Naproxène

Naproxène Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Naproxène is a brand name. Its generic name is Naproxen.

Introduction

Naproxène is a non-steroidal anti-inflammatory drug (NSAID) used to treat a wide range of painful conditions such as arthritis, migraine, muscle strain, and menstrual cramps.

Uses

Naproxène is used to temporarily relieve minor aches and pains due to arthritis, muscle strains, sprains, and bruises. It may also be used to temporarily reduce fever and to treat other conditions as determined by your healthcare provider.

Mechanism of Action

Naproxène works by blocking the production of prostaglandins, which are substances produced by the body that cause inflammation, pain and fever. By blocking the production of prostaglandins, naproxen is able to reduce inflammation, pain and fever.

How Long Does It Take To Work?

Naproxène usually starts to work within an hour after taking it, and most people will feel relief within four to six hours.

Absorption

Naproxène is readily absorbed from the gastrointestinal tract. Peak concentrations in plasma generally occur from 1 to 4 hours after an oral dose.

Route of Elimination

Naproxène is primarily metabolized by the liver and is then eliminated from the body through urine. Naproxène is not known to be excreted in breast milk.

Dosage

The usual adult dose of naproxen is 250 milligrams (mg) to 500 mg taken orally twice a day, with or after food. The maximum dose is 1,000 mg in a 24-hour period. For children 6 years and older, the recommended dose of naproxen is 7.5 mg per kilogram (3.4 mg per pound) of body weight per day, taken in 2 to 3 divided doses.

Administration

Naproxène should be taken by mouth as directed by your healthcare provider. It is important to take naproxen at the same time each day to avoid missing doses.

Side Effects

The most common side effects of naproxen are stomach upset, nausea, abdominal pain, indigestion, and headaches. Other less common side effects include ringing in the ears, dizziness, skin rash, hives, difficulty breathing, liver damage, and kidney damage.

Toxicity

Naproxène is generally considered to be a safe drug. Overdoses can cause serious medical problems, especially in older people, children, and people with medical conditions. Overdoses can cause nausea, vomiting, abdominal pain, drowsiness, seizures, and irregular heartbeats.

Precautions

Naproxène should not be used if you have active or past bleeding in the stomach or intestine, have elevated levels of uric acid, have a history of ulcers, have severe liver or kidney disease, have active or past bleeding problems, are pregnant or nursing, are taking warfarin or other anticoagulant medicines, or have a history of allergic reactions to aspirin or other NSAIDs.

Interactions

Naproxène can interact with other medications and supplements. Consult with your healthcare provider before taking any over-the-counter or prescription medications or supplements to ensure there will not be an interaction.

Disease Interactions

Naproxène is known to interact with certain medical diseases or conditions. Tell your healthcare provider about any medical diseases or conditions you may have before starting naproxen or any other medications.

Drug Interactions

Naproxène is known to interact with certain medications. Tell your healthcare provider about any medications or supplements you are taking, even if they are over-the-counter, to ensure there will not be an interaction.

Food Interactions

Naproxène should not be taken with alcohol. Additionally, grapefruit and grapefruit juice have the potential to interact with naproxen and should be avoided while taking this medication.

Pregnancy Use

Naproxène should be avoided in pregnant women and women who are planning to become pregnant. It should not be used during the first and third trimesters of pregnancy, when it has been associated with some birth defects.

Lactation Use

Naproxène should not be used by nursing mothers due to the potential for serious adverse effects in the nursing infant.

Acute Overdose

Acute overdose of naproxen can result in serious side effects such as drowsiness, seizures, coma, confusion, rapid heart rate, breathing problems, stomach upset, and vomiting. If you think you or someone else may have taken too much naproxen, seek emergency medical help right away.

Contraindication

Naproxène should not be used in people who have had a serious reaction to other NSAIDs, any allergies, or any active or past bleeding problems.

Use Directions

Naproxène should be taken exactly as directed by your healthcare provider. Do not take more or less than is prescribed and do not take it for a longer time than is recommended.

Storage Condition

Naproxène should be stored at room temperature, away from direct sunlight and heat. Keep out of the reach of children and pets.

