Lomotil
Lomotil Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Lomotil is a brand name. Its generic name is Atropine + Diphenoxylate.
Lomotil
Atropine and diphenoxylate is a combination medicine used to treat diarrhea in adults and children ages 2 years and older. It is used to treat acute nonspecific diarrhea in adults and children caused by bacterial or viral infection. This medicine also helps to reduce pain and cramping associated with diarrhea.
Introduction
Atropine and diphenoxylate is a combination medication used for the treatment of acute nonspecific diarrhea in adults and children. This medication works by reducing secretions in the gastrointestinal tract and by suppressing the intestinal muscle contractions, helping to slow down the progression of the diarrhea. It can also help to reduce the pain and cramping associated with abnormal contractions.
Uses for
Atropine and diphenoxylate is used to reduce diarrhea symptoms in adults and children. It is commonly used to treat acute nonspecific diarrhea caused by bacterial or viral infection. It works by reducing secretions in the gastrointestinal tract and suppressing the intestinal muscle contractions, thereby slowing down the progression of the diarrhea.
Mechanism of Action
Atropine and diphenoxylate works by reducing the excessive secretion of fluids in the gastrointestinal tract and by suppressing abnormal contractions of the intestines. It works by blocking the action of acetylcholine, a chemical released by the parasympathetic nervous system, which is responsible for inducing secretions in the intestine. Diphenoxylate also helps to reduce the intestinal muscle contractions, and as a result slows down the progression of diarrhea.
How Long Does It Take To Work?
Atropine and diphenoxylate typically starts to work within 30 minutes to one hour after ingestion, although the exact time frame may vary depending on the individual. It is important to take the medication as directed to get the best results.
Absorption
Atropine and diphenoxylate is generally well absorbed in the gastrointestinal tract. It is primarily metabolized in the liver and is eliminated in the urine and feces within 24 hours of ingestion.
Route of Elimination
Atropine and diphenoxylate is mainly eliminated in the urine and feces. It is metabolized in the liver and mainly excreted as its metabolites, as well as unchanged drug.
Dosage
Atropine and diphenoxylate is available in tablet and oral suspension form. The recommended dose for adults and children over 2 years old is 2 tablets (each containing 0.5 mg atropine and 2.5 mg diphenoxylate) three times a day. For children under 2 years old, the recommended dose is 1 tablet three times a day. The dosage should be adjusted based on the age, severity of the diarrhea, and response to therapy.
Administration
Atropine and diphenoxylate should be taken with a full glass of water. The tablets should be swallowed whole with or without food. Do not chew, crush, or break the tablets. The oral suspension should be shaken well before use and measured using the provided dosing syringe.
Side Effect
Atropine and diphenoxylate may cause some side effects, including dry mouth, blurred vision, increased heart rate, and constipation. It may also cause dizziness, drowsiness, confusion, and restlessness. If these side effects are severe, contact your doctor immediately.
Toxicity
Atropine and diphenoxylate may cause toxicity when taken in high doses. Signs of toxicity include severe nausea, vomiting, increased heart rate, hallucinations, muscle twitching, and seizures. If these signs and symptoms occur, stop taking the medication immediately and seek medical help.
Precautions
Patients taking atropine and diphenoxylate should be monitored closely for signs of toxicity or side effects. The medication should not be taken by patients who are allergic to either of the components of the medication or to similar medications. The risk for toxicity is also increased in patients with liver or kidney disease. Patients should tell their doctor about any allergies, medical history, and other medications they are taking.
Interaction
Atropine and diphenoxylate may interact with certain drugs or medications such as anticonvulsants, antifungals, barbiturates, antihistamines, depressants, diuretics, or other medications used to treat diarrhea. If certain medications are prescribed together, the dose of atropine and diphenoxylate may need to be adjusted. It is important to tell your doctor about all other medicines you are taking, including vitamins and herbs.
Disease Interaction
Atropine and diphenoxylate may not be suitable for patients with certain medical conditions, such as kidney or liver disease, glaucoma, enlarged prostate or bladder obstruction, or asthma. It is important to tell your doctor about all your medical conditions before taking this medication.
Drug Interaction
Atropine and diphenoxylate may interact with other drugs, such as sedatives, anticonvulsants, antifungals, barbiturates, antihistamines, depressants, diuretics, or other medications used to treat diarrhea. If certain medications are prescribed together, the dose of atropine and diphenoxylate may need to be adjusted. It is important to tell your doctor about all other medicines you are taking, including vitamins and herbs.
Food Interactions
Atropine and diphenoxylate may interact with certain foods and drinks, such as alcohol, caffeine, and dairy products. It is recommended to avoid drinking alcohol while taking this medication, as it may increase the risk of side effects. It is also important to avoid drinking large amounts of caffeinated beverages, as it may decrease the effectiveness of the medication.
Pregnancy Use
Atropine and diphenoxylate should not be used during pregnancy unless clearly necessary. If you are pregnant or planning to become pregnant, talk to your doctor before taking this medication.
Lactation Use
Atropine and diphenoxylate is not known to be safe for use during lactation. If you are breast-feeding, talk to your doctor before taking this medication.
Acute Overdose
An acute overdose of atropine and diphenoxylate may cause serious side effects, including nausea, vomiting, confusion, tachycardia, seizures, and coma. If an overdose is suspected, contact your doctor or local poison control center immediately.
Contraindication
Atropine and diphenoxylate should not be used in patients who are allergic to either of the components of the medication or to similar medications. It should also not be used in patients with glaucoma, an enlarged prostate, or bladder obstruction. If you have any of these conditions, talk to your doctor before taking this medication.
Use Direction
Atropine and diphenoxylate should be taken as directed by your doctor. For adults and children over 2 years old, the recommended dose is 2 tablets three times a day. For children under 2 years old, the recommended dose is 1 tablet three times a day. The tablets should be swallowed whole with or without food. Do not chew, crush, or break the tablets.
Storage Condition
Atropine and diphenoxylate should be stored at room temperature. It should be stored in a cool, dry place and away from direct sunlight. If the medication is stored for a long period of time, the expiration date should be checked before use.
Volume of Distribution
The volume of distribution of atropine and diphenoxylate is 4.3 L/kg. This means that the medication is distributed throughout the body with a volume of 4.3 L/kg.
Half Life
The half-life of atropine and diphenoxylate is approximately 2.5 hours. This means that it will take about 2.5 hours for the body
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