Naproxen

Naproxen Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Naproxen is a brand name. Its generic name is Naproxen.

Introduction

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) used to treat a wide range of painful conditions such as arthritis, migraine, muscle strain, and menstrual cramps.

Uses

Naproxen is used to temporarily relieve minor aches and pains due to arthritis, muscle strains, sprains, and bruises. It may also be used to temporarily reduce fever and to treat other conditions as determined by your healthcare provider.

Mechanism of Action

Naproxen works by blocking the production of prostaglandins, which are substances produced by the body that cause inflammation, pain and fever. By blocking the production of prostaglandins, naproxen is able to reduce inflammation, pain and fever.

How Long Does It Take To Work?

Naproxen usually starts to work within an hour after taking it, and most people will feel relief within four to six hours.

Absorption

Naproxen is readily absorbed from the gastrointestinal tract. Peak concentrations in plasma generally occur from 1 to 4 hours after an oral dose.

Route of Elimination

Naproxen is primarily metabolized by the liver and is then eliminated from the body through urine. Naproxen is not known to be excreted in breast milk.

Dosage

The usual adult dose of naproxen is 250 milligrams (mg) to 500 mg taken orally twice a day, with or after food. The maximum dose is 1,000 mg in a 24-hour period. For children 6 years and older, the recommended dose of naproxen is 7.5 mg per kilogram (3.4 mg per pound) of body weight per day, taken in 2 to 3 divided doses.

Administration

Naproxen should be taken by mouth as directed by your healthcare provider. It is important to take naproxen at the same time each day to avoid missing doses.

Side Effects

The most common side effects of naproxen are stomach upset, nausea, abdominal pain, indigestion, and headaches. Other less common side effects include ringing in the ears, dizziness, skin rash, hives, difficulty breathing, liver damage, and kidney damage.

Toxicity

Naproxen is generally considered to be a safe drug. Overdoses can cause serious medical problems, especially in older people, children, and people with medical conditions. Overdoses can cause nausea, vomiting, abdominal pain, drowsiness, seizures, and irregular heartbeats.

Precautions

Naproxen should not be used if you have active or past bleeding in the stomach or intestine, have elevated levels of uric acid, have a history of ulcers, have severe liver or kidney disease, have active or past bleeding problems, are pregnant or nursing, are taking warfarin or other anticoagulant medicines, or have a history of allergic reactions to aspirin or other NSAIDs.

Interactions

Naproxen can interact with other medications and supplements. Consult with your healthcare provider before taking any over-the-counter or prescription medications or supplements to ensure there will not be an interaction.

Disease Interactions

Naproxen is known to interact with certain medical diseases or conditions. Tell your healthcare provider about any medical diseases or conditions you may have before starting naproxen or any other medications.

Drug Interactions

Naproxen is known to interact with certain medications. Tell your healthcare provider about any medications or supplements you are taking, even if they are over-the-counter, to ensure there will not be an interaction.

Food Interactions

Naproxen should not be taken with alcohol. Additionally, grapefruit and grapefruit juice have the potential to interact with naproxen and should be avoided while taking this medication.

Pregnancy Use

Naproxen should be avoided in pregnant women and women who are planning to become pregnant. It should not be used during the first and third trimesters of pregnancy, when it has been associated with some birth defects.

Lactation Use

Naproxen should not be used by nursing mothers due to the potential for serious adverse effects in the nursing infant.

Acute Overdose

Acute overdose of naproxen can result in serious side effects such as drowsiness, seizures, coma, confusion, rapid heart rate, breathing problems, stomach upset, and vomiting. If you think you or someone else may have taken too much naproxen, seek emergency medical help right away.

Contraindication

Naproxen should not be used in people who have had a serious reaction to other NSAIDs, any allergies, or any active or past bleeding problems.

Use Directions

Naproxen should be taken exactly as directed by your healthcare provider. Do not take more or less than is prescribed and do not take it for a longer time than is recommended.

Storage Condition

Naproxen should be stored at room temperature, away from direct sunlight and heat. Keep out of the reach of children and pets.

