Ictrol

Ictrol Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Ictrol is a brand name. Its generic name is Lacosamide.

Ictrol Introduction

Ictrol is a novel antiepileptic drug that is used in the treatment of partial onset seizures in adults with epilepsy. It is chemically related to the carbonic anhydrase inhibitor, acetazolamide and thus shares a similar mechanism of action. It has a faster onset of action than traditional antiepileptic drugs and is easily absorbed into systemic circulation.

Uses for Ictrol

Ictrol is indicated for the treatment of partial onset seizures in adults with epilepsy. It has also been found to be effective in the treatment of pain associated with diabetic neuropathy.

Mechanism of Action

Ictrol works by prolonging the voltage-gated sodium channel inactivation, thereby increasing the inactivation of the depolarization-gated sodium channels. This leads to slower membrane depolarization, and thus decreases seizure activity. It also increases the excitability threshold of neurons, thereby further decreasing the seizure activity.

How Long Does It Take to Work?

Ictrol typically works within one to two weeks. It takes about four to eight weeks to get the full benefit of this medication.

Absorption

Ictrol is rapidly and completely absorbed from the gastrointestinal tract, and peak plasma concentrations are reached within one hour. It has an absolute oral bioavailability of approximately 100%.

Route of Elimination

Ictrol is eliminated predominantly via renal excretion, with approximately 80% of the administered dose excreted unchanged in the urine.

Dosage

The recommended starting dose is 100-200mg twice daily. The dose should then be slowly increased to a maximum of 400mg two times a day. Ictrol can be taken with or without food.

Administration

Ictrol should be taken orally either with or without food. It should not be crushed, chewed or split. Swallow the medication whole with a glass of water. Do not alter the dose or stop taking this medication without the guidance of a doctor.

Side Effects

The most common side effects of Ictrol are nausea, dizziness, headache, fatigue, and ataxia. Other potential side effects include tremor, depression, confusion, and rash.

Toxicity

Ictrol has a very low toxicity profile, and there have been no reports of significant toxicity associated with its use. It is contraindicated in patients with known hypersensitivity to the medication.

Precautions

Patients taking lacosamide should inform their doctor of any other medications they are currently taking, as the drug may interact with anticonvulsants, tranquilizers, or sedatives. It may also interact with antacids, antibiotics, blood pressure medications, diuretics, HIV medications, and birth control pills. Do not stop taking lacosamide without consulting with a healthcare provider.

Interactions

Ictrol may interact with other antiepileptic medications such as carbamazepine, phenytoin, lamotrigine, levetiracetam, felbamate, oxcarbazepine, valproic acid, and zonisamide. It may also interact with other medications such as antacids, antibiotics, and birth control pills. Patients should always tell their healthcare provider about all medications they are taking.

Disease Interactions

Ictrol may interact with certain diseases or conditions such as liver or kidney disease, pregnancy, or lactation. Patients should always inform their doctor of any medical history or conditions in order to reduce the risk of drug interaction.

Drug Interactions

Ictrol may interact with other drugs. Patients should inform their doctor of all medications they are taking in order to prevent drug interaction. Drugs that may interact with lacosamide include anticonvulsants, tranquilizers, sedatives, antacids, antibiotics, and blood pressure medications.

Food Interactions

Ictrol should not be taken with grapefruit or grapefruit juice as grapefruit may increase the levels of lacosamide in the body. Avoid alcohol while taking this medication as it may increase the risk of side effects.

Pregnancy Use

Ictrol is classified as pregnancy category C, meaning that it is unknown whether or not it may harm an unborn baby. Patients should always inform their doctor if they are pregnant or planning to become pregnant in order to reduce the risk of harm.

Lactation Use

It is unknown whether or not lacosamide is excreted in human milk. Patients should always inform their doctor if they are breastfeeding in order to minimize the risk of harm.

Acute Overdose

Signs and symptoms of an acute overdose may include confusion, agitation, sedation, nausea, and vomiting. If an overdose is suspected, contact a poison control center or emergency room immediately.

Contraindication

Ictrol is contraindicated in patients with known hypersensitivity to the medication. It should also not be used in patients who have a history of kidney or liver impairment or in those with a known hypersensitivity to carbonic anhydrase inhibitors.

