MTP

MTP Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? MTP is a brand name. Its generic name is Mifepristone + Misoprostol.

Introduction

Mifepristone and Misoprostol are two medicines commonly used in combination to terminate a pregnancy. Mifepristone is an anti-progestin, which blocks the action of progesterone and prevents the pregnancy from progressing. Misoprostol is a prostaglandin, which causes uterine contractions to expel the contents of the uterus.

Uses for

Mifepristone and Misoprostol can be used to terminate a pregnancy up to 10 weeks of gestational age. It is a safe and effective way for a woman to end a pregnancy in the privacy of her own home.

Mechanism of Action

Mifepristone is an anti-progesterone, which blocks the action of progesterone. Progesterone helps maintain the lining of the uterus, but when it is blocked, it can cause the uterus to shed its lining, which leads to the expulsion of the pregnancy. Misoprostol is a prostaglandin, which causes the uterus to contract and helps expel the pregnancy.

How Long Does It Take to Work?

Mifepristone and Misoprostol usually take about two to four hours to work. Most women will experience bleeding and cramping, which may last a few hours or up to a few days. In some cases, a second dose of Misoprostol may be necessary.

Absorption

Mifepristone and Misoprostol are both rapidly absorbed after oral administration. Mifepristone is rapidly metabolized to its active metabolites, which can be detected in the blood within 2-3 hours.

Route of Elimination

Mifepristone and Misoprostol are both primarily eliminated in the feces. The metabolites of mifepristone can also be found in the urine.

Dosage

The recommended dose of mifepristone and misoprostol to terminate a pregnancy up to 10 weeks of gestation is as follows:

• Mifepristone: 600 mg orally
• Misoprostol: 800 mcg orally

Administration

Mifepristone and Misoprostol should be taken orally with water or juice. The medicines can be taken together or separately, but it is preferred to take them together for the most effective results.

Side Effects

The most common side effects associated with mifepristone and misoprostol include nausea, vomiting, diarrhea, cramping, and vaginal bleeding. Other side effects may include headache, dizziness, and fatigue.

Toxicity

Mifepristone and misoprostol are generally well-tolerated, but an overdose can cause serious complications, including seizures, coma, and death. If an overdose is suspected, it is important to seek medical attention immediately.

Precaution

Mifepristone and misoprostol should not be used in women with an ectopic pregnancy or who have an allergy to mifepristone or misoprostol. It should also not be used in women who are taking other medications, including anticoagulants, corticosteroids, or nonsteroidal anti-inflammatory drugs.

Interaction

Mifepristone and misoprostol can interact with other medications. Before beginning any new medications, women should tell their healthcare provider if they are taking mifepristone or misoprostol.

Disease Interaction

Mifepristone and misoprostol should not be used in women with certain conditions, including heart disease, uncontrolled high blood pressure, anemia, or history of blood clots.

Drug Interaction

Mifepristone and misoprostol can interact with other medications, including anticoagulants, corticosteroids, and other nonsteroidal anti-inflammatories, and can cause serious side effects. Women should inform their healthcare provider if they are currently taking any medications before taking mifepristone or misoprostol.

Food Interactions

Mifepristone and misoprostol should be taken with food to reduce the risk of side effects. Women should not take mifepristone and misoprostol with grapefruit juice or other grapefruit containing products.

Pregnancy Use

Mifepristone and misoprostol should not be used in women who are pregnant. Women should not take this medication if they think they may be pregnant.

Lactation Use

Mifepristone and misoprostol should not be used in women who are breastfeeding. Women should not take this medication if they think they may be breastfeeding.

Acute Overdose

Overdose of mifepristone and misoprostol can be life-threatening and should be immediately treated by a medical professional. Symptoms of an overdose include seizures, pulmonary edema, coma, and death.

Contraindication

Mifepristone and misoprostol should not be used in women with certain medical conditions, including an ectopic pregnancy, allergy to mifepristone or misoprostol, history of blood clots, heart disease, uncontrolled high blood pressure, or anemia.

