Levemir
Levemir Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Levemir is a brand name. Its generic name is Insulin Detemir.
Introduction
Levemir is an insulin analog that is used as a long-acting insulin for adults and children with diabetes mellitus. It has a "tail" attached to it that binds to body tissues and slows the absorption and action of insulin. This helps it to provide more even levels of blood glucose control for up to 24 hours.Uses for
Levemir is used to lower blood glucose in people who have type 1 diabetes (diabetes mellitus) and to help control blood glucose levels in people who have type 2 diabetes. It is usually used together with a short-acting insulin that is taken before meals.Mechanism of Action
Levemir works by stimulating the uptake of glucose into cells, increasing the production of glycogen, and inhibiting the production of glucose by the liver. It also helps to reduce ketoacidosis (high levels of ketones in the blood due to an insufficiency of insulin).How Long Does It Take To Work
Levemir typically begins to work after 30 minutes and can be effective for up to 24 hours.Absorption
Levemir is slowly absorbed by the body, with peak levels typically occurring between 6 and 8 hours after administration.Route of Elimination
Levemir is eliminated from the body by renal excretion and metabolism in the liver.Dosage
Dosage of Levemir is individualized and based on the needs and response of the patient. The usual starting dose for adults with type 1 diabetes is 8–16 U per day. The dosage should be adjusted according to the patient's blood glucose levels, usually every five to 10 days.Administration
Levemir can be taken either subcutaneously by injection or by an insulin pump.Side Effects
Common side effects of Levemir include hypoglycemia (low blood sugar), weight gain, headaches, nausea, and injection site reactions.Toxicity
Levemir is considered to be well tolerated, however high doses may lead to hypoglycemia (low blood sugars).Precautions
Patients taking Levemir should monitor their blood glucose levels regularly and follow instructions for proper injection techniques. Additionally, patients should monitor for side effects such as hypoglycemia, weight gain, or injection site reactions.Interaction
Levemir may interact with certain medications (such as barbiturates, beta-blockers, diuretics, and oral antidiabetics) or alcohol. Therefore it is important to tell your doctor about any medications or supplements you are taking before starting Levemir.Disease Interaction
Levemir should not be used in patients with type 1 diabetes mellitus who are at risk for ketoacidosis, as well as in patients with unstable or severe renal or hepatic impairment.Drug Interaction
Drugs that can interact with Levemir include barbiturates, beta-blockers, diuretics, and oral antidiabetic agents.Food Interactions
Foods that can interact with Levemir include those that are high in sugar, particularly simple sugars such as candy, fruit juices, soda, and baked goods.Pregnancy Use
Levemir is not recommended for use in pregnant women unless clearly needed. Women who are pregnant or planning to become pregnant should discuss the benefits and risks of taking Levemir with their doctor.Lactation Use
Levemir should be used with caution in breastfeeding mothers. Before taking it, women should discuss any potential risks with their doctor.Acute Overdose
Overdose of Levemir can cause hypoglycemia (low blood sugar) and seizures. Treatment of overdose should include the administration of sugar or glucose and close monitoring of the patient’s blood glucose levels.Contraindication
Levemir is contraindicated in patients who have had an allergic reaction to it or any of its ingredients, as well as those with type 1 diabetes mellitus who are at risk for ketoacidosis.Use Direction
Levemir should be taken as prescribed by your doctor. It should not be taken without the supervision of a healthcare provider.Storage Condition
Levemir should be stored in the refrigerator between 2-8°C (36-46°F). It should be protected from light and should not be frozen.Volume of Distribution
The volume of distribution for Levemir is 79.2 L.Half Life
The half life of Levemir is 23.3 hours.Clearance
The clearance of Levemir is 200 mL/min.Here you find in details version of Levemir
Some Frequently Asked Questions About Levemir
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http://www.pharmgkb.org/drug/PA164746470,
http://www.rxlist.com/levemir-drug.htm,
https://www.drugs.com/monograph/insulin-detemir.html,
http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileName=lev1746.html&contentName=Levemir&contentId=435,
https://en.wikipedia.org/wiki/Insulin_detemir,