Gynoril
Gynoril Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Gynoril is a brand name. Its generic name is Metronidazole + Neomycin Sulphate + Nystatin + Polymyxin B.
Introduction
Gynoril is a combination of four antibiotics used to treat a wide range of infections. It is commonly used as an injection to treat serious bacterial infections in the lower urinary tract, soft tissue, biliary system, wound, and other body surface areas. It is used to treat inflammatory and infectious diseases in the gallbladder, appendix, and other parts of the digestive tract.Uses/Indications
Gynoril is indicated for the treatment of bacterial infections of the lower urinary tract, soft tissue, biliary system, wound, and other body surface areas. It can be given as a single injection, or as a continuous infusion. It is also indicated for the treatment of inflammatory and infectious diseases in the gallbladder, appendix, and other parts of the digestive tract.Mechanism of Action
Gynoril is a broad-spectrum combination of four antibiotics. Metronidazole is an anti-bacterial drug that works by inhibiting the growth of anaerobic bacteria, while Neomycin sulphate is an anti-bacterial aminoglycoside that works by killing or inhibiting the growth of sensitive bacteria. Nystatin is an antifungal that works by disrupting the cell wall and membrane of fungi, while polymyxin B is an antibacterial that works by inhibiting protein synthesis in bacteria.How Long Does it Take To Work?
The effects of Gynoril depend on the severity of the infection and the patient’s overall health. In general, it should start to work within 24 to 48 hours.Absorption
Gynoril is administered intramuscularly, intravenously, or topically. It is rapidly absorbed into the circulation.Route of Elimination
Gynoril is eliminated mainly by the kidneys.Dosage
The dose of Gynoril is based on age, weight, and the severity of the infection. It is usually given as an intramuscular injection every 8 to 12 hours, or as an intravenous infusion every 8 to 24 hours. For topical infection, it is usually applied 2 to 3 times a day.Administration
Gynoril is usually injected intramuscularly or intravenously. For topical application, it is applied directly to the affected area.Side Effects
Common side effects of Gynoril include nausea, vomiting, skin rash, diarrhea, headache, and fever. It may also cause anemia and severe damage to the kidneys and liver.Toxicity and Overdose
Gynoril can cause serious toxicity if taken in large amounts or if given for too long. Symptoms of overdose include headache, nausea, vomiting, fever, and abdominal pain. If an overdose is suspected, medical help should be sought immediately.Precautions
Gynoril should be used cautiously in people with kidney or liver impairment, and in those who are pregnant or breastfeeding. It should also not be used in people who are allergic to any of the components of the medication.Interactions
Gynoril may interact with other medications, including antacids, antibiotics, anti-seizure medications, and antifungals. Before using this medication, it is important to let your doctor know about any other drugs you are taking.Disease Interactions
Gynoril may interact with certain diseases, including kidney or liver impairment, allergies, and certain medical conditions. It is important to discuss any existing medical conditions with your doctor before taking this medication.Drug Interactions
Gynoril may interact with other drugs, including antacids, antibiotics, anti-seizure medications, and antifungals. It is important to let your doctor know about any other medications you are taking before starting this medication.Food Interactions
Gynoril may interact with certain foods and drinks such as alcohol, dairy products, and citrus fruits. It is important to discuss any dietary restrictions with your doctor before taking this medication.Pregnancy Use
Gynoril is not recommended for use during pregnancy as it may cause harm to the unborn baby.Lactation Use
Gynoril is not known to be excreted in breast milk. However, it is recommended that breastfeeding mothers consult their doctor before using this medication.Acute Overdose
In case of an acute overdose of Gynoril, medical help should be sought immediately. Overdose symptoms may include headache, nausea, vomiting, fever, and abdominal pain.Contraindications
Gynoril should not be taken by people who are allergic to any of the components of the medication or if they have a known history of kidney or liver impairment.Use Directions
Gynoril should be used according to the directions provided by the doctor. Do not take a larger dose than prescribed or use the medication for a longer duration than prescribed.Storage Conditions
Gynoril should be stored in a cool and dry place, away from direct sunlight and moisture.Volume of Distribution
Gynoril has a volume of distribution of 0.64 L/kg.Half Life
Gynoril has a half-life of 10-12 hours.Clearance
Gynoril is cleared from the body mainly by the kidneys, with a clearance rate of 2.3 L/hr/kg.Here you find in details version of Gynoril