Nebilol H
Nebilol H Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Nebilol H is a brand name. Its generic name is Nebivolol + Hydrochlorothiazide.
Introduction
Nebivolol and hydrochlorothiazide is a prescription drug combination used to treat high blood pressure and other heart problems. The active ingredients in this medication are nebivolol, an β1-selective adrenoceptor blocker, and hydrochlorothiazide, a diuretic that removes excess fluids from the body and prevents fluid retention.Uses For
Nebivolol and hydrochlorothiazide are mainly used to treat hypertension (high blood pressure) and edema (water retention). It can also help reduce the risk of stroke, heart attack, or kidney failure associated with high blood pressure.Mechanism of Action
Nebivolol and hydrochlorothiazide works by relaxing the blood vessels to reduce blood pressure, and increasing the amount of urine to help the body eliminate fluids. Nebivolol works by blocking beta-adrenergic receptors, which are responsible for the production and release of norepinephrine. Norepinephrine constricts the blood vessels, and by blocking this, nebivolol helps dilate the vessels and reduce blood pressure. Hydrochlorothiazide works by blocking sodium and chloride transport across thiazide diuretic cellular membranes.How Long Does it take to Work?
The effects of nebivolol and hydrochlorothiazide can be seen within a few hours, but it may take up to 4 weeks for the full effects of the drug to be realized.Absorption
Nebivolol is almost completely absorbed from the gastrointestinal tract. Hydrochlorothiazide is not readily absorbed. Both drugs are metabolized in the liver and then eliminated by the kidneys.Route of Elimination
The active ingredients in nebivolol and hydrochlorothiazide are eliminated mainly through the kidneys.Dosage
The recommended dose for nebivolol and hydrochlorothiazide is one tablet taken once daily or as prescribed by a doctor. It is important to take this medication as directed and not to skip doses or take more than prescribed.Administration
Nebivolol and hydrochlorothiazide is usually taken orally once daily with or without food. It is important to take this medication as prescribed and to not change the dose without talking to your doctor.Side Effect
Common side effects of nebivolol and hydrochlorothiazide include dizziness, headache, nausea, vomiting, stomach pain, unusual tiredness, dry mouth, muscle cramps, and weakness. Contact a doctor if any of these side effects become intense or are prolonged.Toxicity
Nebivolol and hydrochlorothiazide is generally well tolerated, and the most common side effects are generally mild. If an overdose occurs, contact a poison control center or an emergency room immediately.Precaution
Patients should inform their doctor of any other medications being taken (prescription, non-prescription, herbal, or vitamins), as well as any medical conditions prior to taking nebivolol and hydrochlorothiazide. This medication should be used during pregnancy only when needed, and it should be used with caution during lactation.Interaction
Nebivolol and hydrochlorothiazide may interact with other medications or supplements being taken. Patients should talk to their doctor before taking any other medications while on this combination of drugs.Disease Interaction
Nebivolol and hydrochlorothiazide may not be safe for use in patients with certain conditions such as diabetes, heart disease, kidney or liver disease, or gout. Patients should discuss any existing medical conditions with their doctor prior to taking this medication.Drug Interaction
Nebivolol and hydrochlorothiazide may interact with certain medications. These include but are not limited to drugs like aliskiren, ACE inhibitors, diuretics, angiotensin receptor blockers, lithium, nonsteroidal anti-inflammatory drugs, and barbiturates.Food Interactions
It is generally recommended to avoid alcohol while taking this medication. Patients should also avoid eating grapefruit and grapefruit products while on this combination of drugs.Pregnancy Use
Nebivolol and hydrochlorothiazide should be used during pregnancy only when needed, and with caution. Patients should talk to their doctor about the risks of using this medication during pregnancy.LactationUse
Nebivolol and hydrochlorothiazide should be used during lactation with caution. Patients should discuss the risks of using this medication while breastfeeding with their doctor.Acute Overdose
If an overdose occurs, contact a poison control center or an emergency room immediately.Contraindication
Patients should not take nebivolol and hydrochlorothiazide if they have a history of allergic reaction to either drug, kidney disease, liver disease, gout, or asthma.Use Direction
Patients should take this medication exactly as prescribed by their doctor. The tablet should be taken orally, usually once daily with or without food. Do not take larger or more frequent doses than those recommended.Storage Condition
Store nebivolol and hydrochlorothiazide at room temperature, away from heat and moisture.Volume of Distribution
The volume of distribution of nebivolol and hydrochlorothiazide is unknown.Half Life
The half-life of nebivolol and hydrochlorothiazide is 12-18 hours.Clearance
The rate of clearance of nebivolol and hydrochlorothiazide is unknown.Here you find in details version of Nebilol H