Guaifenesin
Guaifenesin Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Guaifenesin is a brand name. Its generic name is Dextromethorphan + Guaifenesin + Pseudoephedrine.
Introduction
Guaifenesin (also known as DMGPE) is a combination of three medications primarily used to treat various symptoms associated with upper respiratory tract infections such as cough, congestion, and sinus pressure. It works by blocking the action of a certain natural substance in the brain known as a cough reflex center and helps to reduce swelling in the lining of the nose and sinuses, thus relieving congestion and allowing the patient to breathe easier. It also has antitussive (reducing or suppressing coughing) properties, which may help alleviate annoying coughs due to colds.Uses for
DMGPE is mainly used for the relief of various symptoms associated with upper respiratory tract infections such as cough, congestion, and sinus pressure. It may also be used for other conditions as determined by your doctor.Mechanism of Action
Dextromethorphan is a cough suppressant that works by activating a certain natural substance in the brain known as a cough reflex center. Guaifenesin is an expectorant that works by loosening mucus from the lungs and sinuses, thus allowing the patient to cough it up more easily. Pseudoephedrine is a nasal decongestant that works by constricting the blood vessels in the lining of the nose, thus reducing swelling and allowing the patient to breathe more easily.How Long Does It Take to Work?
DMGPE typically takes 30 minutes to take effect and usually lasts for several hours.Absorption
DMGPE is rapidly absorbed in the body and reaches peak concentration in the blood within an hour of ingestion.Route of Elimination
DMGPE is primarily eliminated through the kidneys.Dosage
The recommended adult dose of DMGPE is 15 - 30 ml per dose every 4 - 6 hours as needed for coughs, or as advised by a doctor. Children 6 to 12 years of age: 5-15 ml per dose every 4 - 6 hours, or as advised by a doctor.Administration
DMGPE should be taken orally with a glass of water. It should not be taken with other medications or with any beverage other than plain water. For maximum benefit, do not lie down for 15 minutes after taking this medication. DMGPE should not be used more often or for longer periods of time than directed.Side Effects
Common side effects associated with DMGPE include drowsiness, dizziness, nausea, vomiting, dry mouth, headache, insomnia and nervousness. If these symptoms persist or worsen, contact your doctor immediately.Toxicity
If taken as directed, DMGPE is generally well tolerated. However, overdosing may result in serious side effects including difficulty breathing, irregular heartbeat, elevated blood pressure, chest pain, confusion, hallucinations, extreme restlessness, agitated behavior, and seizures. In cases of overdosing, seek medical help immediately.Precautions
Before taking DMGPE, inform your doctor if you have asthma, diabetes, heart, liver or kidney disease, an over-active thyroid, phenylketonuria (PKU), frequent allergies, or difficulty in urination due to an enlarged prostate. DMGPE may cause dizziness or drowsiness, do not drive or operate heavy machinery until you know how you react to this medication.Interactions
DMGPE may interact with other medications or supplements that you are currently taking, including but not limited to monoamine oxidase inhibitors (MAOIs), certain anti-depressants, anti-anxiety medications, blood thinners, allergy medications, and sleeping medication. It is important to tell your doctor about all medications and supplements you are taking to avoid potential interactions.Disease Interaction
Certain diseases may affect the use of DMGPE. Before taking this medication, inform your doctor if you have asthma, diabetes, heart, liver or kidney disease, an over-active thyroid, phenylketonuria (PKU), frequent allergies, or difficulty in urination due to an enlarged prostate.Drug Interaction
DMGPE may interact with other medications or supplements that you are currently taking, including but not limited to monoamine oxidase inhibitors (MAOIs), certain anti-depressants, anti-anxiety medications, blood thinners, allergy medications, and sleeping medication. It is important to tell your doctor about all medications and supplements you are taking to avoid potential interactions.Food Interactions
No food interactions have been reported with DMGPE.Pregnancy Use
DMGPE is not recommended for use during pregnancy due to the potential risks. It is always best to speak with your doctor before taking any medication during pregnancy.Lactation Use
DMGPE is not recommended for use while breastfeeding due to the potential risks. It is always best to speak with your doctor before taking any medication while breastfeeding.Acute Overdose
In cases of acute overdose, seek medical help immediately. Overdosing may result in serious side effects including difficulty breathing, irregular heartbeat, elevated blood pressure, chest pain, confusion, hallucinations, extreme restlessness, agitated behavior, and seizures.Contraindication
DMGPE should not be used by individuals who are hypersensitive/allergic to any of its components. It should also not be used by individuals with narrow-angle glaucoma, urinary retention, or severe hypertension.Use Direction
Take DMGPE exactly as directed by your doctor. It is typically taken orally with a glass of water. Do not lie down for at least 15 minutes after taking DMGPE. Do not use more often or for longer periods of time than directed.Storage Condition
Store DMGPE at room temperature and keep it away from heat and light. Do not freeze. Keep the medication in a closed container and out of reach of children.Volume of Distribution
The volume of distribution of DMGPE is approximately 1.2 L/kg.Half Life
The half-life of DMGPE is approximately 4-5 hours.Clearance
The clearance of DMGPE is approximately 0.9 ml/min/kg.Here you find in details version of Guaifenesin
Some Frequently Asked Questions About Guaifenesin
not coverdWhat is Guaifenesin?
Guaifenesin is an oral cough and cold combination medication used to temporarily relieve nasal congestion, runny nose, sneezing, and associated cough caused by allergies or the common cold.
Is Guaifenesin safe to use?
When used as directed, Guaifenesin is generally safe and very effective for symptom relief.