Volume of Distribution

The volume of distribution of naproxen is approximately 0.6 liters per kilogram (L/kg).

Half Life

The half-life of naproxen is approximately 13 to 17 hours.

Clearance

The clearance of naproxen is approximately 0.2 liters per hour (L/hr).

Here you find in details version of Naproxène

Some Frequently Asked Questions About Naproxène

What is Naproxène?

Naproxène is a non-steroidal anti-inflammatory drug (NSAID) used to treat a variety of conditions like arthritis, tendinitis, bursitis, ankylosing spondylitis, and menstrual cramps.

How does Naproxène work?

Naproxène works by reducing hormones that cause inflammation and pain in the body. In addition, it may also block certain enzymes that are involved in the formation of pain-causing chemicals.

Who should not take Naproxène?

People who have had a recent heart attack, stroke, or bleeding in the stomach or intestines should not take Naproxène. Additionally, those with kidney or liver disease, bleeding disorders, or who are allergic to aspirin or other NSAIDs should not take this medication.

What are the possible side effects of Naproxène?

The most common side effects of Naproxène are nausea, heartburn, headache, dizziness, drowsiness, rashes, and swelling. It may also increase the risk of bleeding or ulcers in the stomach or intestines. In rare cases, taking Naproxène may lead to kidney or liver problems.

How is Naproxène taken?

Naproxène should be taken as directed by a healthcare provider. It is usually taken with food or milk in order to reduce stomach upset. It is generally taken one to three times daily, depending on the condition being treated.

What is the difference between Naproxène and Ibuprofen?

Naproxène and ibuprofen are similar NSAID pain medications. However, Naproxène is longer-acting and may be more effective in treating certain pain conditions. Talk to your doctor to determine which medication is best for you.

What is the recommended dose of Naproxène?

The recommended dose of Naproxène depends upon the condition being treated. Generally, for adults, the starting dose is 250-500 mg twice daily. It should be taken with food or milk to reduce stomach upset.

Can I take Naproxène with other medications?

Naproxène may interact with other medications, including aspirin and other NSAIDs, anticoagulants, steroids, and certain antibiotics. Talk to your doctor before taking any other medications along with Naproxène.

Is Naproxène safe for pregnant women?

Naproxène is not recommended for pregnant women unless directed by a healthcare professional. It is not known if Naproxène can harm the developing fetus. Naproxène should not be taken by breastfeeding women.

What should I do if I miss a dose of Naproxène?

If you miss a dose of Naproxène, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the next dose as scheduled.

What should I avoid while taking Naproxène?

Alcohol, caffeine, napping, or strenuous activity should be avoided while taking Naproxène. Additionally, do not take aspirin while taking Naproxène as it may increase the risk of bleeding and stomach ulcers.

What are the symptoms of an allergic reaction to Naproxène?

Symptoms of an allergic reaction to Naproxène may include a rash, hives, itching, difficulty breathing, tightness in the chest, or swelling of the mouth, face, lips, or tongue.

Can I take Naproxène if I have high blood pressure?

Naproxène may increase the risk of high blood pressure and should not be taken by people with existing high blood pressure unless directed by a healthcare professional.

Can I take Naproxène with other pain relief medications?

Naproxène may interact with other medications used for pain relief and should not be taken with aspirin, ibuprofen, or other NSAIDs without talking to your doctor first.

What are the long-term side effects of taking Naproxène?

Long-term use or excessive doses of Naproxène may increase the risk of developing kidney or liver problems, as well as heart attack, stroke, or bleeding in the stomach or intestines. Talk to your doctor if you have any concerns.

Is Naproxène addiction a concern?

Naproxène is not known to be habit-forming. However, it should not be taken for longer than recommended by your doctor.

Can I take Naproxène if I am over 65 years old?

Naproxène is generally safe for people over 65, although they may require a lower dose. Talk to your doctor to determine if Naproxène is safe for you.

How long does Naproxène take to work?

Naproxène usually begins to work within 1 to 2 hours of taking it. It may take up to 2 days to reach the maximum effect.

What should I do if I am taking Naproxène and experience stomach upset?