Volume of Distribution

The volume of distribution of naproxen is approximately 0.6 liters per kilogram (L/kg).

Half Life

The half-life of naproxen is approximately 13 to 17 hours.

Clearance

The clearance of naproxen is approximately 0.2 liters per hour (L/hr).

Here you find in details version of Naproxen

Some Frequently Asked Questions About Naproxen

What is Naproxen?

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) used to treat a variety of conditions like arthritis, tendinitis, bursitis, ankylosing spondylitis, and menstrual cramps.

How does Naproxen work?

Naproxen works by reducing hormones that cause inflammation and pain in the body. In addition, it may also block certain enzymes that are involved in the formation of pain-causing chemicals.

Who should not take Naproxen?

People who have had a recent heart attack, stroke, or bleeding in the stomach or intestines should not take Naproxen. Additionally, those with kidney or liver disease, bleeding disorders, or who are allergic to aspirin or other NSAIDs should not take this medication.

What are the possible side effects of Naproxen?

The most common side effects of Naproxen are nausea, heartburn, headache, dizziness, drowsiness, rashes, and swelling. It may also increase the risk of bleeding or ulcers in the stomach or intestines. In rare cases, taking Naproxen may lead to kidney or liver problems.

How is Naproxen taken?

Naproxen should be taken as directed by a healthcare provider. It is usually taken with food or milk in order to reduce stomach upset. It is generally taken one to three times daily, depending on the condition being treated.

What is the difference between Naproxen and Ibuprofen?

Naproxen and ibuprofen are similar NSAID pain medications. However, Naproxen is longer-acting and may be more effective in treating certain pain conditions. Talk to your doctor to determine which medication is best for you.

What is the recommended dose of Naproxen?

The recommended dose of Naproxen depends upon the condition being treated. Generally, for adults, the starting dose is 250-500 mg twice daily. It should be taken with food or milk to reduce stomach upset.

Can I take Naproxen with other medications?

Naproxen may interact with other medications, including aspirin and other NSAIDs, anticoagulants, steroids, and certain antibiotics. Talk to your doctor before taking any other medications along with Naproxen.

Is Naproxen safe for pregnant women?

Naproxen is not recommended for pregnant women unless directed by a healthcare professional. It is not known if Naproxen can harm the developing fetus. Naproxen should not be taken by breastfeeding women.

What should I do if I miss a dose of Naproxen?

If you miss a dose of Naproxen, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the next dose as scheduled.

What should I avoid while taking Naproxen?

Alcohol, caffeine, napping, or strenuous activity should be avoided while taking Naproxen. Additionally, do not take aspirin while taking Naproxen as it may increase the risk of bleeding and stomach ulcers.

What are the symptoms of an allergic reaction to Naproxen?

Symptoms of an allergic reaction to Naproxen may include a rash, hives, itching, difficulty breathing, tightness in the chest, or swelling of the mouth, face, lips, or tongue.

Can I take Naproxen if I have high blood pressure?

Naproxen may increase the risk of high blood pressure and should not be taken by people with existing high blood pressure unless directed by a healthcare professional.

Can I take Naproxen with other pain relief medications?

Naproxen may interact with other medications used for pain relief and should not be taken with aspirin, ibuprofen, or other NSAIDs without talking to your doctor first.

What are the long-term side effects of taking Naproxen?

Long-term use or excessive doses of Naproxen may increase the risk of developing kidney or liver problems, as well as heart attack, stroke, or bleeding in the stomach or intestines. Talk to your doctor if you have any concerns.

Is Naproxen addiction a concern?

Naproxen is not known to be habit-forming. However, it should not be taken for longer than recommended by your doctor.

Can I take Naproxen if I am over 65 years old?

Naproxen is generally safe for people over 65, although they may require a lower dose. Talk to your doctor to determine if Naproxen is safe for you.

How long does Naproxen take to work?

Naproxen usually begins to work within 1 to 2 hours of taking it. It may take up to 2 days to reach the maximum effect.

What should I do if I am taking Naproxen and experience stomach upset?

