility.

Should I avoid certain activities while taking Neugrastim?

You should avoid contact sports and activities that may put you at risk of infection while taking Neugrastim.

What other drugs are similar to Neugrastim?

Other drugs similar to Neugrastim include pegfilgrastim and biosimilars. Talk to your doctor or pharmacist about the differences between these drugs.

Can Neugrastim be used to treat cancer?

No, Neugrastim is used to reduce the chance of infection in people with certain types of cancer and to reduce the risk of infection in people with Chronic Granulomatous Disease (CGD).

What if I overdose on Neugrastim?

If you have overdosed on Neugrastim, contact your healthcare provider or poison control center right away.

Are there any food restrictions while taking Neugrastim?

No, there are no food restrictions while taking Neugrastim.

How long does Neugrastim stay in the body?

Neugrastim typically stays in the body for about 24 hours.

Is there a generic version of Neugrastim available?

Yes, there is a generic version of Neugrastim available.

What happens if I take too much Neugrastim?

If you take too much Neugrastim, contact your doctor or healthcare provider right away.

Can Neugrastim be used to reduce the risk of infection in the elderly?

Yes, Neugrastim can be used to reduce the risk of infection in the elderly.

Can I use Neugrastim if I'm allergic to other drugs?

You should tell your healthcare provider about any allergies you may have in order to determine if Neugrastim is safe for you to use.

Can I drink alcohol while taking Neugrastim?

It is best to avoid drinking alcohol while taking Neugrastim. Talk to your doctor for more information.

Can Neugrastim cause weight gain?

Weight gain has been reported in people taking Neugrastim; however, it is not known if this is due to the drug itself or to other factors such as diet or lifestyle changes.

What should I do if I have an allergic reaction to Neugrastim?

If you have an allergic reaction to Neugrastim, stop taking it and contact your doctor or healthcare provider right away.

Is Neugrastim covered by insurance?

Neugrastim may be covered by some insurance plans. Check with your insurance provider to see if Neugrastim is covered.

When will I start to notice an effect from taking Neugrastim?

The effect of Neugrastim will depend on your individual needs and should be determined by your doctor. Talk to your doctor for more information.