If you are experiencing stomach upset while taking Naproxène, try taking the medicine with food or milk. If the upset persists, talk to your doctor about other options.

Can taking Naproxène cause constipation?

Yes, taking Naproxène may cause constipation or indigestion. To help prevent constipation, increase your dietary fiber and drink plenty of fluids.

Can I take Naproxène if I am diabetic?

Naproxène may affect blood sugar levels, so it is important to monitor your blood sugar levels closely while taking this medication. Talk to your doctor if you have any concerns.

Is there an alternative to Naproxène?

Naproxène may be used as an alternative to other pain medications, such as ibuprofen or aspirin. Talk to your doctor to determine the best treatment for your condition.

Can children take Naproxène?

Naproxène is not recommended for children under 12 years old. Children 12 years and older may take Naproxène when directed by a healthcare professional.

Can I take Naproxène if I am on blood thinners?

Naproxène may increase the risk of bleeding and should not be taken by people taking blood thinners or other medications that may increase the risk of bleeding. Talk to your doctor about any medications you are taking.

Can taking Naproxène cause dizziness?

Yes, taking Naproxène may cause dizziness or drowsiness, which may affect your ability to drive or operate machinery. Talk to your doctor if you experience dizziness while taking Naproxène.

Can I take Naproxène if I am taking medication for high blood pressure?

Naproxène may increase the risk of high blood pressure and should not be taken by people with existing high blood pressure unless directed by a healthcare professional. Talk to your doctor about the risks and benefits of taking both medications.

Can I take Naproxène with antihistamines?

Yes, it is generally safe to take Naproxène with antihistamines, however it is important to note that they may interact with other medications. Always talk to your doctor before taking any medications together.

Can I take Naproxène with steroids?

Naproxène can interact with certain steroids and should not be taken with them unless directed by a healthcare professional. Talk to your doctor about any medications you are taking.

Can taking Naproxène cause elevated liver enzymes?

Yes, taking Naproxène for an extended period of time or in high doses may increase the risk of elevated liver enzymes. Talk to your doctor if you experience any signs or symptoms of liver problems.

Can I take an antacid while taking Naproxène?

Yes, it is generally safe to take antacids while taking Naproxène. However, it is important to note that antacids may interact with other medications. Always talk to your doctor before taking any medications together.

Can I take Naproxène if I have a history of GI problems?

Naproxène may increase the risk of developing stomach or intestinal irritation or bleeding and should not be taken by people with a history of GI problems unless directed by a healthcare professional.

Can taking Naproxène cause headaches?

Yes, headaches are a common side effect of taking Naproxène. If you are experiencing headaches while taking Naproxène, talk to your doctor about other options.

Can taking high doses of Naproxène cause kidney damage?

Taking high doses of Naproxène may increase the risk of developing kidney damage. Talk to your doctor about the risks and benefits of taking this medication.

Can I take Naproxène if I have asthma?

Naproxène may increase the risk of asthma attacks in some people and should not be taken by people with asthma unless directed by a healthcare professional.

What can I do if I experience nausea while taking Naproxène?

Taking Naproxène with food or milk may help reduce nausea. If the nausea persists, talk to your doctor about other options.

Is there a generic version of Naproxène?

Yes, there is a generic version of Naproxène available. Talk to your doctor or pharmacist about cost options for the generic version of this medication.

Can taking Naproxène cause elevated cholesterol levels?

Yes, taking Naproxène may increase the risk of elevated cholesterol levels. Talk to your doctor if you have any concerns.

Can I take Naproxène if I am taking a blood pressure medication?

Yes, it is generally safe to take Naproxène with blood pressure medications, however it is important to note that they may interact with other medications. Always talk to your doctor before taking any medications together.

Is Naproxène available over-the-counter?

Yes, Naproxène is available in some states over-the-counter. Always read the label and talk to your doctor or pharmacist before taking any medication.

Is there a natural alternative to Naproxène?

Yes, some people find relief with natural alternatives such as acupuncture, yoga, massage, and heat or cold therapy. Talk to your doctor to determine the best treatment for your condition.