Use Direction

The recommended starting dose of lacosamide is 100mg two times a day. The dose should be slowly increased to a maximum of 400mg two times a day. Ictrol should be taken orally with or without food. It should not be split, chewed, or crushed. Swallow the medication whole with a glass of water.

Storage Condition

Keep lacosamide in a tight, light-resistant container at room temperature. It should be stored away from heat, light, and moisture. Do not freeze this medication.

Volume of Distribution

The volume of distribution of lacosamide is approximately 19L, indicating a very low degree of tissue binding.

Half Life

The half-life of lacosamide is approximately 13 hours. This indicates that the drug has a relatively short half-life, allowing for quick and easy clearance from the body.

Clearance

The clearance of lacosamide is approximately 15 ml/min, making it a highly water-soluble drug.

Here you find in details version of Ictrol

Some Frequently Asked Questions About Ictrol

What is Ictrol?

Ictrol is an anticonvulsant medication used to treat partial-onset seizures in adults with epilepsy.

How does Ictrol work?

Ictrol works by stabilizing electrical activity in the brain. It acts on sodium channels on the membrane of nerve cells in the brain, preventing the spread of seizure activity.

What are the potential side effects of Ictrol?

The most common side effects of lacosamide include dizziness, headache, nausea, vomiting, blurred vision, and fatigue. Other potential, less common side effects include abdominal pain, chest pain, confusion, skin rash, and difficulty sleeping. Talk to your doctor about possible side effects.

Is Ictrol an antidepressant?

No, lacosamide is not an antidepressant. It is an anticonvulsant medication used to treat partial-onset seizures in adults with epilepsy.

Can I take Ictrol while pregnant or breastfeeding?

No, Ictrol should not be used during pregnancy or while breastfeeding. It may be harmful to an unborn baby. Talk to your doctor about the best treatment options if you are pregnant or breastfeeding.

What should I do if I miss a dose of Ictrol?

If you miss a dose of Ictrol, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose of the medication.

What should I avoid while taking Ictrol?

You should avoid drinking alcohol while taking Ictrol, as it may increase the risk of side effects. You should also avoid taking other medications that affect the brain, such as sedatives or antidepressants, without first talking to your doctor.

What is the usual dosage of Ictrol?

The usual starting dose of Ictrol is 200 mg, taken twice daily. Your doctor may increase the dosage up to 400 mg, taken twice daily, based on your response to treatment.

How long does it take for Ictrol to work?

It may take several weeks for Ictrol to reach its full effect. If you are not seeing any improvement in your symptoms after a few weeks of treatment, talk to your doctor.

Is Ictrol habit-forming?

No, lacosamide is not known to be habit-forming. However, it is important to take the medication exactly as prescribed by your doctor.

What should I tell my doctor before taking Ictrol?

Before taking Ictrol, tell your doctor about any other medical conditions you have, any medications you are taking, and any allergies you may have. Be sure to also tell your doctor if you are pregnant or breastfeeding.

Can I take over-the-counter medications while taking Ictrol?

You should talk to your doctor before taking any over-the-counter medications while taking Ictrol, as some medications may interact with the medication and cause harmful effects.

What should I do if I experience a seizure?

If you experience a seizure, stay calm and stay in a safe place until the seizure stops. If the seizure does not stop, call 911 or your local emergency medical services.

What type of seizures does Ictrol treat?

Ictrol is used to treat partial-onset seizures in adults with epilepsy.

Can children take Ictrol?

No, Ictrol is not recommended for use in children. It should only be used in adults with epilepsy.

Will Ictrol affect my thinking and alertness?

Yes, Ictrol may cause changes in thinking and alertness. If this occurs, do not operate a vehicle or machinery until your thinking and alertness returns.

Is weight gain a potential side effect of Ictrol?

Weight gain has been reported as a potential side effect of Ictrol. Talk to your doctor if you experience an increase in appetite or weight gain while taking this medication.

Can I stop taking Ictrol suddenly?

No, you should not stop taking Ictrol suddenly. Doing so may increase your risk of seizures. Talk to your doctor before stopping or decreasing your dose of Ictrol.

