Glutamic Acid
Glutamic Acid Uses, Dosage, Side Effects, Mechanism of Action, How Long Does it Take to Work? Glutamic Acid is a brand name. Its generic name is Glutamic acid.
Glutamic Acid Introduction
Glutamic Acid (or Glutamate) is an amino acid, an organic compound composed of nitrogen, carbon, hydrogen, and oxygen. Glutamic Acid is the most plentiful amino acid in the human body and is an important part of the cellular metabolism. It is critical for the transport and storage of energies and helps with the control of hormones and enzymes.
Uses of Glutamic Acid
Glutamic Acid has a variety of uses as a food additive, dietary supplement, as a brain fuel and medication. Primarily, it helps to synthesize proteins, for pharmaceutical use and also as a flavor enhancer in food and drinks. Because of its important role in neurochemical processes, glutamic acid may be helpful in treating neurodegenerative disorders like Parkinson’s and Alzheimer’s disease.
Mechanism Of Action
Glutamic Acid plays a major role in the transmission of impulses across nerve cells, helping the brain and other tissues to communicate properly. This process involves the release of the active form, glutamate, and its re-uptake into the neuron from which it was released. Glutamate then binds to receptors on the post-synaptic neuron, which results in the firing of an action potential. Once the action potential is received, the re-uptake of glutamate resumes to help ensure a proper functioning of the nerve cell.
How Long Does It Take To Work?
The effects of glutamic acid depend on the particular application. When applied as a food additive, it is almost immediate. When used as a drug or dietary supplement, it can take several days or longer to experience the desired effect.
Absorption
Glutamic Acid is Well absorbed from the gastrointestinal system and reaches peak concentrations in the blood quickly.
Route Of Elimination
Glutamic Acid is rapidly eliminated, mainly through the kidneys. However, some of it is metabolized in the liver and excreted through the feces.
Dosage
The recommended daily dosage of glutamic acid depends on age, gender, and the particular purpose for which it is being taken. It is important to consult with a doctor or pharmacist to get the appropriate dosage of glutamic acid for each individual.
Administration
Glutamic Acid may be administered orally in the form of tablets or capsules. Depending on the purpose of use, it can also be applied topically, taken as an intravenous or intramuscular injection, or inhaled.
Side Effect
Side effects of glutamic acid are usually mild and may include nausea, abdominal pain, and headaches. It can also cause bloating, belching, and diarrhea in some people. Rarely, glutamic acid may also cause seizures.
Toxicity
Glutamic Acid is generally well-tolerated and does not have any known long-term toxic effects. However, in high doses, it may cause overstimulation of the nervous system, leading to seizures and other adverse reactions.
Precaution
Patients with liver or kidney disorders should consult with a doctor before taking glutamic acid. Children, pregnant women, and nursing mothers should not take glutamic acid without prior medical advice.
Interaction
Glutamic Acid may interact with certain medications and other supplements, such as anticonvulsants and prescription antidepressants. Therefore, it is important to consult with a doctor before taking glutamic acid, especially if already taking any kind of medication.
Disease Interaction
Glutamic Acid may have beneficial effects in people suffering from specific diseases, such as epilepsy, depression, and some neurodegenerative conditions. It is especially helpful in reducing the frequency of seizures in epilepsy. However, it is important to consult with a healthcare professional before taking glutamic acid for any medical condition.
Drug Interaction
Some medications may interact with glutamic acid. These include anticonvulsants, prescription antidepressants, and certain antibiotics. It is important to consult with a doctor or pharmacist before taking any new medications in combination with glutamic acid.
Food Interactions
Glutamic Acid is found naturally in some foods, including meats, dairy products, vegetables, and grains. It may interact with certain other foods, and it is important to make sure to consume it in moderation for maximum effectiveness.
Pregnancy Use
Glutamic Acid is not recommended for use by pregnant women. It may interfere with normal fetal development and should be avoided.
Lactation Use
Glutamic Acid is not recommended for use by nursing mothers. It may interfere with the production and excretion of breast milk and should be avoided.
Acute Overdose
An acute overdose of glutamic acid is unlikely, as it is rapidly eliminated from the body. However, if large amounts are ingested, it can lead to neurological symptoms such as confusion, tremors, and seizures.
Contraindication
Glutamic Acid should not be used in individuals with known allergies to the compound, and should also be avoided in patients with liver or kidney disorders, or in pregnant or nursing women.
Use Direction
Glutamic Acid should be taken as directed by a doctor or pharmacist. It should not be taken in larger or smaller amounts than recommended, or for longer or shorter than advised.
Storage Condition
Glutamic Acid should be stored in a tightly sealed container, away from heat, moisture, and direct sunlight. It should be kept out of the reach of children and pets.
Volume Of Distribution
Glutamic Acid has a volume of distribution of approximately 10.5 L/kg, indicating that it is widely distributed throughout the body.
Half Life
The half life of glutamic acid is around 1.6 hours, indicating that it needs to be taken 2-3 times a day to maintain therapeutic levels in the body.
Clearance
Glutamic Acid is rapidly cleared from the body, mainly through the kidneys. Approximately two thirds of the drug are metabolized in the liver and excreted in the feces.
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