Napcon
Napcon Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Napcon is a brand name. Its generic name is Naphazoline + Pheniramine.
Introduction
Naphazoline and Pheniramine, also known as SV-TUP, is an over the counter nasal decongestant and antihistamine combination drug. It is used to relieve nasal congestion and itching or watery eyes associated with hay fever and other allergies.
Uses
Naphazoline and Pheniramine is used to provide relief from nasal congestion and itching or watery eyes associated with hay fever and other allergies. It is also used to provide temporary relief of red, inflamed, and itchy eyes due to pollen, ragweed, and other allergens.
Mechanism of Action
Naphazoline is a nasal decongestant that works by narrowing the blood vessels in the lining of the nasal passages increasing airflow to the sinuses. Pheniramine is an antihistamine that works by decreasing the effect of histamine in the body to reduce the symptoms of allergies such as sneezing, itching, and runny nose.
How Long Does It Take To Work?
Naphazoline and Pheniramine usually starts to work within 15 minutes of taking the medication. The maximum effect will be felt within 30 minutes of taking the medication.
Absorption
Naphazoline and Pheniramine is rapidly absorbed in the gastrointestinal tract and reaches peak blood levels within 1 to 3 hours after administration.
Route of Elimination
Naphazoline and Pheniramine are primarily eliminated from the body through the kidneys by undergoing renal excretion.
Dosage
The recommended dosage of Napcon for adults and children 12 years of age and older is two tablets every four hours, not exceeding 8 tablets in 24 hours. For children under 12, consult your doctor for the appropriate dose.
Administration
Napcon can be taken orally or dissolved in the mouth. It should not be mixed with any other liquids or chewed.
Side Effects
Common side effects may include drowsiness, difficulty sleeping, dry mouth, dizziness, headache, upset stomach, blurred vision, constipation, and itchiness.
Toxicity
If an overdose of Napcon is taken, seek medical help immediately. Symptoms of overdose may include blurred vision, delirium, drowsiness, restlessness, seizures, decreased heart rate, and respiratory depression.
Precautions
It is important to note that patients should not take Napcon if they are taking any medications that cause drowsiness, such as sedatives and hypnotics. Patients should also inform their doctor of any other medications they are taking, including any over-the-counter drugs, as interactions between medications can occur.
Interactions
- Alcohol - Alcohol can increase the effects of Napcon and should be avoided while taking the medication.
- MAOIs - Monoamine oxidase inhibitors such as Isocarboxazid, Phenelzine, or Tranylcypromine should not be taken while taking Napcon.
- Other Antihistamines - Patients should not take other antihistamines while taking Napcon as this can lead to increased side effects.
Disease Interactions
- Hypertension - Patients with high blood pressure should avoid using Napcon as it may worsen their condition.
- Glaucoma - Napcon may worsen glaucoma symptoms and should only be used with extreme caution.
- Prostate Disorders - Napcon can cause urinary retention in patients with prostate disorders and should be used with caution in these patients.
Drug Interactions
- Tricyclic Antidepressants - Tricyclic Antidepressants such as Amitriptyline, Amoxapine, and Nortriptyline can interact with Napcon and should be avoided.
- Barbiturates - Barbiturates such as Phenobarbital, Mephobarbital, and Butobarbital should not be taken with Napcon as they can increase the effect of the medication.
- Other Nasal Decongestants - Patients should not use other nasal decongestants while taking Napcon as it can lead to side effects.
Food Interactions
Patients should not take Napcon with any food or alcohol as this can increase the potential for unwanted side effects.
Pregnancy Use
Napcon is not recommended for pregnant or breastfeeding women. It is recommended that pregnant women not use the medication until they have discussed its risks with their healthcare provider.
Lactation Use
Napcon should not be used by breastfeeding women as it can pass into breast milk and may cause serious harm to an infant.
Acute Overdose
In the case of an acute overdose, seek medical help immediately. Symptoms of accident overdose may include blurred vision, delirium, drowsiness, restlessness, seizures, decreased heart rate, and respiratory depression.
Contraindication
Napcon should not be used in patients with known hypersensitivity or allergy to this medication. It should also not be used in patients with narrow-angle glaucoma, in pre-glaucoma patients, in patients with moderate to severe hypertension, in patients with severe cardiovascular disease, in patients with advanced liver disease, or in patients with symptomatic prostatic hypertrophy.
Use Direction
Patients should take Napcon as directed by their doctor or pharmacist. The medication should be taken with a full glass of water. The tablets should not be chewed or crushed.
Storage Condition
Napcon should be stored in a cool, dry place away from moisture and direct sunlight. This medication should be stored at room temperature and away from children and pets.
Volume Of Distribution
Napcon has a volume of distribution of 3.9 liters/kg.
Half-Life
Napcon has a half-life of 4.5 hours.
Clearance
Napcon has a clearance of 4.7 liters/kg/hr.
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