Manoriz

Manoriz Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Manoriz is a brand name. Its generic name is Rizatriptan.

Manoriz: Introduction

Manoriz (Maxalt, Maxalt-MLT) is a serotonin 5-HT1B/1D receptor agonist and antimigraine drug. It is used to treat acute migraine attacks, with or without aura (temporary visual disturbances or other symptoms), in adults. Manoriz relieves migraine pain and associated symptoms such as nausea and sensitivity to sound and light.

Uses For

Manoriz is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Manoriz will not prevent the occurrence of migraine headaches.

Mechanism of Action

Manoriz is a serotonin 5-HT1B/1D receptor agonist with antimigraine activity. It binds selectively and with high affinity to 5-HT1B and 5-HT1D receptors, resulting in serotonin-mediated constriction of arteriolar blood vessels in the brain, relief from pain, and a decrease in inflammation. It is also thought to inhibit release of neuropeptides such as CGRP (calcitonin gene-related peptide), which is associated with migraine.

How Long Does it Take to Work?

Manoriz usually begins to work within 30 minutes of taking the tablet, and reaches its peak effect within two hours.

Absorption

Manoriz is rapidly and well-absorbed from the gastrointestinal tract. The absolute bioavailability is 25%, because of presystemic metabolism. Peak plasma concentrations occur 1-2 hours after oral administration. The bioavailability of Maxalt-MLT (a lyophilized orally disintegrating tablet) is comparable to that of Maxalt.

Route of Elimination

Manoriz is eliminted primarily by hepatic metabolism and biliary excretion of metabolites. The drug has a plasma terminal elimination half-life of about 2 to 3 hours.

Dosage

The usual recommended adult dose of rizatriptan is 5 to 10 mg. Dose can be increased to a maximum of 30 mg in a 24-hour period.

Administration

Manoriz tablets should be taken whole. They should not be chewed, split, or dissolved. Maxalt-MLT orally disintegrating tablets should be placed on the tongue and allowed to dissolve without being chewed or swallowed.

Side Effects

The most common side effects of rizatriptan include dizziness, headache, fatigue, dry mouth, and nausea. Less common side effects include chest pain, flushing or warmth, hot flashes, muscle tightness or pain, sleepiness, tingling sensations, throat irritation, tightness or heaviness.

Toxicity

Overdoses of rizatriptan can produce symptoms of serotonin syndrome, including agitation, confusion, fast heartbeat, sweating, tremor, diarrhea, or vomiting.

Precautions

Before using rizatriptan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Manoriz should not be used if you have certain medical conditions, such as ischemic heart disease, coronary artery vasospasm, history of stroke or TIA, or hemiplegic or basilar migraine.

Interactions

Manoriz may interact with other medications such as MAO inhibitors, propranolol, dihydroergotamine, or St. John's wort. Tell your doctor all medications you are currently taking, including those over-the-counter.

Disease Interactions

Manoriz is not recommended in patients with ischemic heart disease, coronary artery vasospasm, history of stroke or TIA, or hemiplegic or basilar migraine.

Drug Interactions

Manoriz may interact with MAO inhibitors, propranolol, dihydroergotamine, or St. John's wort. Tell your doctor all medications you are currently taking, including those over-the-counter.

Food Interactions

Manoriz should be taken at least two hours after or one hour before a meal. Taking Manoriz with food may increase the rate of absorption, resulting in increased systemic exposure and increased the risk of side effects.

Pregnancy Use

Manoriz should not be used in pregnant women unless the potential benefit outweighs the potential risk to the fetus.

Lactation Use

It is not recommended to use rizatriptan during breastfeeding. Consult your doctor before taking this medication during lactation.

Acute Overdose

Symptoms of an acute overdose of rizatriptan may include nausea, vomiting, confusion, dizziness, double vision, dizziness, sweating, tremor, diarrhea, or vomiting.

Contraindication

Manoriz is contraindicated in patients with ischemic heart disease, coronary artery vasospasm, history of stroke or TIA, or hemiplegic or basilar migraine.

Use Directions

To take rizatriptan, you should take one 5 to 10 mg tablet with water as soon as you experience migraine symptoms. Do not take more than 30 mg in 24 hours. If the headache returns after a period of relief, you can take second dose 2 hours later (maximum 30 mg per day). Do not take rizatriptan more than twice every 24 hours. If the symptoms do not improve, contact your doctor.

