Lisdexamfetamine
Lisdexamfetamine Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Lisdexamfetamine is a brand name. Its generic name is Lisdexamfetamine.
Lisdexamfetamine
Lisdexamfetamine, also known as Vyvanse, is a medication used to treat attention-deficit hyperactivity disorder (ADHD). It is a stimulant medication from the amphetamine family. Lisdexamfetamine is thought to work by increasing levels of dopamine and norepinephrine in the brain, which are hormones that affect mood and behavior.
Uses for
Lisdexamfetamine is used to treat Attention Deficit Hyperactivity Disorder (ADHD). It can also be used to treat binge eating disorder.
Mechanism of Action
Lisdexamfetamine works by increasing levels of dopamine and norepinephrine in the brain. These hormones play a role in controlling mood and behavior. Lisdexamfetamine works by blocking the reuptake of dopamine and norepinephrine by neurons. This increases the amount of dopamine and norepinephrine available to cells, which in turn increases attention and lowers impulsivity and hyperactivity.
How Long Does it Take to Work?
The effects of lisdexamfetamine can be felt within an hour, although it may take up to 3 hours to reach its peak effects. The effects usually last up to 14 hours.
Absorption
Lisdexamfetamine is rapidly absorbed. It reaches peak concentrations in the bloodstream 1-2 hours after administration.
Route of Elimination
Lisdexamfetamine is primarily eliminated via the kidneys. A small amount can also be eliminated through the feces.
Dosage
The recommended dose of lisdexamfetamine for adults is 30-70 mg per day. The recommended dose for children 6 to 12 years old is 30-50 mg per day. The dose needs to be adjusted according to response and tolerance. The maximum recommended dose is 70mg per day.
Administration
Lisdexamfetamine should be taken by mouth once daily, preferably in the morning. It can be taken with or without food.
Side Effects
Common side effects of lisdexamfetamine include nausea, headache, dry mouth, insomnia, and decreased appetite. Other side effects include dizziness, irritability, nervousness, restlessness, and increased heart rate.
Toxicity
Lisdexamfetamine can be toxic if taken in large amounts. Symptoms of overdose may include vomiting, diarrhea, confusion, tremors, restlessness, increased heart rate, and agitation. In severe cases, coma, seizures, and death can occur.
Precautions
Lisdexamfetamine should not be taken if you have a history of heart disease, high blood pressure, glaucoma, an overactive thyroid, tics or Tourette’s syndrome. It should also be avoided in people with a history of drug or alcohol abuse.
Interaction
Lisdexamfetamine may interact with certain medications, such as antidepressants, antipsychotics, and anticonvulsants. It can also interact with certain supplements such as omega-3 fatty acids, melatonin, and St. John's wort.
Disease Interactions
People with heart disease, high blood pressure, glaucoma, and an overactive thyroid should avoid taking lisdexamfetamine. People with a history of drug or alcohol abuse should also avoid taking lisdexamfetamine.
Drug Interactions
Lisdexamfetamine may interact with certain medications, such as antidepressants, antipsychotics, anticonvulsants, and supplements such as omega-3 fatty acids, melatonin, and St. John's Wort. It is important to tell your doctor or pharmacist about all the medications, vitamins, and herbs you are taking before taking lisdexamfetamine.
Food Interactions
Taking lisdexamfetamine with food may reduce its effectiveness. Alcohol should not be consumed while taking lisdexamfetamine as it can increase the risk of serious side effects.
Pregnancy Use
Lisdexamfetamine is classed as a category C medication, which means it is not recommended for use during pregnancy due to potential harm to the unborn baby.
Lactation Use
Lisdexamfetamine is not recommended for use while breastfeeding due to the potential risk of serious side effects to the infant.
Acute Overdose
Symptoms of an overdose may include vomiting, diarrhea, confusion, tremors, restlessness, increased heart rate, and agitation. In severe cases, coma, seizures, and death can occur. If you suspect an overdose, contact a poison control center immediately.
Contraindication
Lisdexamfetamine should not be taken by people with a history of drug or alcohol abuse. It should also not be taken by people with heart disease, high blood pressure, glaucoma, an overactive thyroid, or tics or Tourette’s syndrome. People with a history of psychosis or manic episodes should also not take this medication.
Use Direction
Lisdexamfetamine should be taken as instructed by your doctor or pharmacist. It may be taken with or without food. The dose should be adjusted according to response and tolerance. The maximum recommended dose is 70mg per day.
Storage Condition
Lisdexamfetamine should be stored at room temperature away from light and moisture. Keep out of reach of children.
Volume of Distribution
The volume of distribution for lisdexamfetamine is 3.7 L/kg.
Half Life
The half-life of lisdexamfetamine is 10 hours.
Clearance
The clearance of lisdexamfetamine is 152 mL/min/1.73m2.
Here you find in details version of Lisdexamfetamine