Who should not use Guaifenesin?
Individuals with high blood pressure, glaucoma, an enlarged thyroid,thyroiditis, diabetes, heart disease, difficulty in urination due to an enlarged prostate gland, or those taking certain antidepressants should not use this product without first consulting a doctor. Women who are pregnant or nursing should consult their doctor prior to use.
What are the side effects of Guaifenesin?
Common side effects of Guaifenesin include drowsiness, dizziness, headache, and difficulty sleeping. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Does Guaifenesin interact with other medications?
Guaifenesin may interact with certain antibiotics, antidepressants, heart medication, seizure medication, or MAO inhibitors. To avoid potential interactions, be sure to tell your doctor about any other medications you may be taking.
Can children take Guaifenesin?
Guaifenesin is approved for use in children ages 12 years and older. Children under the age of 12 should not take this medication without consulting a doctor.
What is the recommended dosage of Guaifenesin?
The recommended dosage of Guaifenesin is 1 capsule every 12 hours. Do not exceed two capsules in 24 hours.
Are there different forms of Guaifenesin available?
Guaifenesin is available in capsule, tablet, or liquid form.
What happens if I miss a dose of Guaifenesin?
If you miss a dose of Guaifenesin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Should I avoid any activities while taking Guaifenesin?
If you experience drowsiness or dizziness while taking Guaifenesin, avoid activities that require mental alertness, such as operating machinery or driving a vehicle.
What are the storage conditions of Guaifenesin?
Store Guaifenesin at room temperature, away from excessive heat, light, and moisture.
How long can I take Guaifenesin for?
Guaifenesin should only be taken for a short period of time, as it is not intended for long-term use. Do not take this medication for longer than recommended by your doctor.
Can I take Guaifenesin if I am pregnant?
Women who are pregnant or nursing should consult their doctor prior to taking Guaifenesin.
Can I take Guaifenesin while breastfeeding?
Women who are breastfeeding should consult their doctor prior to taking Guaifenesin.
What symptoms does Guaifenesin relieve?
Guaifenesin is used to relieve nasal and sinus congestion, runny nose, sneezing, and cough associated with allergies, colds, and the flu.
What are the inactive ingredients in Guaifenesin?
The inactive ingredients for Guaifenesin vary based on the form of the medication. Please consult the product label for a full list of inactive ingredients.
Can I take other forms of medication while taking Guaifenesin?
It is best to avoid taking other forms of medication (prescription or non-prescription) while taking Guaifenesin as there is a risk of potential interactions. If you must take another form of medication, talk to your doctor first.
Can I take Guaifenesin if I have a cold or flu?
Yes, Guaifenesin can be used to relieve symptoms of cold or flu. However, if your symptoms do not improve after 7 days or if they become worse, contact your doctor.
Does Guaifenesin contain alcohol?
No, Guaifenesin does not contain alcohol.
Is Guaifenesin a narcotic?
No, Guaifenesin is not a narcotic.
How long does it take for Guaifenesin to start working?
Guaifenesin typically begins to work within 30 minutes after taking the medication. The maximum effect will usually occur within two hours.
Can I take Guaifenesin with food?
Yes, you can take Guaifenesin with food. However, taking the medication with a meal may reduce some of the side effects, such as stomach upset or nausea.
Can I take an increased dose of Guaifenesin to increase the effectiveness?
No, do not take a higher dose of Guaifenesin than is recommended. Taking a higher dose may result in an increased risk of side effects or potential toxicity.
Does Guaifenesin cause constipation?
Yes, Guaifenesin may cause constipation. It is important to drink plenty of water and exercise regularly while taking this medication.
Can Guaifenesin cause drowsiness?
Yes, Guaifenesin may cause drowsiness or dizziness. If you experience these side effects, it is important to avoid activities that require mental alertness, such as operating machinery or driving a vehicle.
Does Guaifenesin raise blood pressure?
Yes, Guaifenesin may cause an increase in blood pressure. Individuals with high blood pressure, heart disease, glaucoma, an enlarged thyroid, or diabetes should not use this medication without first consulting a doctor.
Will I become addicted to Guaifenesin if I take it for an extended period of time?
No, Guaifenesin is not addictive. However, it should not be taken for an extended period of time, as it is not intended for long-term use.
Does Guaifenesin have any effect on heart rate?
Yes, Guaifenesin may cause an increase in heart rate. If you experience any abnormal heart rate, contact your doctor immediately.
Can I drink alcohol while taking Guaifenesin?
It is best to avoid drinking alcohol while taking Guaifenesin as they can have an additive effect, resulting in increased side effects.
Can I take Guaifenesin if I have asthma?
Individuals with asthma should consult their doctor prior to taking Guaifenesin, as it can worsen breathing symptoms.
Can Guaifenesin be used for long-term use?
No, Guaifenesin is not intended for long-term use. If your symptoms do not improve after 7 days or if they become worse, contact your doctor.
Should I use Guaifenesin if I have a fever?
No, Guaifenesin should not be used to treat a fever. If you have a fever, seek medical attention immediately.
What is the difference between Guaifenesin and Dextromethorphan + Guaifenesin?
Guaifenesin contains an additional ingredient, pseudoephedrine hydrochloride, which helps to reduce inflammation and congestion associated with cold and flu symptoms. Dextromethorphan + Guaifenesin does not contain pseudoephedrine and is not as effective at relieving congestion and inflammation.
Can Guaifenesin be used to treat sinus infections?
No, Guaifenesin cannot be used to treat sinus infections. For sinus infections, seek medical attention immediately.