Storage Conditions

Manoriz should be stored at room temperature, away from heat, moisture, and light. Keep out of reach of children.

Volume of Distribution

The average apparent volume of distribution of rizatriptan is about 165 liters.

Half Life

The elimination half-life of rizatriptan is approximately 2-3 hours.

Clearance

The apparent clearance of rizatriptan after intravenous administration is approximately 10 liters/hour.

Here you find in details version of Manoriz

Some Frequently Asked Questions About Manoriz

What is Manoriz?

Manoriz is a medication used to treat migraine headaches. It is a prescription medication available in tablet and orally disintegrating tablet form.

What is the generic name for Manoriz?

The generic name for Manoriz is rizatriptan benzoate.

How does Manoriz work?

Manoriz works by narrowing the blood vessels around the brain and relieving the symptoms of a migraine headache. It also helps to reduce substances in the body that can cause headache, nausea, sensitivity to light and sound, and other migraine symptoms.

How long does it take for Manoriz to work?

Manoriz usually begins to work within 30 minutes after taking the tablet. However, it can take up to two hours for the full effects of the medication to be felt.

How much does Manoriz cost?

The cost of Manoriz will depend on the dosage and quantity prescribed. It is recommended that you speak with your healthcare provider to determine the cost of your prescription.

What are the potential side effects of Manoriz?

The most common side effects of Manoriz include drowsiness, dizziness, tingling or numbness in extremities, fatigue, muscle or body aches, and nausea. Other more serious side effects include an irregular heartbeat, chest pain, and difficulty breathing. If you experience any of these side effects, contact your healthcare provider immediately.

Can I take Manoriz while pregnant?

It is not recommended that Manoriz be taken while pregnant as its safety has not been established in pregnant women. Speak with your healthcare provider about the best treatment for your migraines while pregnant.

Can I take Manoriz while breastfeeding?

It is not recommended that Manoriz be taken while breastfeeding as its safety has not been established in breastfeeding women. Speak with your healthcare provider about the best treatment for your migraines while breastfeeding.

Is Manoriz covered by my insurance?

The coverage of Manoriz by your insurance policy will depend on your individual coverage. It is recommended that you contact your insurance provider to determine if your prescription will be covered.

Can I take Manoriz with other medications?

It is generally recommended that you do not take Manoriz with other medications without speaking to your healthcare provider first. This is especially true if you are taking medications that affect serotonin levels in the body, such as antidepressants.

Does Manoriz interact with any foods or alcohol?

Manoriz may interact with certain foods or beverages, such as alcohol, caffeinated drinks, and certain types of cheese. It is generally recommended that you avoid consuming these foods or drinks while taking Manoriz.

What should I do if I miss a dose of Manoriz?

If you miss a dose of Manoriz, take it as soon as you remember. Do not take a double dose to make up for the missed dose. Contact your healthcare provider if you think you need a different dosing schedule.

Can I take Manoriz daily?

Manoriz is not intended to be taken on a daily basis. If you are having daily migraine headaches, contact your healthcare provider to discuss other treatment options.

Does Manoriz expire?

Yes, Manoriz tablets and orally disintegrating tablets do have an expiration date. Always check the expiration date on the package and do not use the medication if it is expired.

Can I take Manoriz with acetaminophen?

It is generally not recommended that you take Manoriz with acetaminophen. Speak with your healthcare provider to determine if it is safe for you to take both medications together.

Can I take Manoriz if I have kidney disease?

If you have kidney disease, it is recommended that you speak with your healthcare provider before taking Manoriz. Your healthcare provider may adjust the dosage or frequency of the medication depending on the severity of your kidney disease.

What should I do if I overdose on Manoriz?

If you think you may have overdosed on Manoriz, it is important to seek medical attention immediately. Signs of an overdose may include seizures, loss of consciousness, difficulty breathing, chest pain, irregular heartbeat, or confusion.

Can I take Manoriz while taking other migraine treatments?

It is generally recommended that Manoriz should not be taken with other migraine treatments such as triptans, opioids, or other ergots. If you need to take other medications for your migraines, speak to your healthcare provider to ensure it is safe to do so.

Is Manoriz habit forming?