Use Direction

Mifepristone and misoprostol should be taken orally with food and water. The tablets should not be chewed or crushed before taking them. Women should take the medicines as soon as possible, following the instructions provided by their healthcare provider.

Storage Condition

Mifepristone and misoprostol should be stored in a cool, dry place away from light and moisture. The tablets should not be frozen, and should be kept out of the reach of children.

Volume of Distribution

Mifepristone and misoprostol are rapidly distributed throughout the body. Mifepristone is metabolized in the liver and its active metabolites are distributed to target tissues.

Half Life

The half-life of mifepristone is approximately two hours, and the half-life of misoprostol is approximately three hours.

Clearance

Mifepristone is metabolized in the liver and its active metabolites are rapidly cleared from the body. Misoprostol is rapidly eliminated in the feces.

Here you find in details version of MTP

Some Frequently Asked Questions About MTP

What is MTP?

MTP is a combination of two drugs which are used for the termination of an early pregnancy, typically less than nine weeks from the last menstrual period.

What is the difference between Mifepristone and Misoprostol?

Mifepristone is an antiprogestogen, which interferes with the action of progesterone, a hormone essential for pregnancy maintenance. Misoprostol is an prostaglandin analog which stimulates uterine contractions and leads to the expulsion of the fetal tissue.

What are the side effects of using Mifepristone and Misoprostol?

The most common side effects of using Mifepristone and Misoprostol are nausea, vomiting, diarrhea, abdominal pain, headache, dizziness and fatigue. Further side effects include chills, fever, abnormal uterine bleeding, backache or cramps similar to that experienced during menstruation.

How effective is MTP in terminating early pregnancy?

MTP is effective in terminating an early pregnancy. According to research, the combination of drugs is 95% effective in terminating successfully an early pregnancy.

What happens after taking MTP?

After taking MTP, you may experience cramping and bleeding, which typically begins two to four hours after taking the second medication, Misoprostol. The cramping and bleeding may continue for several days.

What should I do if I miss a dose of MTP?

Missing a dose is best to be avoided. If you miss a dose, please contact your healthcare provider as soon as possible.

How soon will I see results after taking MTP?

Results of termination can be seen within 4-6 hours after taking MTP. However, it may take up to 2 weeks for the process to be completed.

Is it safe to take MTP if I have an allergy to certain medications?

Before using MTP, it is best to consult with a healthcare professional to determine if an allergy to certain medications may have a negative reaction when taking this combination.

Can MTP be used to terminate a pregnancy beyond nine weeks?

MTP is typically used to terminate a pregnancy within nine weeks from the last menstrual period. If the pregnancy is over nine weeks, it is best to consult a healthcare professional to find the safest and most effective method for the termination of the pregnancy.

Do I need to have a physical exam before taking MTP?

It is recommended to have a physical exam before taking MTP. A physical exam can determine the accurate age and location of the pregnancy, as well as rule out any underlying conditions which may affect the outcome of the procedure.

If I take MTP, will I be able to get pregnant in the future?

Yes. Termination of a pregnancy using MTP does not affect your ability to become pregnant in the future.

Are there any long-term side effects of taking MTP?

Most side effects associated with MTP are short term and dissipate within weeks of usage. There are no known long-term side effects associated with this combination.

Can I use MTP if I have an underlying condition such as diabetes or high blood pressure?

It is best to consult with a healthcare professional prior to taking MTP if you have an underlying condition such as diabetes or high blood pressure. The doctor taking care of you will be able to provide an accurate assessment of the best course of action.

Is there any risk of infection after taking MTP?

There is a low risk of infection associated with taking MTP. It is recommended to consult a healthcare professional if any signs of infection are noticed, such as fever or an increase in vaginal discharge.

Are there any medications that should not be taken while using MTP?

MTP should not be taken with any medications that contain estrogen such as birth control pills. As well, any medication that affects the clotting of blood such as warfarin should not be taken while using MTP.