Can I take other anticonvulsants while taking Ictrol?

Yes, you can take other anticonvulsants while taking Ictrol. However, it is important to talk to your doctor before starting or stopping any medications.

How long does Ictrol stay in my system?

The half-life of Ictrol is typically between 12 and 14 hours. However, individual metabolism and other factors may affect the drug’s duration in the body.

What form(s) does Ictrol come in?

Ictrol comes in capsule form. It is typically taken two times a day.

Can I take Ictrol with other medications?

You should talk to your doctor before taking any other medications while taking Ictrol, as some medications may interact with the medication and cause harmful effects.

Does Ictrol contain gluten?

No, Ictrol does not contain gluten.

Does Ictrol cause drowsiness?

Yes, drowsiness is a common side effect of Ictrol. It is important to talk to your doctor if you experience drowsiness while taking Ictrol.

What are the common drug interactions of Ictrol?

Common drug interactions of Ictrol include opioids, corticosteroids, anticoagulants, oral contraceptives, and hydantoins. Talk to your doctor or pharmacist about any potential drug interactions.

Does Ictrol cause hair loss?

Hair loss has been reported as a potential side effect of Ictrol. Talk to your doctor if you experience hair loss while taking this medication.

Can Ictrol cause stomach pain?

Stomach pain is a possible side effect of Ictrol. Talk to your doctor if you experience any abdominal pain while taking this medication.

Is Ictrol addictive?

No, Ictrol is not known to be addictive. However, it is important to take the medication exactly as prescribed by your doctor.

Does Ictrol interact with vitamins or supplements?

Yes, lacosamide may interact with certain vitamins or supplements. Talk to your doctor before taking any vitamins or supplements while taking this medication.

Does Ictrol have an expiration date?

Yes, Ictrol does have an expiration date. Check the expiration date before taking any medication.

Can I take Ictrol while breastfeeding?

No, Ictrol should not be used while breastfeeding. It may be harmful to a nursing baby. Talk to your doctor about the best treatment options if you are breastfeeding.

How do I store Ictrol?

Ictrol should be stored at room temperature away from light, heat, and moisture. Keep the medication in a secure place where others cannot access it.

Can Ictrol cause problems with my liver?

Yes, Ictrol can cause problems with the liver. Your doctor may need to test your liver function periodically while taking the medication. Talk to your doctor if you have any concerns.

Is Ictrol safe for long-term use?

Yes, Ictrol is generally safe for long-term use. However, it is important to talk to your doctor before taking any medication for a prolonged period of time.

Who manufactures Ictrol?

Ictrol is manufactured by Daiichi Sankyo, Inc.

How should I take Ictrol?

Take Ictrol exactly as prescribed by your doctor. Do not take more or less of the medication than recommended. Do not take the medication more often than prescribed.

What happens if I overdose on Ictrol?

If you suspect an overdose, seek medical attention immediately. Symptoms of an overdose may include confusion, difficulty breathing, dizziness, and loss of consciousness.

Can I breastfeed while taking Ictrol?

No, Ictrol should not be used while breastfeeding. It may be harmful to a nursing baby. Talk to your doctor about the best treatment options if you are breastfeeding.

Are there any alternative treatments for epilepsy?

Yes, there are other treatments for epilepsy, such as lifestyle modifications (e.g. exercise and stress reduction), dietary changes (e.g. following a ketogenic diet), and vitamins and supplements (e.g. omega-3 fatty acids). Talk to your doctor about the best treatment options for you.

Can I take Ictrol with other anticonvulsants?

Yes, you can take other anticonvulsants while taking Ictrol. However, it is important to talk to your doctor before starting or stopping any medications.

Does Ictrol have withdrawal symptoms?

Yes, withdrawal symptoms may occur if you stop taking Ictrol suddenly. These symptoms may include seizures, dizziness, and fatigue. It is important to talk to your doctor before stopping or decreasing your dose of Ictrol.

Does Ictrol cause depression?

No, Ictrol is not known to cause depression. However, it is important to talk to your doctor if you experience any changes in mood while taking this medication.

Is Ictrol available in generic form?

Yes, Ictrol is available in generic form. It is typically less expensive than brand-name medications.