No, Manoriz is not habit forming. However, if you do need to take the medication often, speak with your healthcare provider to ensure it is appropriate for your condition.

Can Manoriz be cut or split?

Manoriz tablets should not be split, chewed, or crushed. If you have difficulty swallowing the tablets, you may take the orally disintegrating tablets, which dissolve on the tongue.

Who should not take Manoriz?

Manoriz should not be taken if you are allergic to it or have experienced a reaction to taking triptans. It should also not be taken if you are currently taking monoamine oxidase inhibitors or if you have heart disease, stroke, or circulation problems.

Can Manoriz be used to treat cluster headaches?

No, Manoriz is not proven to be effective in treating cluster headaches. Speak to your healthcare provider about other treatment options for cluster headaches.

How should Manoriz be stored?

Manoriz should be stored at room temperature, away from direct light and moisture. Do not store it in the bathroom or near any heat sources. Make sure to keep it out of the reach of children and pets.

Can I take Manoriz if I have high blood pressure?

If you have high blood pressure, it is recommended that you speak to your healthcare provider before taking Manoriz. Your healthcare provider may determine that taking Manoriz is appropriate for you.

Can I take Manoriz if I am taking birth control?

Yes, it is generally safe to take Manoriz if you are taking birth control medication. However, it is recommended that you speak to your healthcare provider just to make sure.

Can I take Manoriz if I have a history of stroke?

No, you should not take Manoriz if you have had a stroke or if you have circulation problems. Speak with your healthcare provider about other treatment options.

Can Manoriz be used to prevent migraines?

No, Manoriz is not indicated for the prevention of migraines. Speak with your healthcare provider to discuss other preventive treatment options.

Can I take Manoriz if I am over 65?

Yes, it is generally safe for those over 65 to take Manoriz. However, it is always recommended that you speak to your healthcare provider before taking any medication.

Does Manoriz have any drug interactions?

Yes, there are several medications that can interact with Manoriz. These include serotonin antagonists, monoamine oxidase inhibitors, medications that affect serotonin levels in the body, and isocarboxazid. It is important to speak with your healthcare provider or pharmacist to make sure it is safe to take Manoriz while taking other medications.

What should I know before taking Manoriz?

Before taking Manoriz, it is important to discuss your medical history with your healthcare provider. Make sure to let them know about any other medications you are taking, any allergies you have, and any other medical or mental health conditions you have.

Is Manoriz available in generic form?

Yes, Manoriz is available in generic form. It is important to let your healthcare provider know that you would prefer the generic version of the medication and make sure to confirm the dosage and quantity before leaving the pharmacy.

What should I do if I experience side effects from Manoriz?

If you experience side effects from Manoriz, speak to your healthcare provider immediately. They may be able to adjust the dosage or frequency of the medication, or offer alternative treatment options.

Can I take Manoriz while taking warfarin?

Yes, it is generally safe to take Manoriz while taking warfarin. However, it is important to speak to your healthcare provider or pharmacist to make sure that it is safe to do so.

Does Manoriz cause weight gain?

Weight gain is not a known side effect of Manoriz. However, if you do experience sudden and unexplained weight gain while taking Manoriz, contact your healthcare provider.

What is the recommended dosage of Manoriz?

The recommended dosage of Manoriz for adults is 5 or 10 mg, taken as soon as the headache symptoms begin. Do not exceed the recommended dosage and do not take more than 30 mg in a 24 hour period.

Does Manoriz have any effect on fertility?

There is currently no evidence that Manoriz affects fertility in either men or women. However, if you are nursing, pregnant, or planning to become pregnant, speak to your healthcare provider about the potential risks of taking Manoriz.

Is Manoriz approved by the FDA?

Yes, Manoriz is approved for use by the US Food and Drug Administration (FDA).

Does Manoriz cause constipation?

Constipation is not a common side effect of Manoriz. However, if you experience constipation while taking Manoriz, contact your healthcare provider.

Can I take Manoriz if I have liver disease?

If you have liver disease, it is recommended that you speak to your healthcare provider before taking Manoriz. Your healthcare provider may adjust the dosage or frequency of the medication depending on the severity of your liver disease.

Does Manoriz cause drowsiness?

Yes, drowsiness is a common side effect of Manoriz. It is important to be aware of this side effect before taking the medication and before performing any tasks that might require alertness, such as driving or operating heavy machinery.