Should I take MTP in the morning or evening?

It is recommended to take MTP in the morning in order to facilitate the passing of the fetal tissue more easily.

Do I need to have a follow-up visit after taking MTP?

It is recommended to have a follow-up appointment after taking MTP. Your healthcare provider will be able to verify that the abortion is complete and rule out any side effects or complications.

Can I take pain medications while taking MTP?

Yes. It is recommended to take over-the-counter pain medications such as ibuprofen to manage any discomfort associated with the abortion.

Can I take MTP if I am breastfeeding?

It is not recommended to take MTP if you are breastfeeding. Please consult a healthcare professional for further information and recommendations.

Can I exercise or have sexual intercourse while taking MTP?

It is not recommended to exercise or engage in sexual intercourse while taking MTP. As well, it is best to avoid hot tubs or saunas in order to prevent an infection.

Can I take MTP if I am pregnant with twins or triplets?

MTP is only recommended for an early pregnancy with a single fetus. If you are pregnant with twins or triplets, it is best to consult with a healthcare professional for further evaluation and recommendations.

How much blood loss should I expect after taking MTP?

It is normal to experience some bleeding after taking MTP. The amount varies and typically lasts for several days, similar to a heavy menstrual cycle.

Can I take MTP if I am allergic to any medications?

Before taking MTP, it is best to consult with a healthcare professional to determine if an allergy to any medications may have a negative reaction when taking this combination.

What is the age limit for taking MTP?

It is best to consult with a healthcare professional regarding the appropriate age for taking MTP.

Can I take MTP if I'm using an IUD (intrauterine device)?

It is recommended that the IUD be removed prior to taking MTP. Please contact your doctor to discuss the best course of action.

Can MTP be used as a form of birth control?

No. MTP is not recommended to be used as a form of birth control.

Is MTP available in all countries?

No. MTP may not be available in all countries. It is best to consult with a healthcare professional in your country for availability.

What is the cost of MTP?

The cost of MTP may vary from country to country and with your health insurance coverage. It is best to consult with a healthcare professional regarding the cost of this medication.

Can I take MTP if I have a history of cancer?

It is recommended to consult with a healthcare professional prior to taking MTP if you have a history of cancer.

Can I take MTP if I have had an ectopic pregnancy?

No, MTP should not be taken if you have had an ectopic pregnancy. Please consult with a healthcare professional for further evaluation and advice.

Can I take MTP if I have had a cesarean section?

It is best to consult with a healthcare professional prior to taking MTP if you have had a cesarean section.

Can I take MTP if I have kidney or liver issues?

It is best to consult with a healthcare professional prior to taking MTP if you have kidney or liver issues.

How can I be sure that MTP has been successful in terminating my pregnancy?

It is best to have a follow-up visit with a healthcare professional to ensure that the abortion has been successful. Ultrasound or blood tests may be requested in order to confirm the termination.

Do I need to be monitored while taking MTP?

It is not necessary to be monitored while taking MTP. However, it is best to consult with a healthcare professional prior to taking the medication.

Should I take MTP if I have a miscarriage?

MTP is used to terminate a pregnancy. If you are having a miscarriage, it is best to consult with a healthcare professional to receive a complete and accurate diagnosis.

Do I need to abstain from any activity while taking MTP?

It is best to avoid any strenuous activity, such as exercise, while taking MTP.

When should I follow up with my healthcare provider after taking MTP?

It is recommended to set up a follow-up appointment with your healthcare provider at least one week after taking MTP.

Can I take MTP with other medications?

It is not recommended to take any other medications while taking MTP. Please consult a healthcare professional prior to taking any other medications.

Do I need to take additional medication after taking MTP?

You may be prescribed additional medication after taking MTP such as antibiotics or anti-inflammatory drugs. It is best to follow the recommendations of your healthcare provider.

Can I travel while taking MTP?

It is best to avoid travelling while taking Mifepristone + Mis