If you are experiencing stomach upset while taking Naproxen, try taking the medicine with food or milk. If the upset persists, talk to your doctor about other options.

Can taking Naproxen cause constipation?

Yes, taking Naproxen may cause constipation or indigestion. To help prevent constipation, increase your dietary fiber and drink plenty of fluids.

Can I take Naproxen if I am diabetic?

Naproxen may affect blood sugar levels, so it is important to monitor your blood sugar levels closely while taking this medication. Talk to your doctor if you have any concerns.

Is there an alternative to Naproxen?

Naproxen may be used as an alternative to other pain medications, such as ibuprofen or aspirin. Talk to your doctor to determine the best treatment for your condition.

Can children take Naproxen?

Naproxen is not recommended for children under 12 years old. Children 12 years and older may take Naproxen when directed by a healthcare professional.

Can I take Naproxen if I am on blood thinners?

Naproxen may increase the risk of bleeding and should not be taken by people taking blood thinners or other medications that may increase the risk of bleeding. Talk to your doctor about any medications you are taking.

Can taking Naproxen cause dizziness?

Yes, taking Naproxen may cause dizziness or drowsiness, which may affect your ability to drive or operate machinery. Talk to your doctor if you experience dizziness while taking Naproxen.

Can I take Naproxen if I am taking medication for high blood pressure?

Naproxen may increase the risk of high blood pressure and should not be taken by people with existing high blood pressure unless directed by a healthcare professional. Talk to your doctor about the risks and benefits of taking both medications.

Can I take Naproxen with antihistamines?

Yes, it is generally safe to take Naproxen with antihistamines, however it is important to note that they may interact with other medications. Always talk to your doctor before taking any medications together.

Can I take Naproxen with steroids?

Naproxen can interact with certain steroids and should not be taken with them unless directed by a healthcare professional. Talk to your doctor about any medications you are taking.

Can taking Naproxen cause elevated liver enzymes?

Yes, taking Naproxen for an extended period of time or in high doses may increase the risk of elevated liver enzymes. Talk to your doctor if you experience any signs or symptoms of liver problems.

Can I take an antacid while taking Naproxen?

Yes, it is generally safe to take antacids while taking Naproxen. However, it is important to note that antacids may interact with other medications. Always talk to your doctor before taking any medications together.

Can I take Naproxen if I have a history of GI problems?

Naproxen may increase the risk of developing stomach or intestinal irritation or bleeding and should not be taken by people with a history of GI problems unless directed by a healthcare professional.

Can taking Naproxen cause headaches?

Yes, headaches are a common side effect of taking Naproxen. If you are experiencing headaches while taking Naproxen, talk to your doctor about other options.

Can taking high doses of Naproxen cause kidney damage?

Taking high doses of Naproxen may increase the risk of developing kidney damage. Talk to your doctor about the risks and benefits of taking this medication.

Can I take Naproxen if I have asthma?

Naproxen may increase the risk of asthma attacks in some people and should not be taken by people with asthma unless directed by a healthcare professional.

What can I do if I experience nausea while taking Naproxen?

Taking Naproxen with food or milk may help reduce nausea. If the nausea persists, talk to your doctor about other options.

Is there a generic version of Naproxen?

Yes, there is a generic version of Naproxen available. Talk to your doctor or pharmacist about cost options for the generic version of this medication.

Can taking Naproxen cause elevated cholesterol levels?

Yes, taking Naproxen may increase the risk of elevated cholesterol levels. Talk to your doctor if you have any concerns.

Can I take Naproxen if I am taking a blood pressure medication?

Yes, it is generally safe to take Naproxen with blood pressure medications, however it is important to note that they may interact with other medications. Always talk to your doctor before taking any medications together.

Is Naproxen available over-the-counter?

Yes, Naproxen is available in some states over-the-counter. Always read the label and talk to your doctor or pharmacist before taking any medication.

Is there a natural alternative to Naproxen?

Yes, some people find relief with natural alternatives such as acupuncture, yoga, massage, and heat or cold therapy. Talk to your doctor to determine the best treatment for your condition.